ID   RSPRY_PONAB             Reviewed;         576 AA.
AC   Q5R881;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=RING finger and SPRY domain-containing protein 1;
DE   Flags: Precursor;
GN   Name=RSPRY1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR   EMBL; CR859873; CAH92029.1; -; mRNA.
DR   RefSeq; NP_001126179.1; NM_001132707.1.
DR   RefSeq; XP_009249028.1; XM_009250753.1.
DR   RefSeq; XP_009249029.1; XM_009250754.1.
DR   AlphaFoldDB; Q5R881; -.
DR   SMR; Q5R881; -.
DR   STRING; 9601.ENSPPYP00000008340; -.
DR   Ensembl; ENSPPYT00000008681; ENSPPYP00000008340; ENSPPYG00000007383.
DR   GeneID; 100173142; -.
DR   KEGG; pon:100173142; -.
DR   CTD; 89970; -.
DR   eggNOG; KOG2242; Eukaryota.
DR   GeneTree; ENSGT00940000157894; -.
DR   HOGENOM; CLU_026400_0_0_1; -.
DR   InParanoid; Q5R881; -.
DR   OMA; DSGIWYY; -.
DR   OrthoDB; 1005747at2759; -.
DR   TreeFam; TF313546; -.
DR   Proteomes; UP000001595; Chromosome 16.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   CDD; cd12883; SPRY_RING; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR045129; RNF123/RSPRY1-like.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035774; SPRY_RSPRY1.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13363; PTHR13363; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Metal-binding; Phosphoprotein; Reference proteome; Secreted;
KW   Signal; Zinc; Zinc-finger.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..576
FT                   /note="RING finger and SPRY domain-containing protein 1"
FT                   /id="PRO_0000278789"
FT   DOMAIN          300..483
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT   ZN_FING         527..562
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          50..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..73
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         50
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BVR6"
FT   CARBOHYD        314
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   576 AA;  64210 MW;  8598E438D4F7603E CRC64;
     MIVFGWAVFL ASRSLGQGLL LTLEEHIAHF LGTGGATTTM GNSCICRDDS GTDDSVDTQQ
     QQAENSAVPT ADTRSQPRDP VRPPRRGRGP HEPRRKKQNV DGLVLDTLAV IRTLVDNDQE
     PPYSMITLHE MAETDEGWLD VVQSLIRVIP LEDPLGPAVI TLLLDECPLP TKDALQKLTE
     ILNLNGEVAC QDSSHPAKHR NTSAVLGCLA EKLAGPASIG LLSPGILEYL LQCLKLQSHP
     TVMLFALIAL EKFAQTSENK LTISESSISD RLVTLESWAN DPDYLKRQVG FCAQWSLDNL
     FLKEGRQLTY EKVNLSSIRA MLNSNDVSEY LKISPHGLEA RCDASSFESV RCTFCVDAGV
     WYYEVTVVTS GVMQIGWATR DSKFLNHEGY GIGDDEYSCA YDGCRQLIWY NARSKPHIHP
     CWKEGDTVGF LLDLNEKQMI FFLNGNQLPP EKQVFSSTVS GFFAAASFMS YQQCEFNFGA
     KPFKYPPSMK FSTFNDYAFL TAEEKIILPR HRRLALLKQV SIRENCCSLC CDEVADTQLK
     PCGHSDLCMD CALQLETCPL CRKEIVSRIR QISHIS