RSRP1_MOUSE
ID RSRP1_MOUSE Reviewed; 298 AA.
AC Q3UC65; Q80Y97; Q9CSN6; Q9D194; Q9JJF1;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Arginine/serine-rich protein 1;
GN Name=Rsrp1; Synonyms=D4Wsu53e; ORFNames=MNCb-0169;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Bone marrow macrophage, Embryo, Embryonic head, Testis, Thymus, and
RC Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-145, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q3UC65-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3UC65-2; Sequence=VSP_027308;
CC Name=3;
CC IsoId=Q3UC65-3; Sequence=VSP_027309, VSP_027310;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the RSRP family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-6 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AB041555; BAA95040.1; -; mRNA.
DR EMBL; AK003799; BAB23002.1; -; mRNA.
DR EMBL; AK012363; BAB28190.3; -; mRNA.
DR EMBL; AK028145; BAC25773.1; -; mRNA.
DR EMBL; AK029529; BAC26498.1; -; mRNA.
DR EMBL; AK150024; BAE29249.1; -; mRNA.
DR EMBL; AK150665; BAE29749.1; -; mRNA.
DR EMBL; AK152736; BAE31456.1; -; mRNA.
DR EMBL; AK160993; BAE36138.1; -; mRNA.
DR EMBL; AK169598; BAE41249.1; -; mRNA.
DR EMBL; AK169760; BAE41350.1; -; mRNA.
DR EMBL; AL611963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC043057; AAH43057.1; -; mRNA.
DR EMBL; BC046231; AAH46231.2; -; mRNA.
DR EMBL; BC054728; AAH54728.1; -; mRNA.
DR EMBL; BC056986; AAH56986.1; -; mRNA.
DR CCDS; CCDS51328.1; -. [Q3UC65-1]
DR RefSeq; NP_076154.3; NM_023665.3. [Q3UC65-1]
DR AlphaFoldDB; Q3UC65; -.
DR SMR; Q3UC65; -.
DR IntAct; Q3UC65; 1.
DR MINT; Q3UC65; -.
DR STRING; 10090.ENSMUSP00000077226; -.
DR iPTMnet; Q3UC65; -.
DR PhosphoSitePlus; Q3UC65; -.
DR EPD; Q3UC65; -.
DR jPOST; Q3UC65; -.
DR MaxQB; Q3UC65; -.
DR PaxDb; Q3UC65; -.
DR PeptideAtlas; Q3UC65; -.
DR PRIDE; Q3UC65; -.
DR ProteomicsDB; 256792; -. [Q3UC65-1]
DR ProteomicsDB; 256793; -. [Q3UC65-2]
DR ProteomicsDB; 256794; -. [Q3UC65-3]
DR Antibodypedia; 30373; 71 antibodies from 15 providers.
DR DNASU; 27981; -.
DR Ensembl; ENSMUST00000078084; ENSMUSP00000077226; ENSMUSG00000037266. [Q3UC65-1]
DR GeneID; 27981; -.
DR KEGG; mmu:27981; -.
DR UCSC; uc008vfx.1; mouse. [Q3UC65-1]
DR UCSC; uc008vfz.1; mouse. [Q3UC65-3]
DR CTD; 57035; -.
DR MGI; MGI:106498; Rsrp1.
DR VEuPathDB; HostDB:ENSMUSG00000037266; -.
DR eggNOG; ENOG502S6J6; Eukaryota.
DR GeneTree; ENSGT00730000111390; -.
DR HOGENOM; CLU_058639_0_0_1; -.
DR InParanoid; Q3UC65; -.
DR OMA; KETNHGT; -.
DR OrthoDB; 1527220at2759; -.
DR TreeFam; TF338669; -.
DR BioGRID-ORCS; 27981; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Rsrp1; mouse.
DR PRO; PR:Q3UC65; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q3UC65; protein.
DR Bgee; ENSMUSG00000037266; Expressed in lymph node and 258 other tissues.
DR Genevisible; Q3UC65; MM.
DR InterPro; IPR029656; RSRP1.
DR PANTHER; PTHR47622; PTHR47622; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Methylation; Phosphoprotein; Reference proteome.
FT CHAIN 1..298
FT /note="Arginine/serine-rich protein 1"
FT /id="PRO_0000297619"
FT REGION 1..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..58
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..102
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..134
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 17
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 145
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 282
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5U2S0"
FT VAR_SEQ 233..298
FT /note="HSEKQTEDATKNTSEKSSTQRNIAFSSNNSVAKPLQKTTKAAVEEKSSGSPK
FT IDKKKSPYGLWIPV -> VSAFRKLLPAFITLCQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_027308"
FT VAR_SEQ 233..234
FT /note="HS -> KS (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072, ECO:0000303|Ref.1"
FT /id="VSP_027309"
FT VAR_SEQ 235..298
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072, ECO:0000303|Ref.1"
FT /id="VSP_027310"
FT CONFLICT 158
FT /note="P -> T (in Ref. 2; BAB28190)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 298 AA; 34539 MW; 5B44F3F9AA4E6CDC CRC64;
MSSAAMSKYV NDMWPGSPQE KASPSTSGSG RSSRLSSRSR SRSSSRSSRR DSRSSSRSSS
RSHSRPRRSR RSRSRSRRRH QRKYRRYSRS YSRSRSRSRS HRYHRDSRYE RPRRYYKSPS
PYRSRSRSRS RGRSQHRWSY YAITRGRRYY GFGRTVYPED RPRWRERSRT RSRSRSRTPF
RLSEKDRMEL LEIAKANAAK ALGTANFDLP ASLRAKEASQ GTAVSSSGPK VEHSEKQTED
ATKNTSEKSS TQRNIAFSSN NSVAKPLQKT TKAAVEEKSS GSPKIDKKKS PYGLWIPV
