ID   BCCT1_VIBPA             Reviewed;         562 AA.
AC   Q87PP5;
DT   27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Glycine betaine/proline/choline/ectoine transporter VP1456 {ECO:0000305};
GN   OrderedLocusNames=VP1456 {ECO:0000312|EMBL:BAC59719.1};
OS   Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=223926;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RIMD 2210633;
RX   PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA   Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA   Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA   Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT   "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT   distinct from that of V. cholerae.";
RL   Lancet 361:743-749(2003).
RN   [2]
RP   FUNCTION AS A TRANSPORTER, AND INDUCTION.
RC   STRAIN=RIMD 2210633;
RX   PubMed=25344241; DOI=10.1128/aem.02402-14;
RA   Ongagna-Yhombi S.Y., McDonald N.D., Boyd E.F.;
RT   "Deciphering the role of multiple betaine-carnitine-choline transporters in
RT   the halophile Vibrio parahaemolyticus.";
RL   Appl. Environ. Microbiol. 81:351-363(2015).
CC   -!- FUNCTION: Involved in the uptake of osmoprotectants. Can transport
CC       glycine betaine, proline, choline and ectoine.
CC       {ECO:0000269|PubMed:25344241}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- INDUCTION: Induced by NaCl upshock. {ECO:0000269|PubMed:25344241}.
CC   -!- SIMILARITY: Belongs to the BCCT transporter (TC 2.A.15) family.
CC       {ECO:0000305}.
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DR   EMBL; BA000031; BAC59719.1; -; Genomic_DNA.
DR   RefSeq; NP_797835.1; NC_004603.1.
DR   AlphaFoldDB; Q87PP5; -.
DR   SMR; Q87PP5; -.
DR   STRING; 223926.28806447; -.
DR   EnsemblBacteria; BAC59719; BAC59719; BAC59719.
DR   KEGG; vpa:VP1456; -.
DR   PATRIC; fig|223926.6.peg.1392; -.
DR   eggNOG; COG1292; Bacteria.
DR   HOGENOM; CLU_010118_5_0_6; -.
DR   OMA; PEMMART; -.
DR   Proteomes; UP000002493; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR018093; BCCT_CS.
DR   InterPro; IPR000060; BCCT_transptr.
DR   PANTHER; PTHR30047; PTHR30047; 1.
DR   Pfam; PF02028; BCCT; 1.
DR   TIGRFAMs; TIGR00842; bcct; 1.
DR   PROSITE; PS01303; BCCT; 1.
PE   1: Evidence at protein level;
KW   Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Stress response; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..562
FT                   /note="Glycine betaine/proline/choline/ectoine transporter
FT                   VP1456"
FT                   /id="PRO_0000441715"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        322..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        404..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        456..476
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        503..523
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        531..551
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   562 AA;  61407 MW;  1B8126DDE2FCEB73 CRC64;
     MIKFASFLKF RVQINGGRYW SSSPLRSVSN YVKFVFMDNA FKKYSIDTTD YQVGQDNVQK
     WGFDIHNPVF GISAGLVVFC LISLLLVEPV TARDALNGIK NGIIEQFDAF FMWSTNFFLL
     FAVGLLFSPL GKIRLGGKEA TPDHSTVSWL SMLFAAGMGI GLLFWSVAEP TAYFTDWWGT
     PLNAEAYSAD AKSLAMGATM FHWGVHGWSI YALVALALAF FAFNKGLPLS LRAAFYPIFG
     DRAWGWLGHV IDILAVLSTL FGLATSLGLG AQQATSGINH VFGLNGGIGT QMVVIAFVTF
     IAVLSVVRGI DGGVKLLSNV NMIVAFALLI FITFITFDTA MGSLVDTTMA YIQNIIPLSN
     PHGREDETWM HGWTVFYWAW WVSWSPFVGM FIARVSKGRT VREFLFAVIV IPTLVTLVWM
     SVFGGIALDQ VVNKVGELGA NGLTDISLTL FHVYDVLPYS SVISILSIVL ILVFFITSSD
     SGSLVIDSIT AGGKIDAPVP QRIFWACIEG SIAAVMLWVG GKEALQALQS GVVATGLPFT
     FVLLLMCVSL VKGLRTELSA YR