ID   BCAR3_XENLA             Reviewed;         806 AA.
AC   Q6INP9;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Breast cancer anti-estrogen resistance protein 3 homolog;
GN   Name=bcar3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as an adapter protein. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC072225; AAH72225.1; -; mRNA.
DR   RefSeq; NP_001085199.1; NM_001091730.1.
DR   AlphaFoldDB; Q6INP9; -.
DR   SMR; Q6INP9; -.
DR   PRIDE; Q6INP9; -.
DR   DNASU; 432292; -.
DR   GeneID; 432292; -.
DR   KEGG; xla:432292; -.
DR   CTD; 432292; -.
DR   Xenbase; XB-GENE-6076103; bcar3.L.
DR   OrthoDB; 138275at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 432292; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd10337; SH2_BCAR3; 1.
DR   Gene3D; 1.10.840.10; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR028849; BCAR3.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR   PANTHER; PTHR14247:SF10; PTHR14247:SF10; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00017; SH2; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   2: Evidence at transcript level;
KW   Guanine-nucleotide releasing factor; Reference proteome; SH2 domain.
FT   CHAIN           1..806
FT                   /note="Breast cancer anti-estrogen resistance protein 3
FT                   homolog"
FT                   /id="PRO_0000230287"
FT   DOMAIN          152..251
FT                   /note="SH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT   DOMAIN          538..805
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00168"
FT   REGION          308..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          390..412
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   806 AA;  92238 MW;  45060D4A7E8DF30C CRC64;
     MAAGKFASYH RNVQMNHPLV SSMDLLGSKS ALGERRSDAF KNVCIHGTLP RKKKERVPIR
     SSDMFCHMGT LPHTKSHRLP NPLMQDIKED YPFQERRTGI FNMREHYLDP AMEYVKFSKD
     RYIMDGGTPD KLKKELEEEL KLNSEDLRSH AWYHGRIPRQ VSESLVKRDG DFLIRDSLSS
     PGNLVLTCQW KNLSQHFKIN KVVIRLNEAY CRIQYQLEHE SFDSIPALVR FYVGNRKAVS
     QQSGAIIFQP INRTVPLRCI EEKYGTSPVR RLELGIMEVK SEPTKRLSLN FGQGISQEQS
     LVRGNLLRNK EKSGSQPACL DNMREKRRPL KAHQSESYLP LGSRQPCLSQ GMDMKTSPKP
     HVFRTGSEPT LSPTEIRRFN HEVHPVEALR GSDSQLCPRP PPKPTKAPSI KQSQSPLVWQ
     SSEANYCEFH PTPPEDCAWS DSHSSHNSYI EDQRTDEIET LSFSNSELSF PALDDSISQC
     SATDFCGNVE DDEFIRPVYE TVSSFCPNDF QSVLLTAENK PLETSLLRRA KELFTNNDPR
     TIAKHILRMD CKVARILDVT PEVERMMGVS SGLELIILPY GHQLRLDLME RHSTMAIGIA
     VDILGCTGNL EERVATLHKI IQLAVEVKTL GDYFAFSAIM KALDMPQITR LEQTWTMLRH
     QYTQTAITYE KQLKPFSKYL HEGEALDAQE DVTVPLVMPL VTLLERQSVL FEGMDFWENN
     DRGCEILFNH LQTARQVAHN ATVYKKNAQR ILEGFKPDEL MSEIFKTEFQ MRLLWGSKGA
     LLKQSERYHK FGQILTALSR KLEPPS