ID   BCCP_PSEAE              Reviewed;         156 AA.
AC   P37799;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Biotin carboxyl carrier protein of acetyl-CoA carboxylase;
DE            Short=BCCP;
GN   Name=accB; Synonyms=fabE; OrderedLocusNames=PA4847;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=7693652; DOI=10.1128/jb.175.21.6881-6889.1993;
RA   Best E.A., Knauf V.C.;
RT   "Organization and nucleotide sequences of the genes encoding the biotin
RT   carboxyl carrier protein and biotin carboxylase protein of Pseudomonas
RT   aeruginosa acetyl coenzyme A carboxylase.";
RL   J. Bacteriol. 175:6881-6889(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: This protein is a component of the acetyl coenzyme A
CC       carboxylase complex; first, biotin carboxylase catalyzes the
CC       carboxylation of the carrier protein and then the transcarboxylase
CC       transfers the carboxyl group to form malonyl-CoA. {ECO:0000250}.
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
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DR   EMBL; L14612; AAA16040.1; -; Unassigned_DNA.
DR   EMBL; AE004091; AAG08232.1; -; Genomic_DNA.
DR   PIR; A49342; A49342.
DR   RefSeq; NP_253534.1; NC_002516.2.
DR   RefSeq; WP_003110495.1; NZ_QZGE01000002.1.
DR   AlphaFoldDB; P37799; -.
DR   SMR; P37799; -.
DR   STRING; 287.DR97_2198; -.
DR   PaxDb; P37799; -.
DR   PRIDE; P37799; -.
DR   EnsemblBacteria; AAG08232; AAG08232; PA4847.
DR   GeneID; 879557; -.
DR   KEGG; pae:PA4847; -.
DR   PATRIC; fig|208964.12.peg.5079; -.
DR   PseudoCAP; PA4847; -.
DR   HOGENOM; CLU_016733_3_1_6; -.
DR   InParanoid; P37799; -.
DR   OMA; IKSPIIG; -.
DR   PhylomeDB; P37799; -.
DR   BioCyc; PAER208964:G1FZ6-4961-MON; -.
DR   UniPathway; UPA00094; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0009317; C:acetyl-CoA carboxylase complex; IEA:InterPro.
DR   GO; GO:0003989; F:acetyl-CoA carboxylase activity; IBA:GO_Central.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR001249; AcCoA_biotinCC.
DR   InterPro; IPR001882; Biotin_BS.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   PRINTS; PR01071; ACOABIOTINCC.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   TIGRFAMs; TIGR00531; BCCP; 1.
DR   PROSITE; PS00188; BIOTIN; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
PE   3: Inferred from homology;
KW   Biotin; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis;
KW   Lipid metabolism; Reference proteome.
FT   CHAIN           1..156
FT                   /note="Biotin carboxyl carrier protein of acetyl-CoA
FT                   carboxylase"
FT                   /id="PRO_0000146810"
FT   DOMAIN          80..156
FT                   /note="Biotinyl-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01066"
FT   MOD_RES         122
FT                   /note="N6-biotinyllysine"
FT                   /evidence="ECO:0000250, ECO:0000255|PROSITE-
FT                   ProRule:PRU01066"
SQ   SEQUENCE   156 AA;  16455 MW;  47C74E737470F78F CRC64;
     MDIRKVKKLI ELLEESGIDE LEIREGEESV RISRHSKTAA QPVYAQAPAF AAPVAAPAPA
     AAAPAAAAAE SAPAAPKLNG NVVRSPMVGT FYRAASPTSA NFVEVGQSVK KGDILCIVEA
     MKMMNHIEAE VSGTIESILV ENGQPVEFDQ PLFTIV