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BCCT3_VIBPA
ID   BCCT3_VIBPA             Reviewed;         523 AA.
AC   Q87NG3;
DT   27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Glycine betaine transporter 1 {ECO:0000305};
GN   OrderedLocusNames=VP1905 {ECO:0000312|EMBL:BAC60168.1};
OS   Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=223926;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RIMD 2210633;
RX   PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA   Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA   Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA   Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT   "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT   distinct from that of V. cholerae.";
RL   Lancet 361:743-749(2003).
RN   [2]
RP   FUNCTION AS A TRANSPORTER, AND INDUCTION.
RC   STRAIN=RIMD 2210633;
RX   PubMed=25344241; DOI=10.1128/aem.02402-14;
RA   Ongagna-Yhombi S.Y., McDonald N.D., Boyd E.F.;
RT   "Deciphering the role of multiple betaine-carnitine-choline transporters in
RT   the halophile Vibrio parahaemolyticus.";
RL   Appl. Environ. Microbiol. 81:351-363(2015).
CC   -!- FUNCTION: Involved in the uptake of the osmoprotectant glycine betaine.
CC       {ECO:0000269|PubMed:25344241}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- INDUCTION: Induced by NaCl upshock. {ECO:0000269|PubMed:25344241}.
CC   -!- SIMILARITY: Belongs to the BCCT transporter (TC 2.A.15) family.
CC       {ECO:0000305}.
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DR   EMBL; BA000031; BAC60168.1; -; Genomic_DNA.
DR   RefSeq; NP_798284.1; NC_004603.1.
DR   RefSeq; WP_005458059.1; NC_004603.1.
DR   AlphaFoldDB; Q87NG3; -.
DR   SMR; Q87NG3; -.
DR   STRING; 223926.28806897; -.
DR   EnsemblBacteria; BAC60168; BAC60168; BAC60168.
DR   GeneID; 1189412; -.
DR   KEGG; vpa:VP1905; -.
DR   PATRIC; fig|223926.6.peg.1820; -.
DR   eggNOG; COG1292; Bacteria.
DR   HOGENOM; CLU_010118_5_2_6; -.
DR   OMA; LAWIAMM; -.
DR   Proteomes; UP000002493; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR018093; BCCT_CS.
DR   InterPro; IPR000060; BCCT_transptr.
DR   PANTHER; PTHR30047; PTHR30047; 1.
DR   Pfam; PF02028; BCCT; 1.
DR   TIGRFAMs; TIGR00842; bcct; 1.
DR   PROSITE; PS01303; BCCT; 1.
PE   1: Evidence at protein level;
KW   Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Stress response; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..523
FT                   /note="Glycine betaine transporter 1"
FT                   /id="PRO_0000441717"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        251..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        420..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        467..487
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        496..516
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   523 AA;  56224 MW;  4CB29BA07F804301 CRC64;
     MTKGIDKYSI DSTDYTVGQD NVQKWGFDVH NPVFGISAGF IALFLVAALV LDAHTAKTAL
     DGLKWKIIGS FDWLFIIAGN IFVIFCLALI VSPLGKIRLG GKDAVADYSF MSWLAMLFAA
     GMGIGLMFWS VAEPVAYFTG WYETPLGVEA NSPEAARLAL GATMFHWGLH PWAIYGVVAL
     SLAFFTYNKG LPLSMRSIFY PLLGDRAWGW AGHIVDILAV LATLFGLATS LGLGAQQAAS
     GIHHVFGVEP GLGLQIVVIT VVTLLAVVSV VRGIDGGVKV ISNINMVVAF LLLILVGLIG
     WAASLGSIPT TLMAYVENII PLSNPFGRTD EAWFQGWTVF YWAWWISWSP FVGMFIARVS
     RGRTVREFIT AVLIVPTVVT VVWMSVFGGL AIDQVVNKVG ELGANGLTDV SLAMFQMFDV
     LPFGNILSII AVVLVLVFFI TSSDSGSLVI DSITAGGKVD APVLQRVFWA FMEGAIAVAL
     LWIGGSEAVQ ALQAGAISTA LPFTFILLAM CVSLLMGMKT ERQ
 
 
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