ID   RSP6_CAEEL              Reviewed;         179 AA.
AC   Q18409; Q8WSW0; Q8WSW1;
DT   21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 155.
DE   RecName: Full=Probable splicing factor, arginine/serine-rich 6;
DE   AltName: Full=CeSRp20;
DE   AltName: Full=RNA-binding protein srp-1;
GN   Name=rsp-6; Synonyms=srp-1 {ECO:0000303|PubMed:10906451};
GN   ORFNames=C33H5.12;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   IDENTIFICATION, AND FUNCTION.
RX   PubMed=10747030; DOI=10.1093/emboj/19.7.1625;
RA   Longman D., Johnstone I.L., Caceres J.F.;
RT   "Functional characterization of SR and SR-related genes in Caenorhabditis
RT   elegans.";
RL   EMBO J. 19:1625-1637(2000).
RN   [3] {ECO:0000305}
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=10906451; DOI=10.1016/s0925-4773(00)00339-7;
RA   Kawano T., Fujita M., Sakamoto H.;
RT   "Unique and redundant functions of SR proteins, a conserved family of
RT   splicing factors, in Caenorhabditis elegans development.";
RL   Mech. Dev. 95:67-76(2000).
CC   -!- FUNCTION: Plays a functionally redundant role in shifting germ cell
CC       sexual differentiation in hermaprodites. Required for the development
CC       of somatic gonad structures and for progression from larval stage to
CC       adulthood. {ECO:0000269|PubMed:10747030, ECO:0000269|PubMed:10906451}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10906451}.
CC   -!- PTM: Extensively phosphorylated on serine residues in the RS domain.
CC       {ECO:0000250|UniProtKB:Q9NEW6}.
CC   -!- MISCELLANEOUS: RNA-mediated interference (RNAi) of rsp-5 and rsp-6
CC       result in fertile animals that exhibit excessive sperm and delayed
CC       oocyte production, and sterile animals that develop morphological
CC       abnormalities of somatic gonads. Rsp-2/rsp-6 RNAi caused severe
CC       abnormalities in somatic gonad structures and in some cases animals
CC       were arrested or dead at the larval stage.
CC   -!- SIMILARITY: Belongs to the splicing factor SR family. {ECO:0000255}.
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DR   EMBL; FO080768; CCD66574.1; -; Genomic_DNA.
DR   PIR; T34145; T34145.
DR   RefSeq; NP_741446.1; NM_171383.3.
DR   AlphaFoldDB; Q18409; -.
DR   SMR; Q18409; -.
DR   BioGRID; 42684; 17.
DR   DIP; DIP-27100N; -.
DR   IntAct; Q18409; 3.
DR   STRING; 6239.C33H5.12a; -.
DR   iPTMnet; Q18409; -.
DR   EPD; Q18409; -.
DR   PaxDb; Q18409; -.
DR   PeptideAtlas; Q18409; -.
DR   EnsemblMetazoa; C33H5.12a.1; C33H5.12a.1; WBGene00004703.
DR   GeneID; 177566; -.
DR   KEGG; cel:CELE_C33H5.12; -.
DR   UCSC; C33H5.12a.1; c. elegans.
DR   CTD; 177566; -.
DR   WormBase; C33H5.12a; CE04155; WBGene00004703; rsp-6.
DR   eggNOG; KOG0107; Eukaryota.
DR   GeneTree; ENSGT00940000165794; -.
DR   HOGENOM; CLU_012062_20_5_1; -.
DR   InParanoid; Q18409; -.
DR   OMA; ASVWWEL; -.
DR   OrthoDB; 1533297at2759; -.
DR   Reactome; R-CEL-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR   Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR   Reactome; R-CEL-72165; mRNA Splicing - Minor Pathway.
DR   Reactome; R-CEL-72187; mRNA 3'-end processing.
DR   Reactome; R-CEL-73856; RNA Polymerase II Transcription Termination.
DR   PRO; PR:Q18409; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00004703; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; ISS:WormBase.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0008406; P:gonad development; IGI:UniProtKB.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:WormBase.
DR   GO; GO:0031554; P:regulation of DNA-templated transcription, termination; IGI:WormBase.
DR   GO; GO:0008380; P:RNA splicing; NAS:UniProtKB.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Differentiation; mRNA processing; mRNA splicing;
KW   Nucleus; Phosphoprotein; Reference proteome; RNA-binding;
KW   Sexual differentiation.
FT   CHAIN           1..179
FT                   /note="Probable splicing factor, arginine/serine-rich 6"
FT                   /id="PRO_0000081953"
FT   DOMAIN          3..76
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          75..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..162
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   179 AA;  20481 MW;  7E5E09ECE00C3E7E CRC64;
     MDAKVYVGGL PSDATSQELE EIFDRFGRIR KVWVARRPPG FAFVEYDDVR DAEDAVRALD
     GSRICGVRAR VELSTGQRRG GGGRGGGFGG RGGGGRDRSP YRGDRGRSRS RSRDRGRDRS
     RDRSRDRSRD RSRDRSRERS RERERTRSRS RSPQERDRSH SKSRSRSRSR SRSRSASPH