ID   BCCT4_VIBPA             Reviewed;         539 AA.
AC   Q87J97;
DT   27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Glycine betaine transporter 2 {ECO:0000305};
GN   OrderedLocusNames=VPA0356 {ECO:0000312|EMBL:BAC61699.1};
OS   Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=223926;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RIMD 2210633;
RX   PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA   Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA   Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA   Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT   "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT   distinct from that of V. cholerae.";
RL   Lancet 361:743-749(2003).
RN   [2]
RP   FUNCTION AS A TRANSPORTER, AND INDUCTION.
RC   STRAIN=RIMD 2210633;
RX   PubMed=25344241; DOI=10.1128/aem.02402-14;
RA   Ongagna-Yhombi S.Y., McDonald N.D., Boyd E.F.;
RT   "Deciphering the role of multiple betaine-carnitine-choline transporters in
RT   the halophile Vibrio parahaemolyticus.";
RL   Appl. Environ. Microbiol. 81:351-363(2015).
CC   -!- FUNCTION: Involved in the uptake of the osmoprotectant glycine betaine.
CC       {ECO:0000269|PubMed:25344241}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- INDUCTION: Induced by NaCl upshock. {ECO:0000269|PubMed:25344241}.
CC   -!- SIMILARITY: Belongs to the BCCT transporter (TC 2.A.15) family.
CC       {ECO:0000305}.
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DR   EMBL; BA000032; BAC61699.1; -; Genomic_DNA.
DR   RefSeq; NP_799866.1; NC_004605.1.
DR   RefSeq; WP_011106258.1; NC_004605.1.
DR   AlphaFoldDB; Q87J97; -.
DR   SMR; Q87J97; -.
DR   STRING; 223926.28808522; -.
DR   EnsemblBacteria; BAC61699; BAC61699; BAC61699.
DR   KEGG; vpa:VPA0356; -.
DR   PATRIC; fig|223926.6.peg.3301; -.
DR   eggNOG; COG1292; Bacteria.
DR   HOGENOM; CLU_010118_6_4_6; -.
DR   OMA; TCFWFSI; -.
DR   Proteomes; UP000002493; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000060; BCCT_transptr.
DR   PANTHER; PTHR30047; PTHR30047; 1.
DR   Pfam; PF02028; BCCT; 1.
PE   1: Evidence at protein level;
KW   Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Stress response; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..539
FT                   /note="Glycine betaine transporter 2"
FT                   /id="PRO_0000441718"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        299..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        348..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        380..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        426..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        480..500
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        503..523
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   539 AA;  58144 MW;  F16921C9691DB7EB CRC64;
     MHGFRALKSE VIMSNMTNAA PHTPIQEADY SAIHPPSLLK RLELTNPVFW LSGSFLSLFV
     LLALTNTESL TAMVNAGFGF ATKYFGAYWQ VLLLLNFLIG LALAFGRTGY VRLGGLAKPD
     IDTFKWLSIV LCTLLAGGGV FWAAAEPIAH FVTAPPLYGE ASPKTSAINA LSQSFMHWGF
     LAWAILGCLS SIVLMHLHYD KGLPLKPRTL LYPIFGDKAI HGWIGNLADA CSIIAVAAGT
     IGPIGFLGLQ ISYALNSLFG FPDNFITQSM VIVAAIVMYT LSALSGVSKG IQLVSRYNII
     LSVLLIGYIL FFGPTSFIID GYVQGVGRMV DNFFPMALYR DDTGWLSWWT VFFWGWFIGY
     GPMMAIFIAR ISRGRTIRQL ILSISIAAPL ITCFWFSIVG GSGLAFELAN PGLISSAFEG
     FNLPAVLLAI TGELPFPMII SVLFLILTTT FIVTTGDSMT YTISVVMTGS AEPNAVIRSF
     WGLMMGVVAI ALISMGSGGI TALQSFIVIT AVPVSFILLP SILKAPGIAN QMAKDQGLV