RSP7_CAEEL
ID RSP7_CAEEL Reviewed; 452 AA.
AC O01159; P90797; Q8STE7;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 3.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Probable splicing factor, arginine/serine-rich 7;
DE AltName: Full=p54;
GN Name=rsp-7; ORFNames=D2089.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1] {ECO:0000312|EMBL:CAA85414.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2 {ECO:0000312|EMBL:CAA85414.2};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=10747030; DOI=10.1093/emboj/19.7.1625;
RA Longman D., Johnstone I.L., Caceres J.F.;
RT "Functional characterization of SR and SR-related genes in Caenorhabditis
RT elegans.";
RL EMBO J. 19:1625-1637(2000).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000303|PubMed:9851916};
CC IsoId=O01159-1; Sequence=Displayed;
CC Name=b {ECO:0000303|PubMed:9851916};
CC IsoId=O01159-2; Sequence=VSP_051634, VSP_051635;
CC -!- PTM: Extensively phosphorylated on serine residues in the RS domain.
CC {ECO:0000250|UniProtKB:Q9NEW6}.
CC -!- SIMILARITY: Belongs to the splicing factor SR family. {ECO:0000255}.
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DR EMBL; Z36948; CAA85414.2; -; Genomic_DNA.
DR EMBL; Z49911; CAA85414.2; JOINED; Genomic_DNA.
DR EMBL; Z36948; CAD30436.1; -; Genomic_DNA.
DR EMBL; Z49911; CAD30436.1; JOINED; Genomic_DNA.
DR PIR; T20382; T20382.
DR RefSeq; NP_741039.1; NM_171033.4.
DR RefSeq; NP_741040.1; NM_171034.4.
DR AlphaFoldDB; O01159; -.
DR STRING; 6239.D2089.1a; -.
DR iPTMnet; O01159; -.
DR EPD; O01159; -.
DR PaxDb; O01159; -.
DR PeptideAtlas; O01159; -.
DR PRIDE; O01159; -.
DR EnsemblMetazoa; D2089.1a.1; D2089.1a.1; WBGene00004704. [O01159-1]
DR EnsemblMetazoa; D2089.1b.1; D2089.1b.1; WBGene00004704. [O01159-2]
DR EnsemblMetazoa; D2089.1b.2; D2089.1b.2; WBGene00004704. [O01159-2]
DR GeneID; 174646; -.
DR UCSC; D2089.1b.1; c. elegans. [O01159-1]
DR CTD; 174646; -.
DR WormBase; D2089.1a; CE03111; WBGene00004704; rsp-7. [O01159-1]
DR WormBase; D2089.1b; CE30507; WBGene00004704; rsp-7. [O01159-2]
DR eggNOG; KOG4676; Eukaryota.
DR GeneTree; ENSGT01030000235193; -.
DR HOGENOM; CLU_030029_1_0_1; -.
DR InParanoid; O01159; -.
DR OMA; QTSVIHA; -.
DR OrthoDB; 1342709at2759; -.
DR PhylomeDB; O01159; -.
DR Reactome; R-CEL-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-CEL-72187; mRNA 3'-end processing.
DR Reactome; R-CEL-73856; RNA Polymerase II Transcription Termination.
DR PRO; PR:O01159; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00004704; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:WormBase.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 2.
PE 3: Inferred from homology;
KW Alternative splicing; mRNA processing; mRNA splicing; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..452
FT /note="Probable splicing factor, arginine/serine-rich 7"
FT /id="PRO_0000081954"
FT DOMAIN 10..91
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 163..240
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 258..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..382
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..435
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 131..137
FT /note="LITVDPT -> FYWPLPK (in isoform b)"
FT /evidence="ECO:0000303|PubMed:9851916"
FT /id="VSP_051634"
FT VAR_SEQ 138..452
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000303|PubMed:9851916"
FT /id="VSP_051635"
SQ SEQUENCE 452 AA; 52679 MW; ACA3BDCE96FAEC90 CRC64;
MSGEEKEKVK ILHVANISTS ATRDHIYNMF NYLGKIQDLK VYPSEGNITA NTLLKTAFIK
FDDERCVEVA QHLTNTVVID CAIVCLPYPN PVIPDEESFF NSGGSTTAGQ RQLPPHVTNK
IQESDDGSAL LITVDPTLEQ LGLPAYPPLP ADTDSAKVEE IRRTVYVGNL PKGVDGNEVL
ELFNMYFGEV MYARMASGPD ALPCAYAYVE FSQQASVCNA LQNDGFEFKE RPLKIQHSRV
AIIKPQAKTD EQALGEIEEA IRMGRNGDDR DRRRSRSPRR RRSPSPRRRR DSRDRDRDRD
RDRRRSRDRR SRSRDRDRDR DRKRSRSRDR KRRSRSRDNK DRDRKRSRSR DRRRRSKSRD
RKRERSRSRS KDRKRDKKRS RSRSPEKRRD KEDRKTEKKE NENESSLREK LLEKKAARKD
SSDDEWEEKP TPTNGEVKNE EIGNGDVVMA SE
