ID   RSPR_ECOLI              Reviewed;         228 AA.
AC   P0ACM2; P77577; Q83L25;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=HTH-type transcriptional repressor RspR;
GN   Name=rspR; Synonyms=ydfH; OrderedLocusNames=b1540, JW1533;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA   Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA   Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA   Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA   Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA   Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA   Wada C., Yamamoto Y., Horiuchi T.;
RT   "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 28.0-40.1 min region on the linkage map.";
RL   DNA Res. 3:363-377(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   FUNCTION, AND DNA-BINDING.
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=22972332; DOI=10.1271/bbb.120273;
RA   Sakihama Y., Mizoguchi H., Oshima T., Ogasawara N.;
RT   "YdfH identified as a repressor of rspA by the use of reduced genome
RT   Escherichia coli MGF-01.";
RL   Biosci. Biotechnol. Biochem. 76:1688-1693(2012).
CC   -!- FUNCTION: Repressor of the rspAB operon. Acts by binding directly to
CC       the upstream region of rspA. {ECO:0000269|PubMed:22972332}.
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DR   EMBL; U00096; AAC74613.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA15242.1; -; Genomic_DNA.
DR   PIR; G64908; G64908.
DR   RefSeq; NP_416058.1; NC_000913.3.
DR   RefSeq; WP_000215549.1; NZ_STEB01000003.1.
DR   AlphaFoldDB; P0ACM2; -.
DR   SMR; P0ACM2; -.
DR   BioGRID; 4261737; 22.
DR   IntAct; P0ACM2; 2.
DR   STRING; 511145.b1540; -.
DR   jPOST; P0ACM2; -.
DR   PaxDb; P0ACM2; -.
DR   PRIDE; P0ACM2; -.
DR   EnsemblBacteria; AAC74613; AAC74613; b1540.
DR   EnsemblBacteria; BAA15242; BAA15242; BAA15242.
DR   GeneID; 66674599; -.
DR   GeneID; 946087; -.
DR   KEGG; ecj:JW1533; -.
DR   KEGG; eco:b1540; -.
DR   PATRIC; fig|511145.12.peg.1610; -.
DR   EchoBASE; EB3581; -.
DR   eggNOG; COG1802; Bacteria.
DR   HOGENOM; CLU_017584_5_2_6; -.
DR   InParanoid; P0ACM2; -.
DR   OMA; AWDTVEN; -.
DR   PhylomeDB; P0ACM2; -.
DR   BioCyc; EcoCyc:G6814-MON; -.
DR   PRO; PR:P0ACM2; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IDA:EcoCyc.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   InterPro; IPR011711; GntR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF07729; FCD; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00895; FCD; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..228
FT                   /note="HTH-type transcriptional repressor RspR"
FT                   /id="PRO_0000050672"
FT   DOMAIN          11..78
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        38..57
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   228 AA;  26565 MW;  8CFF8EB3BCF9AF84 CRC64;
     MTVETQLNPT QPVNQQIYRI LRRDIVHCLI APGTPLSEKE VSVRFNVSRQ PVREAFIKLA
     ENGLIQIRPQ RGSYVNKISM AQVRNGSFIR QAIECAVARR AASMITESQC YQLEQNLHQQ
     RIAIERKQLD DFFELDDNFH QLLTQIADCQ LAWDTIENLK ATVDRVRYMS FDHVSPPEML
     LRQHLDIFSA LQKRDGDAVE RAMTQHLQEI SESVRQIRQE NSDWFSEE