ABCD2_DICDI
ID ABCD2_DICDI Reviewed; 741 AA.
AC Q8T8P3; Q54C14;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=ABC transporter D family member 2;
DE AltName: Full=ABC transporter ABCD.2;
GN Name=abcD2; ORFNames=DDB_G0293194;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCD family.
CC Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
CC {ECO:0000305}.
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DR EMBL; AY077633; AAL78684.1; -; Genomic_DNA.
DR EMBL; AAFI02000200; EAL60796.1; -; Genomic_DNA.
DR RefSeq; XP_629252.1; XM_629250.1.
DR AlphaFoldDB; Q8T8P3; -.
DR SMR; Q8T8P3; -.
DR STRING; 44689.DDB0214891; -.
DR PaxDb; Q8T8P3; -.
DR PRIDE; Q8T8P3; -.
DR EnsemblProtists; EAL60796; EAL60796; DDB_G0293194.
DR GeneID; 8629134; -.
DR KEGG; ddi:DDB_G0293194; -.
DR dictyBase; DDB_G0293194; abcD2.
DR eggNOG; KOG0060; Eukaryota.
DR HOGENOM; CLU_007587_1_1_1; -.
DR InParanoid; Q8T8P3; -.
DR OMA; IPRWNSK; -.
DR PhylomeDB; Q8T8P3; -.
DR Reactome; R-DDI-1369062; ABC transporters in lipid homeostasis.
DR Reactome; R-DDI-2046105; Linoleic acid (LA) metabolism.
DR Reactome; R-DDI-2046106; alpha-linolenic acid (ALA) metabolism.
DR Reactome; R-DDI-390247; Beta-oxidation of very long chain fatty acids.
DR Reactome; R-DDI-9603798; Class I peroxisomal membrane protein import.
DR PRO; PR:Q8T8P3; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IGC:dictyBase.
DR GO; GO:0005779; C:integral component of peroxisomal membrane; IGC:dictyBase.
DR GO; GO:0005778; C:peroxisomal membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005324; F:long-chain fatty acid transporter activity; IBA:GO_Central.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IBA:GO_Central.
DR GO; GO:0015910; P:long-chain fatty acid import into peroxisome; IBA:GO_Central.
DR GO; GO:0007031; P:peroxisome organization; IBA:GO_Central.
DR GO; GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.
DR GO; GO:0042760; P:very long-chain fatty acid catabolic process; IBA:GO_Central.
DR Gene3D; 1.20.1560.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF06472; ABC_membrane_2; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF90123; SSF90123; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..741
FT /note="ABC transporter D family member 2"
FT /id="PRO_0000370850"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 131..409
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 518..740
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 551..558
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 741 AA; 83689 MW; D0882DE94D1EA623 CRC64;
MEANFVSSAL AGVQNNRSVK RSLDRLKSLF SSGQHQLNGS LGKKVFILLA LGGGAFSLVK
FYKAKNEGSS KQSGLIIDLK DKNSKKDKKR NVTRVDAVFF RRLAKIIRIV IPSLKSKEFL
SLLYLTALLF ARTMLSVSIA EIAGKNAQNL VARKWKEMRN GVLKFALVSI PASFVNASLK
YETDMLALRF RKRLSEYVHK EYLEGVNFYK ASHLGGADRI DNADQRVTSD IEQFCNSMSS
LYTTLFKPFL DLVLFTRKLV VVMGWGSPLL MFSYFIVSGF LKKLIMPPFG RLTAKQSELE
GNYRTVHQRL ITNAEEIAFY DGSRKERQII NLSFGDIYNH TGYVSYLKCL VGIFDGFLVK
YCASIVGYGC MVLPIYTGIR GSSGKDSTEL TKDYIRNTQL MVALSQAIGQ LVLLGNKVTL
MAGYTSRVSE LLEMIKSIKE RGTSQFTIVH EDDVPNPLTN SPVNDKYDTS VDMSSWLEDW
RKRSDQTRIV KRQQSNRSSA SGATTVYGGG TFVEGDFIKF ENVSIVSPEG KLLVENLDFQ
VMPNQNVMIT GPNGSGKSSL FRILGELWPL HCGTVIKPRK EDILFVPQKP YLVLGTLRDQ
IIYPHSHDDM KKLGVTDDDL QHLLATVDPN LTIIRQWNWD DTKDWFTALS GGQKQRIAMA
RLFYHRPQYA ILDECTSAVS DEVEGKIYET CKKLGITLFT VSHRPQLRAY HDYVLLFNGR
GGWEWSKIDH DDDHLKKPLS H
