RSRP1_HUMAN
ID RSRP1_HUMAN Reviewed; 290 AA.
AC Q9BUV0; A8K917; Q49AA4; Q5TH71; Q9GZP6;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Arginine/serine-rich protein 1;
GN Name=RSRP1; Synonyms=C1orf63; ORFNames=HT033, NPD014;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Embryo, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Pituitary;
RA Song H., Gao G., Peng Y., Ren S., Chen Z., Han Z.;
RT "A novel gene expressed in the human pituitary gland.";
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Hypothalamus;
RA Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.;
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT
RP GLY-239.
RC TISSUE=Lung, Skin, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9BUV0; Q9UK58: CCNL1; NbExp=3; IntAct=EBI-745604, EBI-2836773;
CC Q9BUV0; P49760: CLK2; NbExp=13; IntAct=EBI-745604, EBI-750020;
CC Q9BUV0; P49761: CLK3; NbExp=11; IntAct=EBI-745604, EBI-745579;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9BUV0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BUV0-2; Sequence=VSP_027305;
CC Name=3;
CC IsoId=Q9BUV0-3; Sequence=VSP_027306, VSP_027307;
CC -!- MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the RSRP family. {ECO:0000305}.
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DR EMBL; AK027318; BAB55038.1; -; mRNA.
DR EMBL; AK292532; BAF85221.1; -; mRNA.
DR EMBL; AF247168; AAG44543.1; -; mRNA.
DR EMBL; AF267856; AAG44725.1; -; mRNA.
DR EMBL; AL031432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471134; EAW95157.1; -; Genomic_DNA.
DR EMBL; BC001892; AAH01892.1; -; mRNA.
DR EMBL; BC041843; AAH41843.1; -; mRNA.
DR EMBL; BC065040; AAH65040.1; -; mRNA.
DR CCDS; CCDS260.1; -. [Q9BUV0-1]
DR RefSeq; NP_001308701.1; NM_001321772.1. [Q9BUV0-1]
DR RefSeq; NP_064713.3; NM_020317.4. [Q9BUV0-1]
DR RefSeq; XP_011540099.1; XM_011541797.1. [Q9BUV0-1]
DR AlphaFoldDB; Q9BUV0; -.
DR SMR; Q9BUV0; -.
DR BioGRID; 121332; 27.
DR IntAct; Q9BUV0; 21.
DR MINT; Q9BUV0; -.
DR STRING; 9606.ENSP00000243189; -.
DR GlyGen; Q9BUV0; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9BUV0; -.
DR PhosphoSitePlus; Q9BUV0; -.
DR BioMuta; RSRP1; -.
DR DMDM; 156630464; -.
DR MassIVE; Q9BUV0; -.
DR MaxQB; Q9BUV0; -.
DR PaxDb; Q9BUV0; -.
DR PeptideAtlas; Q9BUV0; -.
DR PRIDE; Q9BUV0; -.
DR ProteomicsDB; 79133; -. [Q9BUV0-1]
DR ProteomicsDB; 79134; -. [Q9BUV0-2]
DR ProteomicsDB; 79135; -. [Q9BUV0-3]
DR Antibodypedia; 30373; 71 antibodies from 15 providers.
DR DNASU; 57035; -.
DR Ensembl; ENST00000243189.12; ENSP00000243189.7; ENSG00000117616.18. [Q9BUV0-1]
DR Ensembl; ENST00000431849.3; ENSP00000391510.3; ENSG00000117616.18. [Q9BUV0-2]
DR Ensembl; ENST00000473314.6; ENSP00000457582.1; ENSG00000117616.18. [Q9BUV0-3]
DR GeneID; 57035; -.
DR KEGG; hsa:57035; -.
DR MANE-Select; ENST00000243189.12; ENSP00000243189.7; NM_020317.5; NP_064713.3.
DR UCSC; uc001bjw.4; human. [Q9BUV0-1]
DR CTD; 57035; -.
DR DisGeNET; 57035; -.
DR GeneCards; RSRP1; -.
DR HGNC; HGNC:25234; RSRP1.
DR HPA; ENSG00000117616; Low tissue specificity.
DR neXtProt; NX_Q9BUV0; -.
DR OpenTargets; ENSG00000117616; -.
DR PharmGKB; PA142672513; -.
DR VEuPathDB; HostDB:ENSG00000117616; -.
DR eggNOG; ENOG502S6J6; Eukaryota.
DR GeneTree; ENSGT00730000111390; -.
DR HOGENOM; CLU_058639_0_0_1; -.
DR InParanoid; Q9BUV0; -.
DR OMA; KETNHGT; -.
DR PhylomeDB; Q9BUV0; -.
DR TreeFam; TF338669; -.
DR PathwayCommons; Q9BUV0; -.
DR SignaLink; Q9BUV0; -.
DR BioGRID-ORCS; 57035; 15 hits in 1074 CRISPR screens.
DR ChiTaRS; RSRP1; human.
DR GenomeRNAi; 57035; -.
DR Pharos; Q9BUV0; Tdark.
DR PRO; PR:Q9BUV0; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9BUV0; protein.
DR Bgee; ENSG00000117616; Expressed in germinal epithelium of ovary and 206 other tissues.
DR ExpressionAtlas; Q9BUV0; baseline and differential.
DR Genevisible; Q9BUV0; HS.
DR InterPro; IPR029656; RSRP1.
DR PANTHER; PTHR47622; PTHR47622; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Methylation; Phosphoprotein; Reference proteome.
FT CHAIN 1..290
FT /note="Arginine/serine-rich protein 1"
FT /id="PRO_0000297617"
FT REGION 1..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..99
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..123
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 12
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3UC65"
FT MOD_RES 135
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q3UC65"
FT MOD_RES 274
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5U2S0"
FT VAR_SEQ 225..290
FT /note="LSEKVTEDGTRNPNEKPTQQRSIAFSSNNSVAKPIQKSAKAATEEASSRSPK
FT IDQKKSPYGLWIPI -> VSILGLSEQNFQKANCQI (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.2,
FT ECO:0000303|Ref.3"
FT /id="VSP_027305"
FT VAR_SEQ 225..226
FT /note="LS -> KS (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027306"
FT VAR_SEQ 227..290
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027307"
FT VARIANT 147
FT /note="Y -> H (in dbSNP:rs34619962)"
FT /id="VAR_034655"
FT VARIANT 239
FT /note="E -> G (in dbSNP:rs1043879)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_034656"
SQ SEQUENCE 290 AA; 33613 MW; E729EA9895672216 CRC64;
MSNYVNDMWP GSPQEKDSPS TSRSGGSSRL SSRSRSRSFS RSSRSHSRVS SRFSSRSRRS
KSRSRSRRRH QRKYRRYSRS YSRSRSRSRS RRYRERRYGF TRRYYRSPSR YRSRSRSRSR
SRGRSYCGRA YAIARGQRYY GFGRTVYPEE HSRWRDRSRT RSRSRTPFRL SEKDRMELLE
IAKTNAAKAL GTTNIDLPAS LRTVPSAKET SRGIGVSSNG AKPELSEKVT EDGTRNPNEK
PTQQRSIAFS SNNSVAKPIQ KSAKAATEEA SSRSPKIDQK KSPYGLWIPI
