RSMH_TREPR
ID RSMH_TREPR Reviewed; 295 AA.
AC Q8KTR3;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Ribosomal RNA small subunit methyltransferase H;
DE EC=2.1.1.199;
DE AltName: Full=16S rRNA m(4)C1402 methyltransferase;
DE AltName: Full=rRNA (cytosine-N(4)-)-methyltransferase RsmH;
GN Name=rsmH; Synonyms=mraW;
OS Tremblaya princeps.
OC Bacteria; Proteobacteria; Betaproteobacteria; Candidatus Tremblaya.
OX NCBI_TaxID=189385;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12088995; DOI=10.1128/aem.68.7.3198-3205.2002;
RA Baumann L., Thao M.L., Hess J.M., Johnson M.W., Baumann P.;
RT "The genetic properties of the primary endosymbionts of mealybugs differ
RT from those of other endosymbionts of plant sap-sucking insects.";
RL Appl. Environ. Microbiol. 68:3198-3205(2002).
CC -!- FUNCTION: Specifically methylates the N4 position of cytidine in
CC position 1402 (C1402) of 16S rRNA. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) +
CC N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:42928, Rhea:RHEA-COMP:10286, Rhea:RHEA-COMP:10287,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:74506, ChEBI:CHEBI:82748; EC=2.1.1.199;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. RsmH family.
CC {ECO:0000305}.
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DR EMBL; AF481102; AAM75985.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8KTR3; -.
DR SMR; Q8KTR3; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 1.10.150.170; -; 1.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR002903; RsmH.
DR InterPro; IPR023397; SAM-dep_MeTrfase_MraW_recog.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11265; PTHR11265; 1.
DR Pfam; PF01795; Methyltransf_5; 1.
DR PIRSF; PIRSF004486; MraW; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
DR SUPFAM; SSF81799; SSF81799; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Methyltransferase; rRNA processing; S-adenosyl-L-methionine;
KW Transferase.
FT CHAIN 1..295
FT /note="Ribosomal RNA small subunit methyltransferase H"
FT /id="PRO_0000108601"
FT BINDING 34..36
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 54
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 76
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 97
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 104
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
SQ SEQUENCE 295 AA; 31920 MW; C127F585594FF9C0 CRC64;
MVRREHRSVM IQEVVDNLLT NTSGLYIDAT YGTGGHSTAL LGCLGPQGKV IALDCDQSIR
FDHTSDPRAA AGHANFRELS GYLRCAEIYG ADGIVADLGP SATQVHDAQR GLSYLHPGPI
DMRVDPTLRV PLSGRLMRTG LGTLHSSLRC HGFSGRTKAA ASRILHIVRK ARYTTTLDVA
TAACGLHNQG KHMAADAFRA LRSMANSEPQ CLRSLVRHAP AVLKPGGRLL ILTFDSFGER
MVRASIEHAS CLVLMRTVAP TQREVDTNPG ARSSLLHVLR RTGNPRSAAP QHTRP
