BCCP_NOSS1
ID BCCP_NOSS1 Reviewed; 182 AA.
AC Q06881;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Biotin carboxyl carrier protein of acetyl-CoA carboxylase;
DE Short=BCCP;
GN Name=accB; OrderedLocusNames=all5057;
OS Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX NCBI_TaxID=103690;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-10.
RX PubMed=8102363; DOI=10.1128/jb.175.16.5268-5272.1993;
RA Gornicki P., Scappino L.A., Haselkorn R.;
RT "Genes for two subunits of acetyl coenzyme A carboxylase of Anabaena sp.
RT strain PCC 7120: biotin carboxylase and biotin carboxyl carrier protein.";
RL J. Bacteriol. 175:5268-5272(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT "Complete genomic sequence of the filamentous nitrogen-fixing
RT cyanobacterium Anabaena sp. strain PCC 7120.";
RL DNA Res. 8:205-213(2001).
CC -!- FUNCTION: This protein is a component of the acetyl coenzyme A
CC carboxylase complex; first, biotin carboxylase catalyzes the
CC carboxylation of the carrier protein and then the transcarboxylase
CC transfers the carboxyl group to form malonyl-CoA.
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC -!- SUBUNIT: Homodimer.
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DR EMBL; L14863; AAA74628.1; -; Genomic_DNA.
DR EMBL; BA000019; BAB76756.1; -; Genomic_DNA.
DR PIR; AI2437; AI2437.
DR PIR; B53311; B53311.
DR RefSeq; WP_010999183.1; NZ_RSCN01000014.1.
DR AlphaFoldDB; Q06881; -.
DR SMR; Q06881; -.
DR STRING; 103690.17134195; -.
DR EnsemblBacteria; BAB76756; BAB76756; BAB76756.
DR KEGG; ana:all5057; -.
DR eggNOG; COG0511; Bacteria.
DR OMA; IKSPIIG; -.
DR OrthoDB; 1938042at2; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000002483; Chromosome.
DR GO; GO:0009317; C:acetyl-CoA carboxylase complex; IEA:InterPro.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR001249; AcCoA_biotinCC.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR011053; Single_hybrid_motif.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR PRINTS; PR01071; ACOABIOTINCC.
DR SUPFAM; SSF51230; SSF51230; 1.
DR TIGRFAMs; TIGR00531; BCCP; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
PE 1: Evidence at protein level;
KW Biotin; Direct protein sequencing; Fatty acid biosynthesis;
KW Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:8102363"
FT CHAIN 2..182
FT /note="Biotin carboxyl carrier protein of acetyl-CoA
FT carboxylase"
FT /id="PRO_0000146800"
FT DOMAIN 104..180
FT /note="Biotinyl-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01066"
FT REGION 70..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 146
FT /note="N6-biotinyllysine"
FT /evidence="ECO:0000250, ECO:0000255|PROSITE-
FT ProRule:PRU01066"
SQ SEQUENCE 182 AA; 19180 MW; 1D37C61680FC7FDD CRC64;
MPLDFNEIRQ LLTTIAQTDI AEVTLKSDDF ELTVRKAVGV NNSVVPVVTA PLSGVVGSGL
PSAIPIVAHA APSPSPEPGT SRAADHAVTS SGSQPGAKII DQKLAEVASP MVGTFYRAPA
PGEAVFVEVG DRIRQGQTVC IIEAMKLMNE IEADVSGQVI EILVQNGEPV EYNQPLMRIK
PD
