ID   RSMC_SALTY              Reviewed;         342 AA.
AC   Q8ZJW6;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Ribosomal RNA small subunit methyltransferase C {ECO:0000255|HAMAP-Rule:MF_01862};
DE            EC=2.1.1.172 {ECO:0000255|HAMAP-Rule:MF_01862};
DE   AltName: Full=16S rRNA m2G1207 methyltransferase {ECO:0000255|HAMAP-Rule:MF_01862};
DE   AltName: Full=rRNA (guanine-N(2)-)-methyltransferase RsmC {ECO:0000255|HAMAP-Rule:MF_01862};
GN   Name=rsmC {ECO:0000255|HAMAP-Rule:MF_01862}; OrderedLocusNames=STM4556;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Specifically methylates the guanine in position 1207 of 16S
CC       rRNA in the 30S particle. {ECO:0000255|HAMAP-Rule:MF_01862}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine = H(+) +
CC         N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:42736, Rhea:RHEA-COMP:10213, Rhea:RHEA-COMP:10214,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74269, ChEBI:CHEBI:74481; EC=2.1.1.172;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01862};
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_01862}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01862}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. RsmC family.
CC       {ECO:0000255|HAMAP-Rule:MF_01862}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE006468; AAL23371.1; -; Genomic_DNA.
DR   RefSeq; NP_463412.1; NC_003197.2.
DR   RefSeq; WP_001272276.1; NC_003197.2.
DR   AlphaFoldDB; Q8ZJW6; -.
DR   SMR; Q8ZJW6; -.
DR   STRING; 99287.STM4556; -.
DR   PaxDb; Q8ZJW6; -.
DR   EnsemblBacteria; AAL23371; AAL23371; STM4556.
DR   GeneID; 1256082; -.
DR   KEGG; stm:STM4556; -.
DR   PATRIC; fig|99287.12.peg.4797; -.
DR   HOGENOM; CLU_049581_0_1_6; -.
DR   OMA; RHCQLWQ; -.
DR   PhylomeDB; Q8ZJW6; -.
DR   BioCyc; SENT99287:STM4556-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0052914; F:16S rRNA (guanine(1207)-N(2))-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   Gene3D; 3.40.50.150; -; 2.
DR   HAMAP; MF_01862; 16SrRNA_methyltr_C; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR013675; Mtase_sm_N.
DR   InterPro; IPR023543; rRNA_ssu_MeTfrase_C.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR007848; Small_mtfrase_dom.
DR   Pfam; PF05175; MTS; 1.
DR   Pfam; PF08468; MTS_N; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; Reference proteome; rRNA processing;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..342
FT                   /note="Ribosomal RNA small subunit methyltransferase C"
FT                   /id="PRO_0000369764"
SQ   SEQUENCE   342 AA;  37616 MW;  F034BFD4CBEBE00F CRC64;
     MSAFTPASEV LLRHSDDFEQ SRILFAGDLQ DDLPARFECA ASRAHTQQFH HWQVLSRQMG
     DNVRFSLVAQ ASDVADCDTL IYYWPKNKPE AQFQLMNILS LMPSGVDVFV VGENRSGVRS
     AEPMLADYAP LNKVDSARRC GLYHGRLEKQ PQFSLESWWA EYNIDGLTIK TLPGVFSRDG
     LDVGSQLLLS TLTPHTKGKV LDVGCGAGVL SAALASHSPK VRLTLCDVSA PAVEASRATL
     AANGLEGEVF ASNVFSEVKG RFDMIISNPP FHDGMQTSLD AAQTLIRGAV RHLNSGGELR
     IVANAFLPYP KILDETFGFH EVIAQTGRFK VYRTVMTRQA KK