ID   BCER_BACSU              Reviewed;         231 AA.
AC   O34951;
DT   02-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Sensory transduction protein BceR;
GN   Name=bceR; Synonyms=barA, ytsA; OrderedLocusNames=BSU30400;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9387221; DOI=10.1099/00221287-143-11-3431;
RA   Lapidus A., Galleron N., Sorokin A., Ehrlich S.D.;
RT   "Sequencing and functional annotation of the Bacillus subtilis genes in the
RT   200 kb rrnB-dnaB region.";
RL   Microbiology 143:3431-3441(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   FUNCTION.
RX   PubMed=11717295; DOI=10.1128/jb.183.24.7365-7370.2001;
RA   Kobayashi K., Ogura M., Yamaguchi H., Yoshida K., Ogasawara N., Tanaka T.,
RA   Fujita Y.;
RT   "Comprehensive DNA microarray analysis of Bacillus subtilis two-component
RT   regulatory systems.";
RL   J. Bacteriol. 183:7365-7370(2001).
RN   [4]
RP   FUNCTION.
RC   STRAIN=168;
RX   PubMed=14612242; DOI=10.1016/s0378-1097(03)00738-9;
RA   Bernard R., Joseph P., Guiseppi A., Chippaux M., Denizot F.;
RT   "YtsCD and YwoA, two independent systems that confer bacitracin resistance
RT   to Bacillus subtilis.";
RL   FEMS Microbiol. Lett. 228:93-97(2003).
RN   [5]
RP   FUNCTION.
RC   STRAIN=168;
RX   PubMed=12890034; DOI=10.1046/j.1365-2958.2003.03653.x;
RA   Ohki R., Giyanto X., Tateno K., Masuyama W., Moriya S., Kobayashi K.,
RA   Ogasawara N.;
RT   "The BceRS two-component regulatory system induces expression of the
RT   bacitracin transporter, BceAB, in Bacillus subtilis.";
RL   Mol. Microbiol. 49:1135-1144(2003).
CC   -!- FUNCTION: Member of the two-component regulatory system BceS/BceR
CC       involved in the regulation of bacitracin resistance. When activated by
CC       BceS, binds to the upstream region of the bceAB promoter and up-
CC       regulates the expression of these two genes.
CC       {ECO:0000269|PubMed:11717295, ECO:0000269|PubMed:12890034,
CC       ECO:0000269|PubMed:14612242}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated by BceS. {ECO:0000305}.
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DR   EMBL; AF008220; AAC00253.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15018.1; -; Genomic_DNA.
DR   PIR; G70000; G70000.
DR   RefSeq; NP_390918.1; NC_000964.3.
DR   RefSeq; WP_004399109.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; O34951; -.
DR   SMR; O34951; -.
DR   STRING; 224308.BSU30400; -.
DR   PaxDb; O34951; -.
DR   PRIDE; O34951; -.
DR   EnsemblBacteria; CAB15018; CAB15018; BSU_30400.
DR   GeneID; 936307; -.
DR   KEGG; bsu:BSU30400; -.
DR   PATRIC; fig|224308.179.peg.3297; -.
DR   eggNOG; COG0745; Bacteria.
DR   InParanoid; O34951; -.
DR   OMA; QIISEVW; -.
DR   PhylomeDB; O34951; -.
DR   BioCyc; BSUB:BSU30400-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IBA:GO_Central.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..231
FT                   /note="Sensory transduction protein BceR"
FT                   /id="PRO_0000081031"
FT   DOMAIN          3..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        127..225
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         52
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   231 AA;  26867 MW;  5AC308E2F635AA01 CRC64;
     MFKLLLIEDD ESLFHEIKDR LTGWSYDVYG IQDFSQVLQE FAAVNPDCVI IDVQLPKFDG
     FHWCRLIRSR SNVPILFLSS RDHPADMVMS MQLGADDFIQ KPFHFDVLIA KIQAMFRRVH
     HYNTEPSTIK TWCGAAVDAE QNLVSNDKGS VELTKNEMFI LKQLIEQKNK IVSREELIRS
     LWNDERFVSD NTLTVNVNRL RKKLDALQLG AYIETKVGQG YIAKEEDKFY D