RSSA_LEIIN
ID RSSA_LEIIN Reviewed; 246 AA.
AC A4IDS4;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=40S ribosomal protein SA {ECO:0000255|HAMAP-Rule:MF_03015};
GN ORFNames=LinJ36.5570, LinJ_36_5240;
GN and
GN ORFNames=LinJ36.5680, LinJ_36_5350;
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5;
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Sqaures R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
CC -!- FUNCTION: Required for the assembly and/or stability of the 40S
CC ribosomal subunit. Required for the processing of the 20S rRNA-
CC precursor to mature 18S rRNA in a late step of the maturation of 40S
CC ribosomal subunits. {ECO:0000255|HAMAP-Rule:MF_03015}.
CC -!- SUBUNIT: Component of the small ribosomal subunit. Mature ribosomes
CC consist of a small (40S) and a large (60S) subunit. The 40S subunit
CC contains about 33 different proteins and 1 molecule of RNA (18S). The
CC 60S subunit contains about 49 different proteins and 3 molecules of RNA
CC (25S, 5.8S and 5S). Interacts with ribosomal protein S21.
CC {ECO:0000255|HAMAP-Rule:MF_03015}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03015}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS2 family.
CC {ECO:0000255|HAMAP-Rule:MF_03015}.
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DR EMBL; FR796468; CAM73007.1; -; Genomic_DNA.
DR EMBL; FR796468; CAM73018.1; -; Genomic_DNA.
DR RefSeq; XP_001469893.1; XM_001469856.1.
DR RefSeq; XP_001469903.1; XM_001469866.1.
DR PDB; 6AZ1; EM; 2.70 A; B=1-246.
DR PDBsum; 6AZ1; -.
DR AlphaFoldDB; A4IDS4; -.
DR SMR; A4IDS4; -.
DR STRING; 5671.XP_001469893.1; -.
DR GeneID; 5073999; -.
DR GeneID; 5074010; -.
DR KEGG; lif:LINJ_36_5240; -.
DR KEGG; lif:LINJ_36_5350; -.
DR VEuPathDB; TriTrypDB:LINF_360060700; -.
DR eggNOG; KOG0830; Eukaryota.
DR InParanoid; A4IDS4; -.
DR OMA; ENKMKRY; -.
DR Proteomes; UP000008153; Chromosome 36.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:UniProtKB-UniRule.
DR GO; GO:0000028; P:ribosomal small subunit assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR CDD; cd01425; RPS2; 1.
DR HAMAP; MF_03015; Ribosomal_S2_euk; 1.
DR InterPro; IPR001865; Ribosomal_S2.
DR InterPro; IPR018130; Ribosomal_S2_CS.
DR InterPro; IPR027498; Ribosomal_S2_euk.
DR InterPro; IPR005707; Ribosomal_S2_euk/arc.
DR InterPro; IPR023591; Ribosomal_S2_flav_dom_sf.
DR PANTHER; PTHR11489; PTHR11489; 1.
DR Pfam; PF00318; Ribosomal_S2; 1.
DR PRINTS; PR00395; RIBOSOMALS2.
DR SUPFAM; SSF52313; SSF52313; 1.
DR TIGRFAMs; TIGR01012; uS2_euk_arch; 1.
DR PROSITE; PS00963; RIBOSOMAL_S2_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT CHAIN 1..246
FT /note="40S ribosomal protein SA"
FT /id="PRO_0000371615"
FT STRAND 9..12
FT /evidence="ECO:0007829|PDB:6AZ1"
FT HELIX 17..23
FT /evidence="ECO:0007829|PDB:6AZ1"
FT TURN 24..27
FT /evidence="ECO:0007829|PDB:6AZ1"
FT HELIX 38..40
FT /evidence="ECO:0007829|PDB:6AZ1"
FT STRAND 41..44
FT /evidence="ECO:0007829|PDB:6AZ1"
FT STRAND 50..52
FT /evidence="ECO:0007829|PDB:6AZ1"
FT HELIX 54..68
FT /evidence="ECO:0007829|PDB:6AZ1"
FT HELIX 74..76
FT /evidence="ECO:0007829|PDB:6AZ1"
FT STRAND 77..83
FT /evidence="ECO:0007829|PDB:6AZ1"
FT TURN 84..86
FT /evidence="ECO:0007829|PDB:6AZ1"
FT HELIX 87..97
FT /evidence="ECO:0007829|PDB:6AZ1"
FT STRAND 100..104
FT /evidence="ECO:0007829|PDB:6AZ1"
FT TURN 108..112
FT /evidence="ECO:0007829|PDB:6AZ1"
FT STRAND 123..128
FT /evidence="ECO:0007829|PDB:6AZ1"
FT TURN 130..133
FT /evidence="ECO:0007829|PDB:6AZ1"
FT HELIX 134..140
FT /evidence="ECO:0007829|PDB:6AZ1"
FT TURN 141..144
FT /evidence="ECO:0007829|PDB:6AZ1"
FT STRAND 147..151
FT /evidence="ECO:0007829|PDB:6AZ1"
FT STRAND 161..166
FT /evidence="ECO:0007829|PDB:6AZ1"
FT HELIX 173..189
FT /evidence="ECO:0007829|PDB:6AZ1"
FT STRAND 194..196
FT /evidence="ECO:0007829|PDB:6AZ1"
FT HELIX 202..205
FT /evidence="ECO:0007829|PDB:6AZ1"
SQ SEQUENCE 246 AA; 27528 MW; C0CEF4DC97E98C7D CRC64;
MTAVESGSKV LRMKESDAQK LLAMRCHIGT RNQSSAMKKY IYGRTAEGSH IIDLHMMWEK
LILAARVIAA VENPKDVCVC SSRLYGTRAI YKFSQHVGTS FHGGRFIPGT FTNQIQKKFV
QPRVLVVTDP RTDHQAIREA SLVNIPVIAL CDTDAPLEYV DIAIPCNNRG IKSIGMMYWL
LAREVLRLRG TIVRSVPWEE KVDLFFYRDP NEAAEEKAAA AAAAPAAEAE EGFGWVERND
DNAWEA
