RSVR_COTJA
ID RSVR_COTJA Reviewed; 157 AA.
AC P98162;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Subgroup A Rous sarcoma virus receptor pg950;
DE AltName: Full=Low density lipoprotein receptor-related protein;
DE Flags: Precursor;
OS Coturnix japonica (Japanese quail) (Coturnix coturnix japonica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Perdicinae; Coturnix.
OX NCBI_TaxID=93934;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PG800 AND PG950).
RX PubMed=8402880; DOI=10.1016/0092-8674(93)90726-7;
RA Bates P., Young J.A.T., Varmus H.E.;
RT "A receptor for subgroup A Rous sarcoma virus is related to the low density
RT lipoprotein receptor.";
RL Cell 74:1043-1051(1993).
RN [2]
RP STRUCTURE BY NMR OF 30-70, AND DISULFIDE BONDS.
RX PubMed=11768384; DOI=10.1016/s0014-5793(01)03086-1;
RA Tonelli M., Peters R.J., James T.L., Agard D.A.;
RT "The solution structure of the viral binding domain of Tva, the cellular
RT receptor for subgroup A avian leukosis and sarcoma virus.";
RL FEBS Lett. 509:161-168(2001).
RN [3]
RP STRUCTURE BY NMR OF 28-72, AND DISULFIDE BONDS.
RX PubMed=11861852; DOI=10.1128/jvi.76.6.2848-2856.2002;
RA Wang Q.-Y., Huang W., Dolmer K., Gettins P.G., Rong L.;
RT "Solution structure of the viral receptor domain of Tva and its
RT implications in viral entry.";
RL J. Virol. 76:2848-2856(2002).
CC -!- FUNCTION: Responsible for susceptibility to the retrovirus subgroup A
CC Rous sarcoma virus.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=pg950; Synonyms=Tva950;
CC IsoId=P98162-1; Sequence=Displayed;
CC Name=pg800; Synonyms=Tva800;
CC IsoId=P98162-2; Sequence=VSP_004378, VSP_004379;
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DR EMBL; L22752; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; L22753; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; A48837; A48837.
DR PIR; B48837; B48837.
DR PDB; 1JRF; NMR; -; A=28-72.
DR PDB; 1K7B; NMR; -; A=30-70.
DR PDBsum; 1JRF; -.
DR PDBsum; 1K7B; -.
DR AlphaFoldDB; P98162; -.
DR SMR; P98162; -.
DR EvolutionaryTrace; P98162; -.
DR Proteomes; UP000694412; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 4.10.400.10; -; 1.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR SMART; SM00192; LDLa; 1.
DR SUPFAM; SSF57424; SSF57424; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Disulfide bond; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..157
FT /note="Subgroup A Rous sarcoma virus receptor pg950"
FT /id="PRO_0000022252"
FT TOPO_DOM 20..102
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..157
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 28..71
FT /note="LDL-receptor class A"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 24
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 81
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 30..47
FT DISULFID 37..60
FT DISULFID 54..69
FT VAR_SEQ 110..120
FT /note="VLLCCLVAVGG -> GIFCCELVRWD (in isoform pg800)"
FT /evidence="ECO:0000303|PubMed:8402880"
FT /id="VSP_004378"
FT VAR_SEQ 121..157
FT /note="Missing (in isoform pg800)"
FT /evidence="ECO:0000303|PubMed:8402880"
FT /id="VSP_004379"
FT STRAND 37..39
FT /evidence="ECO:0007829|PDB:1JRF"
FT TURN 45..47
FT /evidence="ECO:0007829|PDB:1JRF"
FT HELIX 49..52
FT /evidence="ECO:0007829|PDB:1JRF"
FT STRAND 53..57
FT /evidence="ECO:0007829|PDB:1JRF"
FT STRAND 60..63
FT /evidence="ECO:0007829|PDB:1JRF"
FT TURN 64..66
FT /evidence="ECO:0007829|PDB:1K7B"
FT HELIX 67..70
FT /evidence="ECO:0007829|PDB:1JRF"
SQ SEQUENCE 157 AA; 16355 MW; 726BB89AD96B7A66 CRC64;
MARLLPALLL LLLPGNVTGN GSGNGSLSRC PPGQFRCSEP PGAHGECYPQ DWLCDGHPDC
DDGRDEWGCG TSATPAVPTD NGTEAPTVPA PGRALPARNH GRMWMLITAV LLCCLVAVGG
IAAWGKSKAK SRSDIFSLAS ASKELLVPDK SQADLFS
