BCHA2_ARATH
ID BCHA2_ARATH Reviewed; 3527 AA.
AC F4JHT3; Q9ZQX5;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=BEACH domain-containing protein A2 {ECO:0000303|PubMed:25618824};
DE AltName: Full=BEACH-domain homolog A2 {ECO:0000305};
GN Name=BCHA2 {ECO:0000303|PubMed:25618824};
GN OrderedLocusNames=At4g02660 {ECO:0000312|Araport:AT4G02660};
GN ORFNames=T10P11.5 {ECO:0000312|EMBL:AAC78268.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000312|Proteomes:UP000006548};
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=25618824; DOI=10.1016/j.molp.2014.11.015;
RA Teh O.K., Hatsugai N., Tamura K., Fuji K., Tabata R., Yamaguchi K.,
RA Shingenobu S., Yamada M., Hasebe M., Sawa S., Shimada T.,
RA Hara-Nishimura I.;
RT "BEACH-domain proteins act together in a cascade to mediate vacuolar
RT protein trafficking and disease resistance in Arabidopsis.";
RL Mol. Plant 8:389-398(2015).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC78268.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB77751.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC002330; AAC78268.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161495; CAB77751.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE82211.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM67565.1; -; Genomic_DNA.
DR PIR; T01083; T01083.
DR RefSeq; NP_001319850.1; NM_001340392.1.
DR RefSeq; NP_192175.3; NM_116500.3.
DR SMR; F4JHT3; -.
DR STRING; 3702.AT4G02660.1; -.
DR iPTMnet; F4JHT3; -.
DR PaxDb; F4JHT3; -.
DR PRIDE; F4JHT3; -.
DR EnsemblPlants; AT4G02660.1; AT4G02660.1; AT4G02660.
DR EnsemblPlants; AT4G02660.3; AT4G02660.3; AT4G02660.
DR GeneID; 828210; -.
DR Gramene; AT4G02660.1; AT4G02660.1; AT4G02660.
DR Gramene; AT4G02660.3; AT4G02660.3; AT4G02660.
DR KEGG; ath:AT4G02660; -.
DR Araport; AT4G02660; -.
DR TAIR; locus:2132392; AT4G02660.
DR eggNOG; KOG1786; Eukaryota.
DR eggNOG; KOG1788; Eukaryota.
DR HOGENOM; CLU_000175_4_0_1; -.
DR InParanoid; F4JHT3; -.
DR PRO; PR:F4JHT3; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; F4JHT3; baseline and differential.
DR Genevisible; F4JHT3; AT.
DR GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0007033; P:vacuole organization; IBA:GO_Central.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; -; 1.
DR Gene3D; 1.25.10.10; -; 2.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF48371; SSF48371; 2.
DR SUPFAM; SSF49899; SSF49899; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF81837; SSF81837; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Leucine-rich repeat; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..3527
FT /note="BEACH domain-containing protein A2"
FT /id="PRO_0000434033"
FT REPEAT 1447..1470
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 1499..1522
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 1542..1565
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 1566..1588
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 2001..2024
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 2128..2151
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 2221..2247
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 2313..2336
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT DOMAIN 2704..2871
FT /note="BEACH-type PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01119"
FT DOMAIN 2896..3188
FT /note="BEACH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00026"
FT REPEAT 3272..3311
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 3322..3361
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 3410..3451
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 3483..3522
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REGION 25..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1992..2023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2046..2081
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2658..2680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1995..2023
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2658..2673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3527 AA; 393325 MW; 67F411A174370E92 CRC64;
MKWGTLLKDL KDKVGVAETT ADLIAGEAIS DPTTPPSSSQ ASPSSSFAAL AQHDFNLLSP
TSRDKLKLEL DFKRYWEEFR SSSSEQEKEA ALNLSVNTFC RLVKQHANVD QLVTMLVEPH
IFSFVIGRAF VADVEKLKVS SRKRSLDVEK AIEFFSEVTK DGSSHGANLL TAIEVLASGP
FDKQSLLDSG ILCCLIHTFN AFLTYSVASE GEKTVNYEEK VEGSVVNIMK ALASHPSAAQ
SLIEDDSLQL LFKMVANGSL MAFSRFKVGL VSFHNIQLHK NAMQILGLLL VNDNGSTASY
IRKHHLIKVL LMAVKDFDPD CGDSAYTVGI VDLLLECVEL SYRPETGGVR LKDDIRNAHG
YHFLVQFALI LSSMPKDIVF AFDHSSPHKN RGSNDSKKQP PLSLKTRQND DSEKQQSLSL
NSRQNDEFAL KHFSPALSRL LDVLVTLAQT GPIESSGTST SLLSQTKLTG YSRRQTPSAN
NRYDEPCEQG SGKVKDLEAV QMLQDIFLKA ENKDLQAEVL NRMFKIFTSH LENYRICQEL
KTVPLLVLNM GGFPSSLQEL ILKILEYAVT VVNCVPEQEL LSLCFLLQQP IDSELKHTIL
SFFVKLTSFD QQYKKVLGEV GVLEVLQDDL KQHKLLRGPD QYSGVSNHLD RVPSSPSFKQ
HLDSQDAIIS SPKLMESGSG KLPIFEVERT ITVGWDCMIS LLKNSQVNQE AFRSANGVTV
ILPFLIADEH RTSILRIFSC LITGDIKQVH HEELEALIDV LKSGMVTRVS GDQYKLHYEV
RCDIMGALWR IVGVNGSAQR VFGEATGFSL LLTTLHTFQG EEECRDESHL MVYIKLFKHL
LRLITTAVCE NAINRMKLHS VITSQTFYDL LVESGLLCVD LERHVIQLLL ELALEVLVPP
FLTSESMASA EMAECEKASF LVKTASGQFN PDKQKIYNAG AVRVLIRSLL LCTPKLQLEF
LNLLERLARA SPFNKETLTS AGCVELLLEI IYPFLQGSSP FLSHALKIVE VLGAYRLSPS
ELKMLCRYVM QMRVMNSGPS LIGMMEKLIL MEEDTGLECV SLAPFVEMDM SKTGHASVQV
SLGERSWPPA AGYSFVCWVQ FRNFLTTQEL ESEVYKAGGS SKTPILSGQQ SEQNIFRIFS
VNAISNGSPS YAELYFQEDG ILTLATSNSN SLSFSGLETE EGKWHHLAVV HSKPNALAGL
FQASVAYVYI DGKLRHMGKL GYSPSPVGKS LQVIIGTSAT CARACGGDSM AILDLLDTDM
SSGIQKFEDS NRQGDSKAHC SGIVWDLDRL GNLSIQLPGK KLIFAFDGTC SEFMRATGSF
SLVNLVDPLS AAASLIGGIP RFGRLVGNVS LCRQNVIGNS IRPVGGMAVV LALVEAAESR
DMLHMALSLL ACALHQNSQN VKDMETYTGY HLLALFLRPK MALFDMQCLE IFFQISACEA
FFSEPKKLES GQTTISMSPT EIIPENNYED PTLCKFQYET SSVGSHGDMD DFSGRKDSFS
HLSELEMGDN PVETSNCIVL SNADMVEHVL LDWTLWVTAP VSIQIASLGF LENLISILWY
RSHNLAILRQ INLVKHLLVT LQRGDVEVLV LEKLVILLRC ILENGFLTPE LEDVVRFAIM
TFNPPEIKSQ NSSMRESMGK HVIVRNLVLE MLIDLQVTIK AEELLEQWHK TVSSKLITYF
LDGAVHPSSM RWIMTLLGVC LTSSPNFSLK FFASGGYQGL VRVLQSFYDS PDIYYILFCL
IFGKPVYPRL PEVRMLDFHA LMPDDGSHVE LNFVDLLDSV VAMAKSTFDR LIMQSMLAHQ
SGNLSQVSAR CVAELVEGYA DMTGELQGKA LMHKTYAARL MGGEASAPAT ATSVIRFMVD
LAKMCPQFSA ACKNTEFLQK CADLYFSCVR AFHAVKLAKQ LSMKAEEQNI TGGDDSSVEG
NFCRVSHQDM STKTSISAGS FPQDQTSSVI SVDMYIPSDY VAVDKVENFL TTPPGESNKS
FQGREYIAKQ DGDHVGSVSA SSEMKSLDLT GSSSQVQPID SRSSESFSML ESPLLSEKSS
LEVPFIPSPS KSSTISTPHP SHISVSEFDA SSDQSSGSQG SSAVHTLFTI SPKVLLETDE
SGYGGGPCSA GASAVLDFMA EVCADIMTEQ IKAVQALESI LEMLPLYVDP ECVVVFQGLC
LSRVMNYLER RFLRDDEEDD KKLDKRKWSA NLDAFCWMIV DRVYMGAFPQ PTGVLRTLEF
LLSILQLANK DGRVEEVTSS GKGLLSIGRA TRQLDAYVHS ILKNTNRTIL YCFLPSFLIT
IGEEDLPSRL GLLVESTKKQ TSKLSGKESG IDVSAVLQLL VANKNIILCP SNLDTDLNCC
LCVNLISLLH DQRKNVQNMA SNIIKYLLVH RKSALEDLLV KKPHRGQKFD VLHGGFDRLL
TGNLPEFSKW LESSEQIITK VLEQGAAVMW IQYIAGSAKF PDVRMKGMDG RRTREMGRKL
RDTSKLDLKH WEQVNERRYA LEVVRDAMSA ELRVVRQNKY GLILHAESVW PTHLQQLVHE
RGIFPMRISH GVEDLKWQLC PIEGPYRMRK KLERCKLKID SLHNLLEGKL ELGEIELLKS
KSEDGLVISD MDSEPAFLLS ELYSESFSEE ADDLKDVPSA RNGWNNDRAT STNAASLHNS
LSFGGKSSST AVSVPISVNT DEKSETGSPI KSSSGKMDEI KHVEEESEKE LKDDGEYLIR
PYLEHLEKIR FRYNCERVVG LDKHDGIFLI GELCLYVIEN FYIDDHGCIC EKECEDELSI
IDQAQGLKKQ FHGSLESKSK SSTLWSTTIK IGAVGGRAWA YGGGAWGKEK VRVTGNLPHP
WHMWKLDSVH EILKRDYELR RVAVEIFSMD GCNDLLVFHK KEREEVFRNL LAMNLPRNSM
LDTTISGSAK QESKEGSRLF KLMAKSFTKR WQNGEISNFQ YLMHLNTLAG RGYSDLTQYP
VFPWILADYD GESLDLSDPN NFRKLDKPMG CQTPEGEEEF RKRYESWDDP EVPQFHYGSH
YSSAGIVLFY LIRLPPFSAE NQKLQGGQFD HADRLFNSIR ETWLSAAGKG NTSDVKELIP
EFFYMPEFLE NRFNLDLGEK QSGDKVGDVI LPPWARGSVR EFIRKHREAL ESDYVSENLH
HWIDLIFGHK QRGKAAENAV NVFYHYTYEG NVDVDAVTDP AMKASILAQI NHFGQTPKQL
FQKPHVKRRT DRKVPPHPLK HSMHLVPRNI RKCSSSINQI ITFNDKLLLT GANCLLKPRG
YKKYIRWGFP DRTLRFMSYD QDKLLSTHEN LHEGNQIQCA GVSHDGRIVV TGAEDGLVSV
WRVSKDGPRG SRRLRLEKSL CAHTAKVICL RVSQPYMMIA SSSDDCTVII WDLSSLSFVR
QLPNFSVPVT VVYINDLTGE IVTAAGSVLA VWSINGDCLS VVNTSQLPTD LIVSVAGSTF
SDWLETTWYV TGHQSGALKV WRMVHCTDPV SVPSKTPSNR TGGLNLGNQK PEYKLLLHKE
LKFHKQPVTS LHLTTDLKQL LSGDSAGHLL SWTVPDEILK ASLKKAS
