ID   BCCT2_VIBPA             Reviewed;         553 AA.
AC   Q87NZ5;
DT   27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Glycine betaine/proline/choline transporter VP1723 {ECO:0000305};
GN   OrderedLocusNames=VP1723 {ECO:0000312|EMBL:BAC59986.1};
OS   Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=223926;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RIMD 2210633;
RX   PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA   Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA   Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA   Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT   "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT   distinct from that of V. cholerae.";
RL   Lancet 361:743-749(2003).
RN   [2]
RP   FUNCTION AS A TRANSPORTER.
RC   STRAIN=RIMD 2210633;
RX   PubMed=25344241; DOI=10.1128/aem.02402-14;
RA   Ongagna-Yhombi S.Y., McDonald N.D., Boyd E.F.;
RT   "Deciphering the role of multiple betaine-carnitine-choline transporters in
RT   the halophile Vibrio parahaemolyticus.";
RL   Appl. Environ. Microbiol. 81:351-363(2015).
CC   -!- FUNCTION: Involved in the uptake of osmoprotectants. Can transport
CC       glycine betaine, proline and choline. {ECO:0000269|PubMed:25344241}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the BCCT transporter (TC 2.A.15) family.
CC       {ECO:0000305}.
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DR   EMBL; BA000031; BAC59986.1; -; Genomic_DNA.
DR   RefSeq; NP_798102.1; NC_004603.1.
DR   RefSeq; WP_005477808.1; NC_004603.1.
DR   AlphaFoldDB; Q87NZ5; -.
DR   SMR; Q87NZ5; -.
DR   STRING; 223926.28806715; -.
DR   EnsemblBacteria; BAC59986; BAC59986; BAC59986.
DR   GeneID; 1189230; -.
DR   KEGG; vpa:VP1723; -.
DR   PATRIC; fig|223926.6.peg.1643; -.
DR   eggNOG; COG1292; Bacteria.
DR   HOGENOM; CLU_010118_5_0_6; -.
DR   OMA; VHAWAIY; -.
DR   Proteomes; UP000002493; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000060; BCCT_transptr.
DR   PANTHER; PTHR30047; PTHR30047; 1.
DR   Pfam; PF02028; BCCT; 1.
DR   TIGRFAMs; TIGR00842; bcct; 1.
PE   1: Evidence at protein level;
KW   Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..553
FT                   /note="Glycine betaine/proline/choline transporter VP1723"
FT                   /id="PRO_0000441716"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        362..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        443..463
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        490..510
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        515..535
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   553 AA;  59308 MW;  02A728A72F8AA821 CRC64;
     MSTDNNGGIK RPDGKVNAID TDYQIGQDNV ALKVGPFGLD IHNRVFAISG MAIVLFVVAT
     LTFRQQVEPF FAGLRAWLVS NLDWFFLASG NVFVIVCLVL IVTPLGRVRI GGTEATPDYS
     YAGWLAMLFA AGMGIGLVFF GVSEPMSHFS SALGGVNIEN GVRTDWAPLG GAVGDTDAAS
     ALGMAATIYH WALHPWSIYA LLALGLAIFS FNKGLPLTMR SIFYPLFGER VWGWVGHIID
     ILAVVATVFG LATSLGYGAS QAATGLNFLF GVPMTDTTQV VLIVVITALA LISVVAGLDS
     GVKRLSEINM ILAAMLLFFV IIVGPTMAIL TGFFDNIASY ITNIPALSMP FEREDVNYSQ
     GWTAFYWAWW ISWSPFVGMF IARVSRGRSV REFIICVILI PSTVCVLWMT AFGGTAISQY
     VNDGYEAVFN AELPLKLFAM LDVMPFAEIT SVVGIILVVV FFITSSDSGS LVIDTIAAGG
     KVDAPTPQRV FWCTFEGLVA IALMLGGGLA AAQAMAVTTG LPFTIVLLVA TVSLIKGLMD
     EPRLSTKAVK KDK