RSRP1_RAT
ID RSRP1_RAT Reviewed; 300 AA.
AC Q5U2S0;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Arginine/serine-rich protein 1;
GN Name=Rsrp1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17 AND SER-284, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5U2S0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5U2S0-2; Sequence=VSP_027311;
CC -!- SIMILARITY: Belongs to the RSRP family. {ECO:0000305}.
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DR EMBL; AABR03041758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC085888; AAH85888.1; -; mRNA.
DR RefSeq; NP_001014215.2; NM_001014193.2. [Q5U2S0-1]
DR AlphaFoldDB; Q5U2S0; -.
DR SMR; Q5U2S0; -.
DR STRING; 10116.ENSRNOP00000023289; -.
DR iPTMnet; Q5U2S0; -.
DR PhosphoSitePlus; Q5U2S0; -.
DR PaxDb; Q5U2S0; -.
DR Ensembl; ENSRNOT00000023289; ENSRNOP00000023289; ENSRNOG00000017309. [Q5U2S0-1]
DR Ensembl; ENSRNOT00000082184; ENSRNOP00000072995; ENSRNOG00000017309. [Q5U2S0-2]
DR GeneID; 362626; -.
DR KEGG; rno:362626; -.
DR UCSC; RGD:1359529; rat. [Q5U2S0-1]
DR CTD; 57035; -.
DR RGD; 1359529; Rsrp1.
DR eggNOG; ENOG502S6J6; Eukaryota.
DR GeneTree; ENSGT00940000174265; -.
DR HOGENOM; CLU_058639_0_0_1; -.
DR InParanoid; Q5U2S0; -.
DR OMA; KETNHGT; -.
DR OrthoDB; 1527220at2759; -.
DR TreeFam; TF338669; -.
DR PRO; PR:Q5U2S0; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000017309; Expressed in thymus and 20 other tissues.
DR Genevisible; Q5U2S0; RN.
DR InterPro; IPR029656; RSRP1.
DR PANTHER; PTHR47622; PTHR47622; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Methylation; Phosphoprotein; Reference proteome.
FT CHAIN 1..300
FT /note="Arginine/serine-rich protein 1"
FT /id="PRO_0000297621"
FT REGION 1..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..104
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..142
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 17
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 147
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q3UC65"
FT MOD_RES 284
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT VAR_SEQ 234..300
FT /note="HSEKQTEVGTKNASEKSAAAQRNIAFSSNNSVAKPLEKTTKAAVEETSSGSP
FT KIDKKKSPYGLWIPV -> VSPFRKLLPAVSTLCSVP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027311"
SQ SEQUENCE 300 AA; 34516 MW; 1DBB1E2756D4EFE3 CRC64;
MSSAAVSKYV NDMWPGSPQE KASPSTSGSG RSSRLSSRSR SRSSSRSSRP HSRSSSRSSS
RSHSRPRRSR RSRSRSRSRR RHQRKYRRYS RSYSRSRSRS RGHRYYRDSR YEQPRRYYQS
PSPYRSRSRS RSRGRSHHRR SYYAITRGRR YYGFGRTVYP EDRPRWRERS RTRSRSRSRT
PFRLSEKDRM ELLEIAKANA AKALGTANFD LPASLRAKEA SQGAVSCSGP KTEHSEKQTE
VGTKNASEKS AAAQRNIAFS SNNSVAKPLE KTTKAAVEET SSGSPKIDKK KSPYGLWIPV
