BCCP_CHLPN
ID BCCP_CHLPN Reviewed; 167 AA.
AC Q9Z901;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=Biotin carboxyl carrier protein of acetyl-CoA carboxylase;
DE Short=BCCP;
GN Name=accB; OrderedLocusNames=CPn_0183, CP_0585, CpB0186;
OS Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=83558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is a component of the acetyl coenzyme A
CC carboxylase complex; first, biotin carboxylase catalyzes the
CC carboxylation of the carrier protein and then the transcarboxylase
CC transfers the carboxyl group to form malonyl-CoA. {ECO:0000250}.
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
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DR EMBL; AE001363; AAD18336.1; -; Genomic_DNA.
DR EMBL; AE002161; AAF38403.1; -; Genomic_DNA.
DR EMBL; BA000008; BAA98393.1; -; Genomic_DNA.
DR EMBL; AE009440; AAP98119.1; -; Genomic_DNA.
DR PIR; F72110; F72110.
DR PIR; G86513; G86513.
DR RefSeq; NP_224392.1; NC_000922.1.
DR RefSeq; WP_010882834.1; NZ_LN847257.1.
DR AlphaFoldDB; Q9Z901; -.
DR SMR; Q9Z901; -.
DR STRING; 115711.CP_0585; -.
DR EnsemblBacteria; AAD18336; AAD18336; CPn_0183.
DR EnsemblBacteria; AAF38403; AAF38403; CP_0585.
DR GeneID; 45050229; -.
DR KEGG; cpa:CP_0585; -.
DR KEGG; cpj:accB; -.
DR KEGG; cpn:CPn_0183; -.
DR KEGG; cpt:CpB0186; -.
DR PATRIC; fig|115713.3.peg.208; -.
DR eggNOG; COG0511; Bacteria.
DR HOGENOM; CLU_016733_3_0_0; -.
DR OrthoDB; 1938042at2; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000000583; Chromosome.
DR Proteomes; UP000000801; Chromosome.
DR GO; GO:0009317; C:acetyl-CoA carboxylase complex; IEA:InterPro.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR001249; AcCoA_biotinCC.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR011053; Single_hybrid_motif.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR PRINTS; PR01071; ACOABIOTINCC.
DR SUPFAM; SSF51230; SSF51230; 1.
DR TIGRFAMs; TIGR00531; BCCP; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
PE 3: Inferred from homology;
KW Biotin; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis;
KW Lipid metabolism.
FT CHAIN 1..167
FT /note="Biotin carboxyl carrier protein of acetyl-CoA
FT carboxylase"
FT /id="PRO_0000146803"
FT DOMAIN 87..163
FT /note="Biotinyl-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01066"
FT REGION 53..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 129
FT /note="N6-biotinyllysine"
FT /evidence="ECO:0000250, ECO:0000255|PROSITE-
FT ProRule:PRU01066"
SQ SEQUENCE 167 AA; 18461 MW; AAA1CF1801F9CE4C CRC64;
MDLKQIEKLM IAMGRNGMKR FAIKREGLEL ELERDTREGN RQEPVFYDSR LFSGFSQERP
IPTDPKKDTI KETTTENSET STTTSSGDFI SSPLVGTFYG SPAPDSPSFV KPGDIVSEDT
IVCIVEAMKV MNEVKAGMSG RVLEVLITNG DPVQFGSKLF RIAKDAS
