ID   RSPH1_CYPCA             Reviewed;         218 AA.
AC   Q6VTH5;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Radial spoke head 1 homolog;
DE   AltName: Full=Meichroacidin homolog;
DE   AltName: Full=Meichroacidin-like sperm-specific axonemal protein;
DE   AltName: Full=Testis-specific gene A2-like protein;
GN   Name=rsph1; Synonyms=msap, tsga2;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, DEVELOPMENTAL STAGE, AND INTERACTION WITH SPT7.
RC   TISSUE=Sperm;
RX   PubMed=15215198; DOI=10.1095/biolreprod.104.030346;
RA   Ju T.-K., Huang F.-L.;
RT   "MSAP, the meichroacidin homolog of carp (Cyprinus carpio), differs from
RT   the rodent counterpart in germline expression and involves flagellar
RT   differentiation.";
RL   Biol. Reprod. 71:1419-1429(2004).
CC   -!- FUNCTION: May play an important role in male meiosis (By similarity).
CC       May be involved in flagellar differentiation during spermiogenesis.
CC       {ECO:0000250, ECO:0000269|PubMed:15215198}.
CC   -!- SUBUNIT: Interacts with septin SEPT7. {ECO:0000269|PubMed:15215198}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum basal body
CC       {ECO:0000269|PubMed:15215198}. Note=Localizes to the basal body and
CC       flagellum of mature spermatozoa.
CC   -!- TISSUE SPECIFICITY: Testis-specific. {ECO:0000269|PubMed:15215198}.
CC   -!- DEVELOPMENTAL STAGE: Expressed during late spermiogenesis and
CC       accumulates in mature spermatozoa. {ECO:0000269|PubMed:15215198}.
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DR   EMBL; AY327474; AAQ95992.1; -; mRNA.
DR   AlphaFoldDB; Q6VTH5; -.
DR   SMR; Q6VTH5; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR003409; MORN.
DR   Pfam; PF02493; MORN; 6.
DR   SMART; SM00698; MORN; 6.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; Developmental protein;
KW   Differentiation; Flagellum; Meiosis; Reference proteome; Repeat;
KW   Spermatogenesis.
FT   CHAIN           1..218
FT                   /note="Radial spoke head 1 homolog"
FT                   /id="PRO_0000065661"
FT   REPEAT          19..42
FT                   /note="MORN 1"
FT   REPEAT          43..65
FT                   /note="MORN 2"
FT   REPEAT          66..88
FT                   /note="MORN 3"
FT   REPEAT          89..111
FT                   /note="MORN 4"
FT   REPEAT          112..134
FT                   /note="MORN 5"
FT   REPEAT          158..180
FT                   /note="MORN 6"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..35
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   218 AA;  24566 MW;  9074A2F972F48D66 CRC64;
     MSDAGTEEFD EEQGSLGEYE GDRNEAGERH GQGKAVLPRG DTYQGAYENG KRCGQGTYKF
     KNGARYTGEW YMNLKHGQGV LYYPDGSKYE GSWVDDQRQG HGVYTYPNGD TYDGEWLHHQ
     RHGQGTYTHQ ETGSQYRGTW VVGNMESTGE LIQLNHRYHG NFVNNNPSGP GKYVFDIGCE
     QHGEYFQLEP DKGEAEEDET LISTTLKWKP KAVTGLSV