ID   RSRC1_BOVIN             Reviewed;         334 AA.
AC   Q2T9Y0;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Serine/Arginine-related protein 53;
DE            Short=SRrp53;
DE   AltName: Full=Arginine/serine-rich coiled-coil protein 1;
GN   Name=RSRC1; Synonyms=SRRP53;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in pre-mRNA splicing. Involved both in the
CC       constitutive and regulation of pre-mRNA splicing. May have a role in
CC       the recognition of the 3' splice site during the second step of
CC       splicing (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts (via Arg/Ser-rich domain) with LUC7L3, RBM39 and
CC       RSF1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus speckle
CC       {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles between the
CC       nucleus and cytoplasm. {ECO:0000250}.
CC   -!- PTM: Phosphorylated. {ECO:0000250|UniProtKB:Q9DBU6}.
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DR   EMBL; BC111215; AAI11216.1; -; mRNA.
DR   RefSeq; NP_001068872.1; NM_001075404.1.
DR   AlphaFoldDB; Q2T9Y0; -.
DR   SMR; Q2T9Y0; -.
DR   STRING; 9913.ENSBTAP00000042183; -.
DR   PaxDb; Q2T9Y0; -.
DR   PRIDE; Q2T9Y0; -.
DR   Ensembl; ENSBTAT00000044707; ENSBTAP00000042183; ENSBTAG00000031561.
DR   GeneID; 509437; -.
DR   KEGG; bta:509437; -.
DR   CTD; 51319; -.
DR   VEuPathDB; HostDB:ENSBTAG00000031561; -.
DR   VGNC; VGNC:53602; RSRC1.
DR   eggNOG; KOG3406; Eukaryota.
DR   GeneTree; ENSGT00730000111251; -.
DR   HOGENOM; CLU_072086_0_0_1; -.
DR   InParanoid; Q2T9Y0; -.
DR   OMA; VIFHPNF; -.
DR   OrthoDB; 1367755at2759; -.
DR   TreeFam; TF336021; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000031561; Expressed in semen and 106 other tissues.
DR   ExpressionAtlas; Q2T9Y0; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000380; P:alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   GO; GO:0006913; P:nucleocytoplasmic transport; ISS:UniProtKB.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:Ensembl.
DR   GO; GO:0046677; P:response to antibiotic; IEA:Ensembl.
DR   InterPro; IPR034604; SRRP53.
DR   PANTHER; PTHR31968; PTHR31968; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..334
FT                   /note="Serine/Arginine-related protein 53"
FT                   /id="PRO_0000401193"
FT   REGION          1..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          201..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          259..284
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          180..225
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        47..61
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..135
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..165
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   334 AA;  38710 MW;  1C4E104CE410FC25 CRC64;
     MGRRSSDTEE ESRSKRKKKH RRRSSSSSSS DSRTYSRKKG GRRSRSKSRS WSRDLQPRSH
     SYDRRRRHRS SSSSSYGSRR KRSQSRSRGR GKSYRVQRSR SKSRTRRSRS RPRPRSHSRS
     SERSSHRRTR SRSRDRERRK GRDKEKREKE KDKGKDKELH NIKRGESGNI KAGLEHLPPA
     EQAKARLQLV LEAAAKADEA LKAKERNEEE AKRRKEEDQT TLVEQVKRVK EIEAIESDSF
     VQQTFRSSKE IKKAVEASEV KHAATTSGPA SVVADPPSNE KEIDPSNIPT AIKYQDDNSL
     AHPNLFIEKA DAEEKWFKRL IALRQERLMG SPVA