ID   RSPH3_BOVIN             Reviewed;         606 AA.
AC   A8E4N3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Radial spoke head protein 3 homolog;
DE   AltName: Full=A-kinase anchor protein RSPH3;
DE   AltName: Full=Radial spoke head-like protein 2;
GN   Name=RSPH3; Synonyms=RSHL2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a protein kinase A-anchoring protein that
CC       scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a
CC       point of convergence for MAPK and PKA signaling in cilia (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with phosphorylated MAPK1. Interacts with MEK1.
CC       Interacts with PKA regulatory subunits PRKAR1A and PRKAR1B (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:P12759}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q86UC2}.
CC   -!- SIMILARITY: Belongs to the flagellar radial spoke RSP3 family.
CC       {ECO:0000305}.
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DR   EMBL; BC149859; AAI49860.1; -; mRNA.
DR   RefSeq; NP_001103269.1; NM_001109799.1.
DR   RefSeq; XP_010807026.1; XM_010808724.2.
DR   AlphaFoldDB; A8E4N3; -.
DR   SMR; A8E4N3; -.
DR   STRING; 9913.ENSBTAP00000007814; -.
DR   PaxDb; A8E4N3; -.
DR   PRIDE; A8E4N3; -.
DR   Ensembl; ENSBTAT00000007814; ENSBTAP00000007814; ENSBTAG00000005955.
DR   GeneID; 533135; -.
DR   KEGG; bta:533135; -.
DR   CTD; 83861; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005955; -.
DR   VGNC; VGNC:34184; RSPH3.
DR   eggNOG; ENOG502QQSZ; Eukaryota.
DR   GeneTree; ENSGT00390000004172; -.
DR   HOGENOM; CLU_036980_4_0_1; -.
DR   InParanoid; A8E4N3; -.
DR   OMA; WHYVHLS; -.
DR   OrthoDB; 955313at2759; -.
DR   TreeFam; TF324184; -.
DR   Proteomes; UP000009136; Chromosome 9.
DR   Bgee; ENSBTAG00000005955; Expressed in olfactory segment of nasal mucosa and 100 other tissues.
DR   GO; GO:0005929; C:cilium; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   InterPro; IPR009290; Radial_spoke_3.
DR   PANTHER; PTHR21648; PTHR21648; 1.
DR   Pfam; PF06098; Radial_spoke_3; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Coiled coil; Cytoplasm; Cytoskeleton; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..606
FT                   /note="Radial spoke head protein 3 homolog"
FT                   /id="PRO_0000313740"
FT   REGION          1..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          520..606
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          393..429
FT                   /evidence="ECO:0000255"
FT   COILED          572..604
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        547..561
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        564..606
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         331
FT                   /note="Phosphothreonine; by MAPK1"
FT                   /evidence="ECO:0000250|UniProtKB:Q86UC2"
SQ   SEQUENCE   606 AA;  68700 MW;  9C9B149AF7D817C0 CRC64;
     MARSEARRQA REKRPRAVPE ERALRERRQP RPRREPLESG AGDHRRPPQA SAGAAGHASF
     MRRLVDQEDA GGQSQEPEVL GRTGNLPRKP ASRNSPEAPP LDGTLGCWAT GAGAAGGFGG
     AQNRACVAPT SCPGNLPARP LPFLPPLLAS RNPCPWHYVH LSGSHDTLVP TCFEAKLHQK
     GSGPTPSATS TLAERASPAM ATYTYTSRPR ALPCQRRRYR DDLMQQPEEP VHYGNIMYDR
     RVIRGNTYAL QSVPLPGQPD PVEIQRQQQA RRRAFARKQA QEQLRPRTPE PVEGRKHVDV
     QTELYLEEIA DRIVEVDMEC QTDAFLDKPP TPLFIPAKTG KDVATEILEG ELFDFDLEVK
     PMLEVLVGKT IEQSLLEVME EEELANLRAS QYAYEELRNI ELAEVQRLEE QERRHREEKE
     RRKQQQWQVV HKHNETSQKI AARAFAQRYL ADLLPSVFDS LRDGGYFYDP VERDIEIGFL
     PWLMNEVDKT MESSMVGRTV LDMLIREVVE RRLNLYEQKE GRHASVRPEN GLGGPGGTRE
     PLVGFESQDQ GASQAQRPLP DRDSLQRTPY DARYAERVSS QERRLAEEND ELTEMRKSSK
     REELSQ