BCEA_ALKHC
ID BCEA_ALKHC Reviewed; 253 AA.
AC Q9K619; Q9Z9S8;
DT 02-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Bacitracin export ATP-binding protein BceA;
GN Name=bceA; OrderedLocusNames=BH3913;
OS Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS / JCM 9153 / C-125) (Bacillus halodurans).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX NCBI_TaxID=272558;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX PubMed=10086842; DOI=10.1007/s007920050096;
RA Takami H., Nakasone K., Ogasawara N., Hirama C., Nakamura Y., Masui N.,
RA Fuji F., Takaki Y., Inoue A., Horikoshi K.;
RT "Sequencing of three lambda clones from the genome of alkaliphilic Bacillus
RT sp. strain C-125.";
RL Extremophiles 3:29-34(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT and genomic sequence comparison with Bacillus subtilis.";
RL Nucleic Acids Res. 28:4317-4331(2000).
CC -!- FUNCTION: Part of the ABC transporter complex BceAB (TC 3.A.1.123.5)
CC involved in bacitracin export. Responsible for energy coupling to the
CC transport system (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (BceA) and
CC two transmembrane proteins (BceB). {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA75354.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB011838; BAA75354.1; ALT_FRAME; Genomic_DNA.
DR EMBL; BA000004; BAB07632.1; -; Genomic_DNA.
DR PIR; A84139; A84139.
DR RefSeq; WP_010900038.1; NC_002570.2.
DR AlphaFoldDB; Q9K619; -.
DR SMR; Q9K619; -.
DR STRING; 272558.10176538; -.
DR EnsemblBacteria; BAB07632; BAB07632; BAB07632.
DR KEGG; bha:BH3913; -.
DR eggNOG; COG1136; Bacteria.
DR HOGENOM; CLU_000604_1_22_9; -.
DR OMA; WKEYGDQ; -.
DR OrthoDB; 1181903at2; -.
DR Proteomes; UP000001258; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd03255; ABC_MJ0796_LolCDE_FtsE; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017911; MacB_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance; ATP-binding; Nucleotide-binding; Reference proteome;
KW Transport.
FT CHAIN 1..253
FT /note="Bacitracin export ATP-binding protein BceA"
FT /id="PRO_0000091944"
FT DOMAIN 4..243
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 40..47
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 253 AA; 28097 MW; C3451B192F180FD3 CRC64;
MAILEATNIH KSYGTKLNKQ EVLKGIDIRV EKGEFVSIMG ASGSGKTTLL NVLSSIDKLS
NGSIKIEGSE MTRLKEKELA QFRKKHLGFI FQEYNLLDTL TVKENILLPL SITKIPRKAA
DEKFKQVATE LGIYEIKDKY PNEISGGQKQ RASAARAFIH EPSIIFADEP TGALDSKSAS
DLLGKLQQLN EKLRATIVMV THDPVAASYC SRVIFIKDGQ IYTQLHKGDE SRQTFFKDIM
KTQGVLGGVQ NDH
