RSSA_PLAF7
ID RSSA_PLAF7 Reviewed; 263 AA.
AC Q8IJD4;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=40S ribosomal protein SA {ECO:0000255|HAMAP-Rule:MF_03015};
GN ORFNames=PF10_0264;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
CC -!- FUNCTION: Required for the assembly and/or stability of the 40S
CC ribosomal subunit. Required for the processing of the 20S rRNA-
CC precursor to mature 18S rRNA in a late step of the maturation of 40S
CC ribosomal subunits. {ECO:0000255|HAMAP-Rule:MF_03015}.
CC -!- SUBUNIT: Component of the small ribosomal subunit. Mature ribosomes
CC consist of a small (40S) and a large (60S) subunit. The 40S subunit
CC contains about 33 different proteins and 1 molecule of RNA (18S). The
CC 60S subunit contains about 49 different proteins and 3 molecules of RNA
CC (25S, 5.8S and 5S). Interacts with ribosomal protein S21.
CC {ECO:0000255|HAMAP-Rule:MF_03015}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03015}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS2 family.
CC {ECO:0000255|HAMAP-Rule:MF_03015}.
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DR EMBL; AE014185; AAN35461.1; -; Genomic_DNA.
DR RefSeq; XP_001347548.1; XM_001347512.1.
DR PDB; 3J7A; EM; 3.20 A; C=1-263.
DR PDB; 3JBN; EM; 4.70 A; C=10-204.
DR PDB; 3JBO; EM; 5.80 A; C=10-204.
DR PDB; 3JBP; EM; 6.70 A; C=10-204.
DR PDB; 6OKK; EM; 3.30 A; C=1-263.
DR PDBsum; 3J7A; -.
DR PDBsum; 3JBN; -.
DR PDBsum; 3JBO; -.
DR PDBsum; 3JBP; -.
DR PDBsum; 6OKK; -.
DR AlphaFoldDB; Q8IJD4; -.
DR SMR; Q8IJD4; -.
DR BioGRID; 1205835; 1.
DR IntAct; Q8IJD4; 2.
DR STRING; 5833.PF10_0264; -.
DR PRIDE; Q8IJD4; -.
DR EnsemblProtists; CZT98522; CZT98522; PF3D7_1026800.
DR GeneID; 810421; -.
DR KEGG; pfa:PF3D7_1026800; -.
DR VEuPathDB; PlasmoDB:PF3D7_1026800; -.
DR HOGENOM; CLU_058171_1_0_1; -.
DR InParanoid; Q8IJD4; -.
DR OMA; ENKMKRY; -.
DR PhylomeDB; Q8IJD4; -.
DR Reactome; R-PFA-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-PFA-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-PFA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-PFA-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-PFA-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-PFA-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-PFA-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-PFA-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-PFA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IDA:GeneDB.
DR GO; GO:0003735; F:structural constituent of ribosome; IDA:GeneDB.
DR GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR GO; GO:0000028; P:ribosomal small subunit assembly; IBA:GO_Central.
DR GO; GO:0006412; P:translation; ISS:GeneDB.
DR CDD; cd01425; RPS2; 1.
DR HAMAP; MF_03015; Ribosomal_S2_euk; 1.
DR InterPro; IPR001865; Ribosomal_S2.
DR InterPro; IPR018130; Ribosomal_S2_CS.
DR InterPro; IPR027498; Ribosomal_S2_euk.
DR InterPro; IPR005707; Ribosomal_S2_euk/arc.
DR InterPro; IPR023591; Ribosomal_S2_flav_dom_sf.
DR PANTHER; PTHR11489; PTHR11489; 1.
DR Pfam; PF00318; Ribosomal_S2; 2.
DR PRINTS; PR00395; RIBOSOMALS2.
DR SUPFAM; SSF52313; SSF52313; 1.
DR TIGRFAMs; TIGR01012; uS2_euk_arch; 1.
DR PROSITE; PS00962; RIBOSOMAL_S2_1; 1.
DR PROSITE; PS00963; RIBOSOMAL_S2_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..263
FT /note="40S ribosomal protein SA"
FT /id="PRO_0000371607"
FT HELIX 11..19
FT /evidence="ECO:0007829|PDB:3J7A"
FT TURN 20..23
FT /evidence="ECO:0007829|PDB:3J7A"
FT HELIX 31..36
FT /evidence="ECO:0007829|PDB:3J7A"
FT STRAND 37..40
FT /evidence="ECO:0007829|PDB:3J7A"
FT STRAND 42..44
FT /evidence="ECO:0007829|PDB:3J7A"
FT STRAND 46..48
FT /evidence="ECO:0007829|PDB:3J7A"
FT HELIX 51..66
FT /evidence="ECO:0007829|PDB:3J7A"
FT STRAND 67..69
FT /evidence="ECO:0007829|PDB:3J7A"
FT HELIX 70..72
FT /evidence="ECO:0007829|PDB:3J7A"
FT STRAND 73..76
FT /evidence="ECO:0007829|PDB:3J7A"
FT TURN 80..82
FT /evidence="ECO:0007829|PDB:3J7A"
FT HELIX 83..92
FT /evidence="ECO:0007829|PDB:3J7A"
FT TURN 104..108
FT /evidence="ECO:0007829|PDB:3J7A"
FT STRAND 119..124
FT /evidence="ECO:0007829|PDB:3J7A"
FT TURN 126..128
FT /evidence="ECO:0007829|PDB:3J7A"
FT HELIX 130..138
FT /evidence="ECO:0007829|PDB:3J7A"
FT STRAND 157..159
FT /evidence="ECO:0007829|PDB:3J7A"
FT STRAND 164..166
FT /evidence="ECO:0007829|PDB:3J7A"
FT HELIX 167..184
FT /evidence="ECO:0007829|PDB:3J7A"
FT STRAND 190..192
FT /evidence="ECO:0007829|PDB:3J7A"
FT STRAND 198..202
FT /evidence="ECO:0007829|PDB:3J7A"
SQ SEQUENCE 263 AA; 29856 MW; C43295E50C857B92 CRC64;
MSNKKGQSPK EESIAKMLIC KVHIGTKNLE NKMKRYVYTR AKDGVHIINL AKTYEKLQLA
ARIIVAISNP ADVVVVSARP FGSRAVLKFA QYTGAQAIAG RWTPGMLTNQ IIQKFTEPRL
LIVTDPRTDA QSVKESAYAN IPVIALCDSD SPLEHVDIAI PCNNKGKESI ALMYWLLAQE
VLYLKGVIPR SEPWNVMVDM FLWRDPEQFE LKNLANEENT PTAPHLIENQ YAAEAPYDEW
TKKEEWNDNT NEDWKNPIAA EEW
