ABCCE_DICDI
ID ABCCE_DICDI Reviewed; 1317 AA.
AC Q54K24;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=ABC transporter C family member 14;
DE AltName: Full=ABC transporter ABCC.14;
GN Name=abcC14; ORFNames=DDB_G0287589;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family.
CC Conjugate transporter (TC 3.A.1.208) subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000103; EAL63603.1; -; Genomic_DNA.
DR RefSeq; XP_637140.1; XM_632048.1.
DR AlphaFoldDB; Q54K24; -.
DR SMR; Q54K24; -.
DR STRING; 44689.DDB0219976; -.
DR PaxDb; Q54K24; -.
DR EnsemblProtists; EAL63603; EAL63603; DDB_G0287589.
DR GeneID; 8626235; -.
DR KEGG; ddi:DDB_G0287589; -.
DR dictyBase; DDB_G0287589; abcC14.
DR eggNOG; KOG0054; Eukaryota.
DR HOGENOM; CLU_000604_27_1_1; -.
DR InParanoid; Q54K24; -.
DR OMA; VAACAWY; -.
DR PhylomeDB; Q54K24; -.
DR PRO; PR:Q54K24; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd18579; ABC_6TM_ABCC_D1; 1.
DR CDD; cd18580; ABC_6TM_ABCC_D2; 1.
DR Gene3D; 1.20.1560.10; -; 2.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR044746; ABCC_6TM_D1.
DR InterPro; IPR044726; ABCC_6TM_D2.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF90123; SSF90123; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1317
FT /note="ABC transporter C family member 14"
FT /id="PRO_0000363858"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 734..754
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 778..798
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 871..891
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 969..989
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 992..1012
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 119..404
FT /note="ABC transmembrane type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 490..710
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 744..1027
FT /note="ABC transmembrane type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 1071..1306
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 426..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 522..529
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 1105..1112
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1317 AA; 150215 MW; 03E7EE3DE8A3C995 CRC64;
MFINSFETKI KKKFSLLYEK LDDEDENEPS SSPSNSTNNF YKACPEDNSS KWSKISFNWV
TKLIMKGYFK ESLEMNDIYD LPELNKVQTT SKLLDDINFS NGSKYALIKH IYKNFLPKNK
YALISNIFIT IFIFLSPICL KFLINYISTD NDNEKSILKG ILLCCLLCIS ILGQSISQEL
FYWFGMKNSF DVRGALTAKI FEKTLKLSNV SKKKYRSGKI MNIMSIDVEN ISEFFWTYYL
DIVSHTLQIL ILLGLLCYVV GPSGLVGFGV MVIALPINTM LCTKSSNYLE KSLEYSDSRT
NLTSELITNI RPFKMYAWEN LFINKIEEQR KQELKFLFLR VLFWIFDHMM IETNATLVLV
STFATYSLTG NTMSLDVTFT AMTIFANLKL PLIYLPEDIY KAIGLMPSVK RIQNFLKSSE
SLKSKENNQN INFNNNNNNN NNNKNNNNND DNDIIIENCT FQWNEPENNN LFEFNQSEDE
EENEEEEEEE NEENIKINEN FDYKLNDINL IVPKGKLTMI CGVVGSGKTS LVCGLIGEIY
KLNGSVSGVP NNISFTSQQP FLLSASLREN ILFGNEFDIE RYKKVIESTA LTKDIVNLAG
LDLTEIGERG INLSGGQKQR ISLARALYAN SDCFIFDEPL SAVDPEVASH LFDHCIQGID
FKSILKTKEI KKNVENETDS EELIKNEIEI ENEIIDVNNV ISDKNDPNLI EKAKLLVKED
KNEGEVEFNV YKKYFSYGTS GVTLFITISL FFIGQAVYKV SDFWLAIWTE RSIEGKSDSF
YIGYYLLIIG IFVSLLMIRT YSLSRITFGI GKNLHSALLK SVTYASCRFF DTNPSGRILN
RFSKDTSDID IHMLDLLSEV SICFSELTIG LISIVFIIPI IIIPLTLLFI IYYIYQRLYR
PSARELNRWE SITLSPVFSL LQECYNGLLT IRTYKQESRF IKEMFDNINI NLGCIFYSFA
VHRWISMRLE VMGCIMVFFT SLAAALFTSN NGLAALSVTT ALSLNGYLSW GVRRIVELEV
KMNSFQRIQS YIEIPKEGNK LISTGTNQVD SDGLKTISNG DLVNWPNKGI IEFKNVEIKY
RPNSEPNLKD LSFKVQSSEK IGIVGRTGAG KTTIASSLFR MVECSKGLIL IDGIDISKVQ
LQKLRSSIGI VPQDPFIFTG TIRSNIDPFN EFTDFEIWES IEKVKLKDAI NSMPLKLETA
LQENGDNGFS YGQKQLLCLC RTILKNFKII LMDEATSSID YHTAQLIKQT IQENFKDCTT
LTIAHRLETI IDCNKIAVID SGQLIEFDTP SNLMNIPNSK FNKLIKSQTD YSNNKIK
