BCCIP_XENLA
ID BCCIP_XENLA Reviewed; 308 AA.
AC Q6GNI0;
DT 19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 51.
DE RecName: Full=Protein BCCIP homolog;
GN Name=bccip;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: During interphase, required for microtubule organizing and
CC anchoring activities. During mitosis, required for the organization and
CC stabilization of the spindle pole. May promote cell cycle arrest and
CC DNA repair. {ECO:0000250|UniProtKB:Q9P287}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9P287}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC centriole {ECO:0000250|UniProtKB:Q9P287}. Cytoplasm, cytoskeleton,
CC spindle pole {ECO:0000250|UniProtKB:Q9P287}.
CC -!- SIMILARITY: Belongs to the BCP1 family. {ECO:0000305}.
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DR EMBL; BC073531; AAH73531.1; -; mRNA.
DR RefSeq; NP_001085917.1; NM_001092448.1.
DR AlphaFoldDB; Q6GNI0; -.
DR SMR; Q6GNI0; -.
DR DNASU; 444344; -.
DR GeneID; 444344; -.
DR KEGG; xla:444344; -.
DR CTD; 444344; -.
DR Xenbase; XB-GENE-866129; bccip.L.
DR OMA; DFEAYTI; -.
DR OrthoDB; 1120393at2759; -.
DR Proteomes; UP000186698; Chromosome 7L.
DR Bgee; 444344; Expressed in pancreas and 19 other tissues.
DR GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0097431; C:mitotic spindle pole; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0034453; P:microtubule anchoring; ISS:UniProtKB.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; ISS:UniProtKB.
DR GO; GO:0090307; P:mitotic spindle assembly; ISS:UniProtKB.
DR GO; GO:0007052; P:mitotic spindle organization; ISS:UniProtKB.
DR InterPro; IPR025602; BCP1_family.
DR PANTHER; PTHR13261; PTHR13261; 1.
DR Pfam; PF13862; BCCIP; 1.
DR PIRSF; PIRSF028983; BCP1; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cytoplasm; Cytoskeleton; DNA damage; DNA repair; Nucleus;
KW Reference proteome.
FT CHAIN 1..308
FT /note="Protein BCCIP homolog"
FT /id="PRO_0000249690"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..53
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 308 AA; 35172 MW; CACC0B559487E3D9 CRC64;
MASNAKRRAL EPERLLEKHK EDEEDMEGDE SEESDDIEED ESEEDEEVNE EVNIDFEAYT
ISDADYDGIK KLLKQLFLKA HVNISELTDL LIQQNHIGSA IKQAEGQDDS DDDEDDDHVF
GVISLVNLTE RKGTACVEQI KELILSRCEE NCEQSLVEQF DKVLNDNSKP VGFLLSERFI
NVPAQIALPM HQQLQKELAD SQRTNKPCGK CHYYLILSKT FMEATKTSKG SVGSQAKEEL
MFANAEDEFF YEKALVKFNY SVQEESDTQL GGRWSFSDVP MKPLRTAMLV PAERMNSIMD
KFKEYLSV