RSMN_RAT
ID RSMN_RAT Reviewed; 240 AA.
AC P63164; P14648; P17135;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Small nuclear ribonucleoprotein-associated protein N;
DE Short=snRNP-N;
DE AltName: Full=Sm protein D;
DE Short=Sm-D;
DE AltName: Full=Sm protein N;
DE Short=Sm-N;
DE Short=SmN;
GN Name=Snrpn; Synonyms=Smn;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Cerebellum;
RX PubMed=2522186; DOI=10.1093/nar/17.4.1733;
RA Schmauss C., McAllister G., Ohosone Y., Hardin J.A., Lerner M.R.;
RT "A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human
RT B/B'.";
RL Nucleic Acids Res. 17:1733-1743(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2526016; DOI=10.1002/j.1460-2075.1989.tb03489.x;
RA McAllister G., Roby-Shemkovitz A., Amara S.G., Lerner M.R.;
RT "cDNA sequence of the rat U snRNP-associated protein N: description of a
RT potential Sm epitope.";
RL EMBO J. 8:1177-1181(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2532363; DOI=10.1073/pnas.86.24.9778;
RA Li S., Klein E.S., Russo A.F., Simmons D.M., Rosenfeld M.G.;
RT "Isolation of cDNA clones encoding small nuclear ribonucleoparticle-
RT associated proteins with different tissue specificities.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:9778-9782(1989).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=1981744; DOI=10.1159/000111865;
RA Esposito F., Ammendola R., Duilio A., Costanzo F., Giordano M.,
RA Zambrano N., D'Agostino P., Russo T., Cimino F.;
RT "Isolation of cDNA fragments hybridizing to rat brain-specific mRNAs.";
RL Dev. Neurosci. 12:373-381(1990).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in tissue-specific alternative RNA processing
CC events.
CC -!- SUBUNIT: Interacts with TDRD3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Brain specific.
CC -!- MISCELLANEOUS: Encoded on a bicistronic transcript that code for two
CC proteins, SNRPN and SNURF.
CC -!- SIMILARITY: Belongs to the snRNP SmB/SmN family. {ECO:0000305}.
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DR EMBL; M29293; AAA42157.1; -; mRNA.
DR EMBL; M29294; AAA42158.1; -; mRNA.
DR EMBL; BC087671; AAH87671.1; -; mRNA.
DR PIR; A34503; A34503.
DR RefSeq; NP_112379.1; NM_031117.2.
DR AlphaFoldDB; P63164; -.
DR SMR; P63164; -.
DR STRING; 10116.ENSRNOP00000021763; -.
DR iPTMnet; P63164; -.
DR PhosphoSitePlus; P63164; -.
DR jPOST; P63164; -.
DR PaxDb; P63164; -.
DR PRIDE; P63164; -.
DR Ensembl; ENSRNOT00000088874; ENSRNOP00000071994; ENSRNOG00000054391.
DR GeneID; 81781; -.
DR KEGG; rno:81781; -.
DR UCSC; RGD:621306; rat.
DR CTD; 6638; -.
DR RGD; 621306; Snrpn.
DR eggNOG; KOG3168; Eukaryota.
DR GeneTree; ENSGT00940000158222; -.
DR HOGENOM; CLU_076902_1_0_1; -.
DR InParanoid; P63164; -.
DR OMA; FAPQRPG; -.
DR OrthoDB; 1630470at2759; -.
DR PhylomeDB; P63164; -.
DR TreeFam; TF314232; -.
DR Reactome; R-RNO-72163; mRNA Splicing - Major Pathway.
DR PRO; PR:P63164; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000059764; Expressed in cerebellum and 18 other tissues.
DR Genevisible; P63164; RN.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005685; C:U1 snRNP; IDA:RGD.
DR GO; GO:0005686; C:U2 snRNP; IDA:RGD.
DR GO; GO:0071004; C:U2-type prespliceosome; IBA:GO_Central.
DR GO; GO:0005687; C:U4 snRNP; IBA:GO_Central.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IBA:GO_Central.
DR GO; GO:0005682; C:U5 snRNP; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0009725; P:response to hormone; IEP:RGD.
DR InterPro; IPR001163; LSM_dom_euk/arc.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR017131; snRNP-assoc_SmB/SmN.
DR Pfam; PF01423; LSM; 1.
DR PIRSF; PIRSF037187; snRNP_SmB/SmN; 1.
DR SMART; SM00651; Sm; 1.
DR SUPFAM; SSF50182; SSF50182; 1.
PE 2: Evidence at transcript level;
KW Methylation; Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW RNA-binding.
FT CHAIN 1..240
FT /note="Small nuclear ribonucleoprotein-associated protein
FT N"
FT /id="PRO_0000125525"
FT REPEAT 175..181
FT REPEAT 191..196
FT REPEAT 216..221
FT REPEAT 222..228
FT REPEAT 230..236
FT REGION 163..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..236
FT /note="Repeat-rich region"
FT COMPBIAS 169..240
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 108
FT /note="Asymmetric dimethylarginine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P14678"
FT MOD_RES 108
FT /note="Dimethylated arginine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P14678"
FT MOD_RES 108
FT /note="Omega-N-methylarginine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P63163"
FT MOD_RES 112
FT /note="Asymmetric dimethylarginine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P14678"
FT MOD_RES 112
FT /note="Dimethylated arginine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P14678"
FT MOD_RES 112
FT /note="Omega-N-methylarginine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P14678"
FT MOD_RES 147
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:P14678"
FT MOD_RES 172
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:P63162"
FT CONFLICT 35..52
FT /note="DKHMNLILCDCDEFRKIK -> KDLEILVLTTAIVEQQSW (in Ref. 3;
FT AAA42158)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 240 AA; 24614 MW; 9A176D043561474C CRC64;
MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK IKPKNAKQPE
REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA AGGPGVGRAA GRGVPAGVPI
PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV AAAAVAATAS IAGAPTQYPP GRGTPPPPVG
RATPPPGIMA PPPGMRPPMG PPIGLPPARG TPIGMPPPGM RPPPPGIRGP PPPGMRPPRP
