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RSP4_CAEEL
ID   RSP4_CAEEL              Reviewed;         196 AA.
AC   Q09511; Q95QN7;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 154.
DE   RecName: Full=Probable splicing factor, arginine/serine-rich 4;
DE   AltName: Full=CeSC35;
DE   AltName: Full=RNA-binding protein srp-2;
GN   Name=rsp-4; Synonyms=srp-2; ORFNames=EEED8.7;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   IDENTIFICATION, AND FUNCTION.
RX   PubMed=10747030; DOI=10.1093/emboj/19.7.1625;
RA   Longman D., Johnstone I.L., Caceres J.F.;
RT   "Functional characterization of SR and SR-related genes in Caenorhabditis
RT   elegans.";
RL   EMBO J. 19:1625-1637(2000).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=10906451; DOI=10.1016/s0925-4773(00)00339-7;
RA   Kawano T., Fujita M., Sakamoto H.;
RT   "Unique and redundant functions of SR proteins, a conserved family of
RT   splicing factors, in Caenorhabditis elegans development.";
RL   Mech. Dev. 95:67-76(2000).
CC   -!- FUNCTION: May play a functionally redundant role in embryogenesis.
CC       {ECO:0000269|PubMed:10747030, ECO:0000269|PubMed:10906451}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10906451}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a;
CC         IsoId=Q09511-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=Q09511-2; Sequence=VSP_012275, VSP_012276;
CC   -!- PTM: Extensively phosphorylated on serine residues in the RS domain.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the splicing factor SR family. {ECO:0000305}.
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DR   EMBL; FO081042; CCD68734.1; -; Genomic_DNA.
DR   EMBL; FO081042; CCD68735.1; -; Genomic_DNA.
DR   PIR; T15917; T15917.
DR   RefSeq; NP_495013.1; NM_062612.4.
DR   RefSeq; NP_495014.1; NM_062613.1. [Q09511-2]
DR   AlphaFoldDB; Q09511; -.
DR   SMR; Q09511; -.
DR   BioGRID; 39259; 16.
DR   DIP; DIP-26638N; -.
DR   STRING; 6239.EEED8.7a; -.
DR   iPTMnet; Q09511; -.
DR   EPD; Q09511; -.
DR   PaxDb; Q09511; -.
DR   PeptideAtlas; Q09511; -.
DR   PRIDE; Q09511; -.
DR   EnsemblMetazoa; EEED8.7a.1; EEED8.7a.1; WBGene00004701. [Q09511-1]
DR   EnsemblMetazoa; EEED8.7b.1; EEED8.7b.1; WBGene00004701. [Q09511-2]
DR   EnsemblMetazoa; EEED8.7b.2; EEED8.7b.2; WBGene00004701. [Q09511-2]
DR   GeneID; 173915; -.
DR   UCSC; EEED8.7a; c. elegans. [Q09511-1]
DR   CTD; 173915; -.
DR   WormBase; EEED8.7a; CE01891; WBGene00004701; rsp-4. [Q09511-1]
DR   WormBase; EEED8.7b; CE27910; WBGene00004701; rsp-4. [Q09511-2]
DR   eggNOG; KOG4207; Eukaryota.
DR   GeneTree; ENSGT00940000154883; -.
DR   HOGENOM; CLU_012062_10_3_1; -.
DR   InParanoid; Q09511; -.
DR   OMA; PLIRCDV; -.
DR   OrthoDB; 1524134at2759; -.
DR   PRO; PR:Q09511; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00004701; Expressed in embryo and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; ISS:WormBase.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:WormBase.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:InterPro.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR034893; SRSF2-like.
DR   PANTHER; PTHR23147:SF145; PTHR23147:SF145; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Developmental protein; mRNA processing;
KW   mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; RNA-binding.
FT   CHAIN           1..196
FT                   /note="Probable splicing factor, arginine/serine-rich 4"
FT                   /id="PRO_0000081951"
FT   DOMAIN          19..97
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          91..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..110
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        111..143
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..183
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         116..126
FT                   /note="SRSPRRRSRSP -> TAAEPDVAELS (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_012275"
FT   VAR_SEQ         127..196
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_012276"
SQ   SEQUENCE   196 AA;  22588 MW;  61C047002F266DD5 CRC64;
     MSRGGGGDRR AAPDINGLTS LKIDNLSYQT TPNDLRRTFE RYGDIGDVHI PRDKYSRQSK
     GFGFVRFYER RDAEHALDRT DGKLVDGREL RVTLAKYDRP SDERGGRGGG GGRRRSRSPR
     RRSRSPRYSR SRSPRRSRSR TRSPPSRDRR DSPDRRDNSR SRSRSPPPRE DGSPKERRSR
     SRSASRSPSR SRSNSR
 
 
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