RSP1_CAEEL
ID RSP1_CAEEL Reviewed; 312 AA.
AC Q23121; Q8I106; Q8I107;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Probable splicing factor, arginine/serine-rich 1;
DE AltName: Full=CeSRp75;
DE AltName: Full=RNA-binding protein srp-5;
GN Name=rsp-1; Synonyms=srp-5 {ECO:0000303|PubMed:10906451};
GN ORFNames=W02B12.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1] {ECO:0000312|EMBL:CAA91395.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2 {ECO:0000312|EMBL:CAA91395.1};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP IDENTIFICATION, AND FUNCTION.
RX PubMed=10747030; DOI=10.1093/emboj/19.7.1625;
RA Longman D., Johnstone I.L., Caceres J.F.;
RT "Functional characterization of SR and SR-related genes in Caenorhabditis
RT elegans.";
RL EMBO J. 19:1625-1637(2000).
RN [3] {ECO:0000305}
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=10906451; DOI=10.1016/s0925-4773(00)00339-7;
RA Kawano T., Fujita M., Sakamoto H.;
RT "Unique and redundant functions of SR proteins, a conserved family of
RT splicing factors, in Caenorhabditis elegans development.";
RL Mech. Dev. 95:67-76(2000).
CC -!- FUNCTION: Plays a functionally redundant role in spermatogenesis and
CC growth rate control. {ECO:0000269|PubMed:10747030,
CC ECO:0000269|PubMed:10906451}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10906451}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=a {ECO:0000303|PubMed:9851916};
CC IsoId=Q23121-1; Sequence=Displayed;
CC Name=b {ECO:0000303|PubMed:9851916};
CC IsoId=Q23121-2; Sequence=VSP_051626, VSP_051627;
CC Name=c {ECO:0000303|PubMed:9851916};
CC IsoId=Q23121-3; Sequence=VSP_051628, VSP_051629;
CC -!- PTM: Extensively phosphorylated on serine residues in the RS domain.
CC {ECO:0000250|UniProtKB:Q9NEW6}.
CC -!- MISCELLANEOUS: RNA-mediated interference (RNAi) of rsp-1 and rsp-2
CC result in reduced brood sizes and abnormal egg-laying behavior, and the
CC presence of unusual vacuolated structures in some of the secondary
CC spermatocytes, spermatids and spermatozoa.
CC -!- SIMILARITY: Belongs to the splicing factor SR family. {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z66521; CAA91395.1; -; Genomic_DNA.
DR EMBL; Z66521; CAD59159.1; -; Genomic_DNA.
DR EMBL; Z66521; CAD59160.1; -; Genomic_DNA.
DR PIR; T26085; T26085.
DR RefSeq; NP_001317731.1; NM_001330960.1.
DR RefSeq; NP_496442.1; NM_064041.4. [Q23121-1]
DR RefSeq; NP_871913.1; NM_182113.6.
DR AlphaFoldDB; Q23121; -.
DR SMR; Q23121; -.
DR BioGRID; 40055; 3.
DR STRING; 6239.W02B12.3a; -.
DR iPTMnet; Q23121; -.
DR EPD; Q23121; -.
DR PaxDb; Q23121; -.
DR PeptideAtlas; Q23121; -.
DR EnsemblMetazoa; W02B12.3a.1; W02B12.3a.1; WBGene00004698. [Q23121-1]
DR EnsemblMetazoa; W02B12.3b.1; W02B12.3b.1; WBGene00004698. [Q23121-2]
DR EnsemblMetazoa; W02B12.3b.2; W02B12.3b.2; WBGene00004698. [Q23121-2]
DR EnsemblMetazoa; W02B12.3b.3; W02B12.3b.3; WBGene00004698. [Q23121-2]
DR EnsemblMetazoa; W02B12.3c.1; W02B12.3c.1; WBGene00004698.
DR GeneID; 174748; -.
DR KEGG; cel:CELE_W02B12.3; -.
DR UCSC; W02B12.3a; c. elegans. [Q23121-1]
DR CTD; 174748; -.
DR WormBase; W02B12.3a; CE03763; WBGene00004698; rsp-1. [Q23121-1]
DR WormBase; W02B12.3b; CE32944; WBGene00004698; rsp-1. [Q23121-2]
DR WormBase; W02B12.3c; CE51629; WBGene00004698; rsp-1.
DR eggNOG; KOG0106; Eukaryota.
DR GeneTree; ENSGT00940000156213; -.
DR HOGENOM; CLU_012062_34_2_1; -.
DR InParanoid; Q23121; -.
DR OMA; RKIKMID; -.
DR OrthoDB; 1315388at2759; -.
DR PhylomeDB; Q23121; -.
DR PRO; PR:Q23121; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00004698; Expressed in embryo and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003723; F:RNA binding; ISS:WormBase.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0008406; P:gonad development; IGI:UniProtKB.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:WormBase.
DR GO; GO:0040009; P:regulation of growth rate; IGI:UniProtKB.
DR GO; GO:0008380; P:RNA splicing; NAS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; IGI:UniProtKB.
DR CDD; cd12337; RRM1_SRSF4_like; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR035585; RRM1_SRSF4-like.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Developmental protein; Differentiation;
KW Growth regulation; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; RNA-binding; Spermatogenesis.
FT CHAIN 1..312
FT /note="Probable splicing factor, arginine/serine-rich 1"
FT /id="PRO_0000081948"
FT DOMAIN 3..73
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 129..202
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 69..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..254
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..282
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 144..150
FT /note="DLKDQVR -> VCKTKRR (in isoform c)"
FT /evidence="ECO:0000303|PubMed:9851916"
FT /id="VSP_051628"
FT VAR_SEQ 144..148
FT /note="DLKDQ -> QEKIV (in isoform b)"
FT /evidence="ECO:0000303|PubMed:9851916"
FT /id="VSP_051626"
FT VAR_SEQ 149..312
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000303|PubMed:9851916"
FT /id="VSP_051627"
FT VAR_SEQ 151..312
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000303|PubMed:9851916"
FT /id="VSP_051629"
SQ SEQUENCE 312 AA; 35042 MW; 457C9DB8537F1514 CRC64;
MAARIYIGRL TSRVSEKDIE HFFRGYGQIR DVLLKNGFGF VEFDDKRDAE DAVHDLNGKE
LGGERVILDY SKPRGGGGDR GGFGGGGRGG ARVSSYSGGG GGGRDRFDRY DRGPPRRESR
YGRPYSTRHR VVVENLSSRI SWQDLKDQVR RQGVEPTYAE AHKRPNEALL CFATPSDLKR
CIEKCDGMDL NGRKIKMIDD SQAGRSRSRS NSRSRSRSRS RDRRRSRSRS SSRSKSRSRS
PPKRSRRESK SKSRSRSRSR SADNRKSRSP SRSPKKVDRS PSPPRGSRSP SEKGSPRRSR
SASPMDNGDG DN
