RSSB_SHIFL
ID RSSB_SHIFL Reviewed; 337 AA.
AC P0AEV3; P37055;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Regulator of RpoS {ECO:0000255|HAMAP-Rule:MF_00958};
GN Name=rssB {ECO:0000255|HAMAP-Rule:MF_00958}; Synonyms=hnr;
GN OrderedLocusNames=SF1235, S1321;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Regulates the turnover of the sigma S factor (RpoS) by
CC promoting its proteolysis in exponentially growing cells. Acts by
CC binding and delivering RpoS to the ClpXP protease. RssB is not co-
CC degraded with RpoS, but is released from the complex and can initiate a
CC new cycle of RpoS recognition and degradation. {ECO:0000255|HAMAP-
CC Rule:MF_00958}.
CC -!- SUBUNIT: Binds to RpoS. {ECO:0000255|HAMAP-Rule:MF_00958}.
CC -!- PTM: Phosphorylated. Phosphorylation stimulates the interaction with
CC RpoS and, therefore, the proteolysis of RpoS. {ECO:0000255|HAMAP-
CC Rule:MF_00958}.
CC -!- SIMILARITY: Belongs to the RssB family. {ECO:0000255|HAMAP-
CC Rule:MF_00958}.
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DR EMBL; AE005674; AAN42848.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP16733.1; -; Genomic_DNA.
DR RefSeq; NP_707141.1; NC_004337.2.
DR RefSeq; WP_000193447.1; NZ_WPGW01000029.1.
DR AlphaFoldDB; P0AEV3; -.
DR SMR; P0AEV3; -.
DR STRING; 198214.SF1235; -.
DR EnsemblBacteria; AAN42848; AAN42848; SF1235.
DR EnsemblBacteria; AAP16733; AAP16733; S1321.
DR GeneID; 1024217; -.
DR GeneID; 58390554; -.
DR KEGG; sfl:SF1235; -.
DR KEGG; sfx:S1321; -.
DR PATRIC; fig|198214.7.peg.1453; -.
DR HOGENOM; CLU_055989_1_0_6; -.
DR OMA; HWHLEYL; -.
DR OrthoDB; 1635706at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR GO; GO:0045862; P:positive regulation of proteolysis; IEA:UniProtKB-UniRule.
DR GO; GO:0010468; P:regulation of gene expression; IEA:UniProtKB-UniRule.
DR Gene3D; 3.60.40.10; -; 1.
DR HAMAP; MF_00958; RssB; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR036457; PPM-type_dom_sf.
DR InterPro; IPR028616; RssB.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Phosphoprotein; Reference proteome; Stress response.
FT CHAIN 1..337
FT /note="Regulator of RpoS"
FT /id="PRO_0000081390"
FT DOMAIN 9..123
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT MOD_RES 58
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00958"
SQ SEQUENCE 337 AA; 37302 MW; AB962EF94BC7B470 CRC64;
MTQPLVGKQI LIVEDEQVFR SLLDSWFSSL GATTVLAADG VDALELLGGF TPDLMICDIA
MPRMNGLKLL EHIRNRGDQT PVLVISATEN MADIAKALRL GVEDVLLKPV KDLNRLREMV
FACLYPSMFN SRVEEEERLF RDWDAMVDNP AAAAKLLQEL QPPVQQVISH CRVNYRQLVA
ADKPGLVLDI AALSENDLAF YCLDVTRAGH NGVLAALLLR ALFNGLLQEQ LAHQNQRLPE
LGALLKQVNH LLRQANLPGQ FPLLVGYYHR ELKNLILVSA GLNATLNTGE HQVQISNGVP
LGTLGNAYLN QLSQRCDAWQ CQIWGTGGRL RLMLSAE
