RST2_SCHPO
ID RST2_SCHPO Reviewed; 567 AA.
AC P78871; Q9USD1;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1999, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Zinc finger protein rst2;
GN Name=rst2; ORFNames=SPAC6F12.02;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=10982411; DOI=10.1091/mbc.11.9.3205;
RA Kunitomo H., Higuchi T., Iino Y., Yamamoto M.;
RT "A zinc-finger protein, Rst2p, regulates transcription of the fission yeast
RT ste11(+) gene, which encodes a pivotal transcription factor for sexual
RT development.";
RL Mol. Biol. Cell 11:3205-3217(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 90-567.
RC STRAIN=PR745;
RX PubMed=9501991; DOI=10.1093/dnares/4.6.363;
RA Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
RT "Identification of open reading frames in Schizosaccharomyces pombe
RT cDNAs.";
RL DNA Res. 4:363-369(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 148-364.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
CC -!- FUNCTION: Key transcription factor for sexual development. Activates
CC the transcription of ste11. Binds to a stress response element-like
CC (SRE) region in the ste11 promoter. {ECO:0000269|PubMed:10982411}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB025941; BAA89273.1; -; Genomic_DNA.
DR EMBL; CU329670; CAB11086.1; -; Genomic_DNA.
DR EMBL; D89221; BAA13882.1; -; mRNA.
DR EMBL; AB027851; BAA87155.1; -; Genomic_DNA.
DR PIR; T11653; T11653.
DR RefSeq; NP_593288.1; NM_001018718.2.
DR AlphaFoldDB; P78871; -.
DR SMR; P78871; -.
DR BioGRID; 279467; 10.
DR STRING; 4896.SPAC6F12.02.1; -.
DR iPTMnet; P78871; -.
DR MaxQB; P78871; -.
DR PaxDb; P78871; -.
DR PRIDE; P78871; -.
DR EnsemblFungi; SPAC6F12.02.1; SPAC6F12.02.1:pep; SPAC6F12.02.
DR GeneID; 2543031; -.
DR KEGG; spo:SPAC6F12.02; -.
DR PomBase; SPAC6F12.02; rst2.
DR VEuPathDB; FungiDB:SPAC6F12.02; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_459387_0_0_1; -.
DR InParanoid; P78871; -.
DR OMA; KVKQYVC; -.
DR PRO; PR:P78871; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; IDA:PomBase.
DR GO; GO:0000792; C:heterochromatin; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0001216; F:DNA-binding transcription activator activity; IDA:PomBase.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:PomBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:PomBase.
DR GO; GO:0008270; F:zinc ion binding; IDA:PomBase.
DR GO; GO:0010514; P:induction of conjugation with cellular fusion; IMP:PomBase.
DR GO; GO:1900237; P:positive regulation of induction of conjugation with cellular fusion; IMP:PomBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:PomBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..567
FT /note="Zinc finger protein rst2"
FT /id="PRO_0000046883"
FT ZN_FING 70..92
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 98..128
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 123..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 156
FT /note="T -> P (in Ref. 4; BAA87155)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 567 AA; 62560 MW; 1E5CF026E5FAEF5F CRC64;
MTRESLAPIA SKANTLSESK VSENLMSINS DSGTSNANTP SSVTSNSKPV ASSTAAKKDP
NAPPQKVKQY VCETCTRAFA RLEHLKRHIR SHTNEKPFTC SEIDGLPTGC GRQFSRRDLL
LRHQQKIHRN PQPRRRRRST TALPNPSLSN VSVSTTNLAS KPVISLPQAD SIDKFRYPKL
HAALQAQLAN NSGSFSASWL QAQQQRLVSA GNGRETVNAS ASGAVNPTSS QWSDQRLGVP
YGPDSPLYYR RATIASDLRP SVYQHPQLYD FNRPESLSGQ LDDESLARMP YSPNAVSRNY
AMNMTLPESI PEGYEIDKLD WMSFSESLNL PTFNQPSGPS DVSASFLNLQ AMPSPHASPK
DSLINKSNSY FFQNPPKSNS VDYTRLDNLE HMRQSCISPS GTNFSPSCYS PESLMQQPLT
LSPSSIPSGL PTYAHVNSPL GTEQYPSEAY PPKGYVDMEG RISEGIKEEG ISLSEEITDK
DQAFASMGYF DSYNFEGVEN SNSLNNEGDQ METNFQSEKL DNSNSIPFFN FNSFNNNGAN
WSSDFNYPVS ETSGLLTDNN RNQPPSF
