BCCIP_BOVIN
ID BCCIP_BOVIN Reviewed; 306 AA.
AC Q2NL37; Q1JPI1;
DT 19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-FEB-2006, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=BRCA2 and CDKN1A-interacting protein;
GN Name=BCCIP;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-306.
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
CC -!- FUNCTION: During interphase, required for microtubule organizing and
CC anchoring activities. During mitosis, required for the organization and
CC stabilization of the spindle pole. May promote cell cycle arrest by
CC enhancing the inhibition of CDK2 activity by CDKN1A. May be required
CC for repair of DNA damage by homologous recombination in conjunction
CC with BRCA2. May not be involved in non-homologous end joining (NHEJ).
CC {ECO:0000250|UniProtKB:Q9P287}.
CC -!- SUBUNIT: Interacts with BRCA2, CDKN1A and MTDH/LYRIC. Interacts with
CC DCTN1/p150-glued and ACTR1A/ARP1. Interacts with alpha-, beta- and
CC gamma-tubulins. Interacts with TENT5C; the interaction has no effect on
CC TENT5C poly(A) polymerase function (By similarity).
CC {ECO:0000250|UniProtKB:Q9P287}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9P287}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC centriole {ECO:0000250|UniProtKB:Q9P287}. Cytoplasm, cytoskeleton,
CC spindle pole {ECO:0000250|UniProtKB:Q9P287}. Note=Colocalizes with
CC BRCA2 in discrete nuclear foci. In interphase, preferential localizes
CC to the mother centriole. Recruited to the spindle pole matrix and
CC centrosome by microtubules and dynein/dynactin activity.
CC {ECO:0000250|UniProtKB:Q9P287}.
CC -!- SIMILARITY: Belongs to the BCP1 family. {ECO:0000305}.
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DR EMBL; BC111124; AAI11125.1; -; mRNA.
DR EMBL; BT025372; ABF57328.1; -; mRNA.
DR RefSeq; NP_001039587.1; NM_001046122.2.
DR AlphaFoldDB; Q2NL37; -.
DR SMR; Q2NL37; -.
DR STRING; 9913.ENSBTAP00000007617; -.
DR PaxDb; Q2NL37; -.
DR PRIDE; Q2NL37; -.
DR GeneID; 512466; -.
DR KEGG; bta:512466; -.
DR CTD; 56647; -.
DR eggNOG; KOG3034; Eukaryota.
DR HOGENOM; CLU_068770_1_1_1; -.
DR InParanoid; Q2NL37; -.
DR OrthoDB; 1120393at2759; -.
DR TreeFam; TF320301; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0097431; C:mitotic spindle pole; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0034453; P:microtubule anchoring; ISS:UniProtKB.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; ISS:UniProtKB.
DR GO; GO:0090307; P:mitotic spindle assembly; ISS:UniProtKB.
DR GO; GO:0007052; P:mitotic spindle organization; ISS:UniProtKB.
DR InterPro; IPR025602; BCP1_family.
DR PANTHER; PTHR13261; PTHR13261; 1.
DR Pfam; PF13862; BCCIP; 1.
DR PIRSF; PIRSF028983; BCP1; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cytoplasm; Cytoskeleton; DNA damage; DNA repair; Nucleus;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..306
FT /note="BRCA2 and CDKN1A-interacting protein"
FT /id="PRO_0000249686"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..159
FT /note="Interaction with BRCA2"
FT /evidence="ECO:0000250"
FT REGION 153..251
FT /note="Interaction with CDKN1A"
FT /evidence="ECO:0000250"
FT COMPBIAS 18..45
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 34
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9P287"
FT MOD_RES 104
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9P287"
FT MOD_RES 273
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9CWI3"
SQ SEQUENCE 306 AA; 35184 MW; CD72BE59CDDAD177 CRC64;
MASRPKRRAV SRVPPALGDE EEEDEVEEQD EDDSDEEEDE EDEVVNEEVN IEFEAYSISD
NDYDGIKKLL QQLFLKAPVN TAELTNLLIQ QNHIGSVIKQ TDVSEDSDDE VDEDEIFGFI
SLLNLTERKG TPCAEQIKEL ILRLCEKNCE KSMVEQLDRL FNDTARPVGF LLSERFINVP
PQIALPMHQQ LQKELAEAHR ANKPCGKCYF YLLISKTFVE AGKSNSKKKR SNQKKDELMF
ANAEEEFFYE KAILKFNYSV QEESDTCLGG RWSFDDVPMK PLRTVMLIPG DKMSEIMEKL
KEHLSV