BCCT3_VIBPA
ID BCCT3_VIBPA Reviewed; 523 AA.
AC Q87NG3;
DT 27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Glycine betaine transporter 1 {ECO:0000305};
GN OrderedLocusNames=VP1905 {ECO:0000312|EMBL:BAC60168.1};
OS Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=223926;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RIMD 2210633;
RX PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT distinct from that of V. cholerae.";
RL Lancet 361:743-749(2003).
RN [2]
RP FUNCTION AS A TRANSPORTER, AND INDUCTION.
RC STRAIN=RIMD 2210633;
RX PubMed=25344241; DOI=10.1128/aem.02402-14;
RA Ongagna-Yhombi S.Y., McDonald N.D., Boyd E.F.;
RT "Deciphering the role of multiple betaine-carnitine-choline transporters in
RT the halophile Vibrio parahaemolyticus.";
RL Appl. Environ. Microbiol. 81:351-363(2015).
CC -!- FUNCTION: Involved in the uptake of the osmoprotectant glycine betaine.
CC {ECO:0000269|PubMed:25344241}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- INDUCTION: Induced by NaCl upshock. {ECO:0000269|PubMed:25344241}.
CC -!- SIMILARITY: Belongs to the BCCT transporter (TC 2.A.15) family.
CC {ECO:0000305}.
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DR EMBL; BA000031; BAC60168.1; -; Genomic_DNA.
DR RefSeq; NP_798284.1; NC_004603.1.
DR RefSeq; WP_005458059.1; NC_004603.1.
DR AlphaFoldDB; Q87NG3; -.
DR SMR; Q87NG3; -.
DR STRING; 223926.28806897; -.
DR EnsemblBacteria; BAC60168; BAC60168; BAC60168.
DR GeneID; 1189412; -.
DR KEGG; vpa:VP1905; -.
DR PATRIC; fig|223926.6.peg.1820; -.
DR eggNOG; COG1292; Bacteria.
DR HOGENOM; CLU_010118_5_2_6; -.
DR OMA; LAWIAMM; -.
DR Proteomes; UP000002493; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR InterPro; IPR018093; BCCT_CS.
DR InterPro; IPR000060; BCCT_transptr.
DR PANTHER; PTHR30047; PTHR30047; 1.
DR Pfam; PF02028; BCCT; 1.
DR TIGRFAMs; TIGR00842; bcct; 1.
DR PROSITE; PS01303; BCCT; 1.
PE 1: Evidence at protein level;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Stress response; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..523
FT /note="Glycine betaine transporter 1"
FT /id="PRO_0000441717"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..392
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 420..440
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 467..487
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 496..516
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 523 AA; 56224 MW; 4CB29BA07F804301 CRC64;
MTKGIDKYSI DSTDYTVGQD NVQKWGFDVH NPVFGISAGF IALFLVAALV LDAHTAKTAL
DGLKWKIIGS FDWLFIIAGN IFVIFCLALI VSPLGKIRLG GKDAVADYSF MSWLAMLFAA
GMGIGLMFWS VAEPVAYFTG WYETPLGVEA NSPEAARLAL GATMFHWGLH PWAIYGVVAL
SLAFFTYNKG LPLSMRSIFY PLLGDRAWGW AGHIVDILAV LATLFGLATS LGLGAQQAAS
GIHHVFGVEP GLGLQIVVIT VVTLLAVVSV VRGIDGGVKV ISNINMVVAF LLLILVGLIG
WAASLGSIPT TLMAYVENII PLSNPFGRTD EAWFQGWTVF YWAWWISWSP FVGMFIARVS
RGRTVREFIT AVLIVPTVVT VVWMSVFGGL AIDQVVNKVG ELGANGLTDV SLAMFQMFDV
LPFGNILSII AVVLVLVFFI TSSDSGSLVI DSITAGGKVD APVLQRVFWA FMEGAIAVAL
LWIGGSEAVQ ALQAGAISTA LPFTFILLAM CVSLLMGMKT ERQ