ID   BCES_ALKHC              Reviewed;         334 AA.
AC   Q9K620; Q9Z9S7;
DT   02-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Sensor protein BceS;
DE            EC=2.7.13.3;
GN   Name=bceS; OrderedLocusNames=BH3912;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 55-334.
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=10086842; DOI=10.1007/s007920050096;
RA   Takami H., Nakasone K., Ogasawara N., Hirama C., Nakamura Y., Masui N.,
RA   Fuji F., Takaki Y., Inoue A., Horikoshi K.;
RT   "Sequencing of three lambda clones from the genome of alkaliphilic Bacillus
RT   sp. strain C-125.";
RL   Extremophiles 3:29-34(1999).
CC   -!- FUNCTION: Member of the two-component regulatory system BceS/BceR
CC       involved in the regulation of bacitracin resistance. Activates BceR in
CC       response to extracellular bacitracin (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA75355.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000004; BAB07631.1; -; Genomic_DNA.
DR   EMBL; AB011838; BAA75355.1; ALT_INIT; Genomic_DNA.
DR   PIR; H84138; H84138.
DR   RefSeq; WP_010900037.1; NC_002570.2.
DR   AlphaFoldDB; Q9K620; -.
DR   SMR; Q9K620; -.
DR   STRING; 272558.10176537; -.
DR   EnsemblBacteria; BAB07631; BAB07631; BAB07631.
DR   KEGG; bha:BH3912; -.
DR   eggNOG; COG0642; Bacteria.
DR   HOGENOM; CLU_000445_13_1_9; -.
DR   OMA; YEWLRIH; -.
DR   OrthoDB; 1827824at2; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF02518; HATPase_c; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Kinase; Membrane; Nucleotide-binding;
KW   Phosphoprotein; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix; Two-component regulatory system.
FT   CHAIN           1..334
FT                   /note="Sensor protein BceS"
FT                   /id="PRO_0000074708"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          121..326
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT   MOD_RES         124
FT                   /note="Phosphohistidine; by autocatalysis"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT   CONFLICT        55..60
FT                   /note="VRYKKE -> CDIRAQ (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   334 AA;  38498 MW;  05EC22D4AA471483 CRC64;
     MIKTFIKERG SWILIIIFLQ CFTVFIAYLD SAIPLAPVFY SVFLSSMIFL FFLAVRYKKE
     TTFYRKLEEW DKDLDVTNLA AAESPFERII EQTIVKQTGY LQEKAHRHET ALEQEKDDLL
     AWIHEIKTPL TAMHLIIDRL EDRTIKGQLT YEWMRIHLLL DQQLHQKRIP FMENDLYVEK
     VNLESVLHQE IKTLQSWCIQ KGIGFDLQLE VTDVLTDAKW LSFILRQLLS NAVKYSEASD
     IIIKSDVVSG KTVVEVTDFG RGIEPKDLPR IFEKGFTSTK TDQTNGATGM GLYLAKRVAE
     PLLIDLAVSS TVGEGTTFTL TFPKENEFVR TLGM