BCHC2_ARATH
ID BCHC2_ARATH Reviewed; 3001 AA.
AC F4IG73; O64634;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=BEACH domain-containing protein C2 {ECO:0000303|PubMed:25618824};
DE AltName: Full=BEACH-domain homolog C2 {ECO:0000305};
GN Name=BCHC2 {ECO:0000303|PubMed:25618824};
GN OrderedLocusNames=At2g45540 {ECO:0000312|Araport:AT2G45540};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000312|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=25618824; DOI=10.1016/j.molp.2014.11.015;
RA Teh O.K., Hatsugai N., Tamura K., Fuji K., Tabata R., Yamaguchi K.,
RA Shingenobu S., Yamada M., Hasebe M., Sawa S., Shimada T.,
RA Hara-Nishimura I.;
RT "BEACH-domain proteins act together in a cascade to mediate vacuolar
RT protein trafficking and disease resistance in Arabidopsis.";
RL Mol. Plant 8:389-398(2015).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F4IG73-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F4IG73-2; Sequence=VSP_057891;
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DR EMBL; AC003680; AAC06163.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10567.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10568.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM63206.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM63207.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM63208.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM63209.1; -; Genomic_DNA.
DR PIR; T00867; T00867.
DR RefSeq; NP_001189752.1; NM_001202823.2. [F4IG73-1]
DR RefSeq; NP_001318429.1; NM_001337139.1. [F4IG73-2]
DR RefSeq; NP_001325311.1; NM_001337140.1. [F4IG73-2]
DR RefSeq; NP_001325312.1; NM_001337142.1. [F4IG73-2]
DR RefSeq; NP_001325313.1; NM_001337141.1. [F4IG73-2]
DR RefSeq; NP_182078.1; NM_130116.4. [F4IG73-2]
DR SMR; F4IG73; -.
DR STRING; 3702.AT2G45540.2; -.
DR iPTMnet; F4IG73; -.
DR PaxDb; F4IG73; -.
DR PRIDE; F4IG73; -.
DR ProMEX; F4IG73; -.
DR ProteomicsDB; 240854; -. [F4IG73-1]
DR EnsemblPlants; AT2G45540.1; AT2G45540.1; AT2G45540. [F4IG73-2]
DR EnsemblPlants; AT2G45540.2; AT2G45540.2; AT2G45540. [F4IG73-1]
DR EnsemblPlants; AT2G45540.3; AT2G45540.3; AT2G45540. [F4IG73-2]
DR EnsemblPlants; AT2G45540.4; AT2G45540.4; AT2G45540. [F4IG73-2]
DR EnsemblPlants; AT2G45540.5; AT2G45540.5; AT2G45540. [F4IG73-2]
DR EnsemblPlants; AT2G45540.6; AT2G45540.6; AT2G45540. [F4IG73-2]
DR GeneID; 819162; -.
DR Gramene; AT2G45540.1; AT2G45540.1; AT2G45540. [F4IG73-2]
DR Gramene; AT2G45540.2; AT2G45540.2; AT2G45540. [F4IG73-1]
DR Gramene; AT2G45540.3; AT2G45540.3; AT2G45540. [F4IG73-2]
DR Gramene; AT2G45540.4; AT2G45540.4; AT2G45540. [F4IG73-2]
DR Gramene; AT2G45540.5; AT2G45540.5; AT2G45540. [F4IG73-2]
DR Gramene; AT2G45540.6; AT2G45540.6; AT2G45540. [F4IG73-2]
DR KEGG; ath:AT2G45540; -.
DR Araport; AT2G45540; -.
DR TAIR; locus:2043679; AT2G45540.
DR eggNOG; KOG1787; Eukaryota.
DR InParanoid; F4IG73; -.
DR OMA; NMPINES; -.
DR OrthoDB; 101142at2759; -.
DR PRO; PR:F4IG73; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IG73; baseline and differential.
DR Genevisible; F4IG73; AT.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; -; 1.
DR Gene3D; 2.130.10.10; -; 2.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF49899; SSF49899; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF81837; SSF81837; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1..3001
FT /note="BEACH domain-containing protein C2"
FT /id="PRO_0000434036"
FT DOMAIN 2151..2260
FT /note="BEACH-type PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01119"
FT DOMAIN 2275..2564
FT /note="BEACH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00026"
FT REPEAT 2679..2718
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 2721..2760
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 2802..2841
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 2842..2881
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 2953..2992
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REGION 43..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 103..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1846..1868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2039..2071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2101..2132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2193..2212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1024..1051
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2101..2115
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2116..2132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2193..2207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 48
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19376835"
FT VAR_SEQ 915..978
FT /note="HCKFNANASAVCSLLALLLIKLVPLFRSQIMYMNSRKPSYNGLHGEMWVISR
FT ENGLTDCTRLCW -> ARVLHLMYR (in isoform 2)"
FT /id="VSP_057891"
SQ SEQUENCE 3001 AA; 328092 MW; C47C1279134ADBEC CRC64;
MEDDDERKLP EADIANPLHN RIEAFDTTLQ GISSADRAFK DDDFEQVSLG DQEKAANESQ
GDLQEPGSFS NSDHGRSSFG GTEVVTYQLS GTQEMYDLMP MDDVQSDRLS SPGPEREAAY
SMQQSLSETS LDSVHHPESG YSPVHSPQKP KPKATVPNVS PELLHLVDSA IMGKPESLDK
LKNVVCGIEN FGCGEESEAT AFLVVDSLIA TMGGVESFEE DEDSNPPSVM LNSRAAIVSG
ELIPWLPGLG DNVNFMSPRT RMVRGLLVIL RSCTRNRAMC STAGLLGVLL RSVEAIISKD
VDMKWNAAAI LLLCIQHLAG HSLSVDDLHR WLQVIKAAIT TAWSSPLMLA LEKAMSGKES
RGPACTFEFD GESSGLLGPG ESRWPFTNGY AFATWIYIES FADTLNAATA AAAIAAAAAA
KSGKTSAMSA AAAASALAGE GTAHMPRLFS FLSADNQGIE AYFHAQFLVV ESGSGKGRKS
SLHFTHAFKP QCWYFIGLEH SCKQGLLGKA ESELRLYIDG SLYESRPFDF PRISKPLSFC
CIGTNPPPTM AGLQRRRRQC PLFAEMGPVY IFKEPIGPER MARLASRGGD VLPCFGNGAG
LPWLATNDYV RNKAEESSIL DADIGGYTHL LYHPCLLSGR FCPDASLSGA AGTLRRPAEV
LGQVHVATRM KPVESFWALA YGGPMSLLPL TVSSVHKDSL EPCLGNLPLS LSTVTLAAPV
FRIMSVAIQH PGNNEELCRT QGPEILARIL SYLLHSLASL DRKHDGVGEE ELVAAIVSLC
QSQKINHVLK VQLFRTLLLD LKIWSLCNYG LQKKLLSSLQ DMVFTEATAM RDAEAIQLLL
DGCRRCYWMI SEKDSETTFP LDGNTRQMGE LNALIDELLV IIELLMGAAS PSLAADDLRR
LLGFIIDSPQ PNQVHCKFNA NASAVCSLLA LLLIKLVPLF RSQIMYMNSR KPSYNGLHGE
MWVISRENGL TDCTRLCWLV VQPNAARAQM FAEVFITSGG IETLLVLLQR EAKTGEDNVL
AMGRSGKRSS TDPSEKSPYN ESGSVKQLDS NPHDNEIGFD LPGPDGNSVE DDNVGSLNVP
ESVRQEKEHG STPVVCDSDS VSISNSINTE RLSAEIGGIS LSISADSARN NVYNVDNSDA
VVVGIIRLIG ALISSGHLTF DFDARSDVTS NILGSGLHEN GGTMFDDKVA LLLFALLKAF
QAAPNRLMTD NVYTTLLGAS INASSTEDGL NFYDSGHRFE HSQLLLVLLR SLPSASKALQ
SRALQDLLFL ACSHPENRSS LTTMEEWPEW ILEILISNYE KDAGKQSASV GSCEVEDMIH
NFLIIMLEHS MRQKDGWKDI EATIHCAEWL SIVGGSSTGE QRIRREESLP IFKRRLFGGL
LDFAARELQA QTQVIAAAAA GVAAEGLAPK DAKAGAENAA QLSVFLVENA IVILMLVEDH
LRSQSKQTCA TNAVASPSPL KKRTSTLTAI GESSEISSSR ASLSSDSGKV PLDILASMAD
SSGQISAVAM ERLTAASAAE PYESVSCAFV SYGSCAMDLA EGWKYRSRLW YGVGLPSKPS
SLGGGGSGSD SWKSTLEKDA HGNWIELPLV KKSVSMLQAL LLDESGLGGG LGIGGGSGTG
MGGMTALYQL LDSDQPFLCM LRMVLLSMRE EDYGEDNMLM RNLSSERSSG NSVTLDSGSQ
MSMRQSRSAL LWSVLSPIIN MPISDSKRQR VLVTACVLYS EVWHAISRDR RPLRKQYIEA
IVPPFIAVLR RWRPLLAGIH ELATADGMNP LVVDDRALAA DALPVEGALS MVTPEWAAAF
ASPPAAMSLA MIAAGAAGWE APPPPTPSHL RRDSSMLERK TAKLQTFSSF QKPLEPPNNN
APPRPRDKAA AKAAALAAAR DLERNAKIGS GRGLSAVAMA TSAQRRNIGD MERLQRWNTS
EAMGVAWMEC LQPVDTKSVY GKDFNALSYK FIAVLVASFA LARNMQRSEI DRRMQDDIIA
ANRLCLGSRA WRKLIRYLAE MRCFFGPFGD GICSPERVFW KLDSMESFSR MRQSIRRNYS
GTDHHGAAAD YDDQTETKSD NGSKGSQSNP PVVAAEVILM EIAYEEDEHG EGDQLDVKGN
AEEHKRDEGR ISGSHEHASR TSAGNSDPRT SNDLEMVRDS SVVAPGFVPS ELDERILLEL
PTSMVRPLRV VKGTFQITTR RINFIVDNRE SQNLADHSDE SQSGDQEKDR SWPMSSLHQI
YSRRYLLRRS ALELFMVDRS NFFFDFGNTE GRRNAYRAIV QARPPHLNNI YLATQRPEQL
LRRTQLMERW ARWEISNFEY LMQLNTLAGR SYNDITQYPV FPWIISDNSS ESLDLSNPST
FRDLSKPIGA LNPERLKKFQ ERYSSFEDPV IPKFHYGSHY SSAGAVLYYL ARVEPFTTLS
IQLQGGKFDH ADRMFSDFPG TWNGVLEDMS DVKELVPELF YLPEVLTNEN SIDFGTTQLG
EKLDAVKLPP WAKNPVDFVH KQRRALESEH VSAHLHEWID LIFGYKQRGK EAIMANNVFF
YITYEGTVDI DKITDPVQQR ATQDQIAYFG QTPSQLLTVP HMKRMPLKDV LHMQTIFRNP
KEIKPYTVQT PERCNLPASA IQASSDSVVI VDMNVPAARV AQHKWQPNTP DGQGTPFLFH
HGKATTTSTS GSLMRMFKGP ASSGTGDWQF PQAQAFASSG IRSSSVIAIT SDGEIITGGH
ADNSIKLVSS DGAKTLETAF GHCAPVTCLA LSPDNNFLVT GSRDSTVLLW RIHKAFTSRT
SVSEPSTGSG APSSTSNTNL ANTLANKGKK CRLEGPIQVL RGHRRELVCC CVSSDQGVVV
SSSESSDVLL HSIRKGRLIR RLVGVKADSL CISSDGVIMA WSSSEGSISV FTINGVLIAK
AKFPLFCSVG CMEISMDGQN ALIGMNSCSN SDYSSSNDTS KDSKEIERLD VPSPSICFLN
LYTLQVFHVL KLGQGQDITA LALNVDNTNL LVSTEDKQLI IFTDPALSLK VVDQMLKLGW
E
