ID   RSSB_ECO57              Reviewed;         337 AA.
AC   P0AEV2; P37055;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Regulator of RpoS {ECO:0000255|HAMAP-Rule:MF_00958};
GN   Name=rssB {ECO:0000255|HAMAP-Rule:MF_00958}; Synonyms=hnr;
GN   OrderedLocusNames=Z2011, ECs1737;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Regulates the turnover of the sigma S factor (RpoS) by
CC       promoting its proteolysis in exponentially growing cells. Acts by
CC       binding and delivering RpoS to the ClpXP protease. RssB is not co-
CC       degraded with RpoS, but is released from the complex and can initiate a
CC       new cycle of RpoS recognition and degradation. {ECO:0000255|HAMAP-
CC       Rule:MF_00958}.
CC   -!- SUBUNIT: Binds to RpoS. {ECO:0000255|HAMAP-Rule:MF_00958}.
CC   -!- PTM: Phosphorylated. Phosphorylation stimulates the interaction with
CC       RpoS and, therefore, the proteolysis of RpoS. {ECO:0000255|HAMAP-
CC       Rule:MF_00958}.
CC   -!- SIMILARITY: Belongs to the RssB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00958}.
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DR   EMBL; AE005174; AAG56092.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB35160.1; -; Genomic_DNA.
DR   PIR; A90846; A90846.
DR   PIR; H85703; H85703.
DR   RefSeq; NP_309764.1; NC_002695.1.
DR   RefSeq; WP_000193447.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AEV2; -.
DR   SMR; P0AEV2; -.
DR   STRING; 155864.EDL933_1938; -.
DR   EnsemblBacteria; AAG56092; AAG56092; Z2011.
DR   EnsemblBacteria; BAB35160; BAB35160; ECs_1737.
DR   GeneID; 58390554; -.
DR   GeneID; 913115; -.
DR   KEGG; ece:Z2011; -.
DR   KEGG; ecs:ECs_1737; -.
DR   PATRIC; fig|386585.9.peg.1837; -.
DR   eggNOG; COG0745; Bacteria.
DR   HOGENOM; CLU_055989_1_0_6; -.
DR   OMA; HWHLEYL; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR   GO; GO:0045862; P:positive regulation of proteolysis; IEA:UniProtKB-UniRule.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.60.40.10; -; 1.
DR   HAMAP; MF_00958; RssB; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR036457; PPM-type_dom_sf.
DR   InterPro; IPR028616; RssB.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Phosphoprotein; Reference proteome; Stress response.
FT   CHAIN           1..337
FT                   /note="Regulator of RpoS"
FT                   /id="PRO_0000081389"
FT   DOMAIN          9..123
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   MOD_RES         58
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00958"
SQ   SEQUENCE   337 AA;  37302 MW;  AB962EF94BC7B470 CRC64;
     MTQPLVGKQI LIVEDEQVFR SLLDSWFSSL GATTVLAADG VDALELLGGF TPDLMICDIA
     MPRMNGLKLL EHIRNRGDQT PVLVISATEN MADIAKALRL GVEDVLLKPV KDLNRLREMV
     FACLYPSMFN SRVEEEERLF RDWDAMVDNP AAAAKLLQEL QPPVQQVISH CRVNYRQLVA
     ADKPGLVLDI AALSENDLAF YCLDVTRAGH NGVLAALLLR ALFNGLLQEQ LAHQNQRLPE
     LGALLKQVNH LLRQANLPGQ FPLLVGYYHR ELKNLILVSA GLNATLNTGE HQVQISNGVP
     LGTLGNAYLN QLSQRCDAWQ CQIWGTGGRL RLMLSAE