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BCCIP_BOVIN
ID   BCCIP_BOVIN             Reviewed;         306 AA.
AC   Q2NL37; Q1JPI1;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=BRCA2 and CDKN1A-interacting protein;
GN   Name=BCCIP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-306.
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: During interphase, required for microtubule organizing and
CC       anchoring activities. During mitosis, required for the organization and
CC       stabilization of the spindle pole. May promote cell cycle arrest by
CC       enhancing the inhibition of CDK2 activity by CDKN1A. May be required
CC       for repair of DNA damage by homologous recombination in conjunction
CC       with BRCA2. May not be involved in non-homologous end joining (NHEJ).
CC       {ECO:0000250|UniProtKB:Q9P287}.
CC   -!- SUBUNIT: Interacts with BRCA2, CDKN1A and MTDH/LYRIC. Interacts with
CC       DCTN1/p150-glued and ACTR1A/ARP1. Interacts with alpha-, beta- and
CC       gamma-tubulins. Interacts with TENT5C; the interaction has no effect on
CC       TENT5C poly(A) polymerase function (By similarity).
CC       {ECO:0000250|UniProtKB:Q9P287}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9P287}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC       centriole {ECO:0000250|UniProtKB:Q9P287}. Cytoplasm, cytoskeleton,
CC       spindle pole {ECO:0000250|UniProtKB:Q9P287}. Note=Colocalizes with
CC       BRCA2 in discrete nuclear foci. In interphase, preferential localizes
CC       to the mother centriole. Recruited to the spindle pole matrix and
CC       centrosome by microtubules and dynein/dynactin activity.
CC       {ECO:0000250|UniProtKB:Q9P287}.
CC   -!- SIMILARITY: Belongs to the BCP1 family. {ECO:0000305}.
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DR   EMBL; BC111124; AAI11125.1; -; mRNA.
DR   EMBL; BT025372; ABF57328.1; -; mRNA.
DR   RefSeq; NP_001039587.1; NM_001046122.2.
DR   AlphaFoldDB; Q2NL37; -.
DR   SMR; Q2NL37; -.
DR   STRING; 9913.ENSBTAP00000007617; -.
DR   PaxDb; Q2NL37; -.
DR   PRIDE; Q2NL37; -.
DR   GeneID; 512466; -.
DR   KEGG; bta:512466; -.
DR   CTD; 56647; -.
DR   eggNOG; KOG3034; Eukaryota.
DR   HOGENOM; CLU_068770_1_1_1; -.
DR   InParanoid; Q2NL37; -.
DR   OrthoDB; 1120393at2759; -.
DR   TreeFam; TF320301; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0097431; C:mitotic spindle pole; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0034453; P:microtubule anchoring; ISS:UniProtKB.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; ISS:UniProtKB.
DR   GO; GO:0090307; P:mitotic spindle assembly; ISS:UniProtKB.
DR   GO; GO:0007052; P:mitotic spindle organization; ISS:UniProtKB.
DR   InterPro; IPR025602; BCP1_family.
DR   PANTHER; PTHR13261; PTHR13261; 1.
DR   Pfam; PF13862; BCCIP; 1.
DR   PIRSF; PIRSF028983; BCP1; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cytoplasm; Cytoskeleton; DNA damage; DNA repair; Nucleus;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..306
FT                   /note="BRCA2 and CDKN1A-interacting protein"
FT                   /id="PRO_0000249686"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          51..159
FT                   /note="Interaction with BRCA2"
FT                   /evidence="ECO:0000250"
FT   REGION          153..251
FT                   /note="Interaction with CDKN1A"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        18..45
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         34
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P287"
FT   MOD_RES         104
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P287"
FT   MOD_RES         273
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CWI3"
SQ   SEQUENCE   306 AA;  35184 MW;  CD72BE59CDDAD177 CRC64;
     MASRPKRRAV SRVPPALGDE EEEDEVEEQD EDDSDEEEDE EDEVVNEEVN IEFEAYSISD
     NDYDGIKKLL QQLFLKAPVN TAELTNLLIQ QNHIGSVIKQ TDVSEDSDDE VDEDEIFGFI
     SLLNLTERKG TPCAEQIKEL ILRLCEKNCE KSMVEQLDRL FNDTARPVGF LLSERFINVP
     PQIALPMHQQ LQKELAEAHR ANKPCGKCYF YLLISKTFVE AGKSNSKKKR SNQKKDELMF
     ANAEEEFFYE KAILKFNYSV QEESDTCLGG RWSFDDVPMK PLRTVMLIPG DKMSEIMEKL
     KEHLSV
 
 
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