ID   RSU1_BOVIN              Reviewed;         277 AA.
AC   Q5E9C0;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Ras suppressor protein 1;
DE            Short=Rsu-1;
GN   Name=RSU1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potentially plays a role in the Ras signal transduction
CC       pathway. Capable of suppressing v-Ras transformation in vitro (By
CC       similarity). {ECO:0000250}.
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DR   EMBL; BT021000; AAX09017.1; -; mRNA.
DR   EMBL; BC102118; AAI02119.1; -; mRNA.
DR   RefSeq; NP_001035691.1; NM_001040601.2.
DR   AlphaFoldDB; Q5E9C0; -.
DR   SMR; Q5E9C0; -.
DR   STRING; 9913.ENSBTAP00000039209; -.
DR   PaxDb; Q5E9C0; -.
DR   PRIDE; Q5E9C0; -.
DR   Ensembl; ENSBTAT00000039415; ENSBTAP00000039209; ENSBTAG00000027446.
DR   GeneID; 617534; -.
DR   KEGG; bta:617534; -.
DR   CTD; 6251; -.
DR   VEuPathDB; HostDB:ENSBTAG00000027446; -.
DR   VGNC; VGNC:57022; RSU1.
DR   eggNOG; KOG0617; Eukaryota.
DR   GeneTree; ENSGT00940000158676; -.
DR   HOGENOM; CLU_000288_18_15_1; -.
DR   InParanoid; Q5E9C0; -.
DR   OMA; RHMQGGR; -.
DR   OrthoDB; 1382533at2759; -.
DR   TreeFam; TF314790; -.
DR   Proteomes; UP000009136; Chromosome 13.
DR   Bgee; ENSBTAG00000027446; Expressed in myometrium and 105 other tissues.
DR   ExpressionAtlas; Q5E9C0; baseline and differential.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 2.
DR   SMART; SM00369; LRR_TYP; 7.
DR   PROSITE; PS51450; LRR; 7.
PE   2: Evidence at transcript level;
KW   Acetylation; Leucine-rich repeat; Reference proteome; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q15404"
FT   CHAIN           2..276
FT                   /note="Ras suppressor protein 1"
FT                   /id="PRO_0000273968"
FT   REPEAT          41..63
FT                   /note="LRR 1"
FT   REPEAT          64..85
FT                   /note="LRR 2"
FT   REPEAT          87..109
FT                   /note="LRR 3"
FT   REPEAT          110..133
FT                   /note="LRR 4"
FT   REPEAT          135..156
FT                   /note="LRR 5"
FT   REPEAT          158..179
FT                   /note="LRR 6"
FT   REPEAT          181..202
FT                   /note="LRR 7"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          250..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        255..269
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15404"
SQ   SEQUENCE   277 AA;  31537 MW;  4094EABC0D75999C CRC64;
     MSKSLKKLVE ESREKNQPEV DMSDRGISNM LDINGLFTLS HITQLVLSHN KLTTVPPNIA
     ELKNLEVLNF FNNQIEELPT QISSLQKLKH LNLGMNRLNT LPRGFGSLPA LEVLDLTYNN
     LNENSLPGNF FYLTTLRALY LSDNDFEILP PDIGKLTKLQ ILSLRDNDLI SLPKEIGELT
     QLKELHIQGN RLTVLPPELG NLDLTGQKQI FKAENNPWVT PIADQFQLGV SHVFEYIRSE
     TYKYLYGRHM QANPEPPKKN NDKSKKISRK PLAAKNK