ABCF2_HUMAN
ID ABCF2_HUMAN Reviewed; 623 AA.
AC Q9UG63; O60864; Q75MJ0; Q75MJ1; Q96TE8;
DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2001, sequence version 2.
DT 03-AUG-2022, entry version 185.
DE RecName: Full=ATP-binding cassette sub-family F member 2;
DE AltName: Full=Iron-inhibited ABC transporter 2;
GN Name=ABCF2; ORFNames=HUSSY-18;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=10944468; DOI=10.1006/bbrc.2000.3282;
RA Ye Z., Connor J.R.;
RT "cDNA cloning by amplification of circularized first strand cDNAs reveals
RT non-IRE-regulated iron-responsive mRNAs.";
RL Biochem. Biophys. Res. Commun. 275:223-227(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Uterus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 74-623.
RC TISSUE=Lung;
RX PubMed=11124703;
RX DOI=10.1002/1097-0061(200101)18:1<69::aid-yea647>3.0.co;2-h;
RA Stanchi F., Bertocco E., Toppo S., Dioguardi R., Simionati B., Cannata N.,
RA Zimbello R., Lanfranchi G., Valle G.;
RT "Characterization of 16 novel human genes showing high similarity to yeast
RT sequences.";
RL Yeast 18:69-80(2001).
RN [8]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-304, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-218 AND SER-512, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9UG63-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UG63-2; Sequence=VSP_054715;
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCF family.
CC EF3 subfamily. {ECO:0000305}.
CC -!- CAUTION: Lacks transmembrane domains and is probably not involved in
CC transport. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=ABCMdb; Note=Database for mutations in ABC proteins;
CC URL="http://abcm2.hegelab.org/search";
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DR EMBL; AF261091; AAG13902.1; -; mRNA.
DR EMBL; AF261092; AAG13903.1; -; mRNA.
DR EMBL; BT007451; AAP36119.1; -; mRNA.
DR EMBL; AL050291; CAB43392.1; -; mRNA.
DR EMBL; AC021097; AAS00378.1; -; Genomic_DNA.
DR EMBL; AC021097; AAS00379.1; -; Genomic_DNA.
DR EMBL; CH471173; EAW54014.1; -; Genomic_DNA.
DR EMBL; CH471173; EAW54016.1; -; Genomic_DNA.
DR EMBL; CH471173; EAW54017.1; -; Genomic_DNA.
DR EMBL; BC001661; AAH01661.1; -; mRNA.
DR EMBL; AJ005016; CAA06290.1; -; mRNA.
DR CCDS; CCDS5923.1; -. [Q9UG63-1]
DR PIR; T08810; T08810.
DR RefSeq; NP_005683.2; NM_005692.4. [Q9UG63-2]
DR RefSeq; NP_009120.1; NM_007189.2. [Q9UG63-1]
DR RefSeq; XP_016867128.1; XM_017011639.1.
DR RefSeq; XP_016867129.1; XM_017011640.1.
DR AlphaFoldDB; Q9UG63; -.
DR SMR; Q9UG63; -.
DR BioGRID; 115372; 120.
DR CORUM; Q9UG63; -.
DR IntAct; Q9UG63; 39.
DR MINT; Q9UG63; -.
DR STRING; 9606.ENSP00000222388; -.
DR TCDB; 3.A.1.121.11; the atp-binding cassette (abc) superfamily.
DR GlyGen; Q9UG63; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9UG63; -.
DR MetOSite; Q9UG63; -.
DR PhosphoSitePlus; Q9UG63; -.
DR SwissPalm; Q9UG63; -.
DR BioMuta; ABCF2; -.
DR DMDM; 12643306; -.
DR EPD; Q9UG63; -.
DR jPOST; Q9UG63; -.
DR MassIVE; Q9UG63; -.
DR MaxQB; Q9UG63; -.
DR PaxDb; Q9UG63; -.
DR PeptideAtlas; Q9UG63; -.
DR PRIDE; Q9UG63; -.
DR ProteomicsDB; 84202; -. [Q9UG63-1]
DR Antibodypedia; 18732; 365 antibodies from 30 providers.
DR DNASU; 10061; -.
DR Ensembl; ENST00000287844.7; ENSP00000287844.2; ENSG00000033050.9. [Q9UG63-1]
DR GeneID; 10061; -.
DR GeneID; 114483834; -.
DR KEGG; hsa:10061; -.
DR KEGG; hsa:114483834; -.
DR MANE-Select; ENST00000287844.7; ENSP00000287844.2; NM_007189.3; NP_009120.1.
DR UCSC; uc003wjo.3; human. [Q9UG63-1]
DR CTD; 10061; -.
DR CTD; 114483834; -.
DR DisGeNET; 10061; -.
DR DisGeNET; 114483834; -.
DR GeneCards; ABCF2; -.
DR HGNC; HGNC:71; ABCF2.
DR HPA; ENSG00000033050; Low tissue specificity.
DR HPA; ENSG00000285292; Low tissue specificity.
DR MIM; 612510; gene.
DR neXtProt; NX_Q9UG63; -.
DR OpenTargets; ENSG00000033050; -.
DR PharmGKB; PA24406; -.
DR VEuPathDB; HostDB:ENSG00000033050; -.
DR VEuPathDB; HostDB:ENSG00000285292; -.
DR eggNOG; KOG0927; Eukaryota.
DR GeneTree; ENSGT00630000089910; -.
DR HOGENOM; CLU_000604_36_6_1; -.
DR InParanoid; Q9UG63; -.
DR OMA; DKMFLDN; -.
DR PhylomeDB; Q9UG63; -.
DR TreeFam; TF105208; -.
DR PathwayCommons; Q9UG63; -.
DR SignaLink; Q9UG63; -.
DR BioGRID-ORCS; 10061; 24 hits in 1080 CRISPR screens.
DR ChiTaRS; ABCF2; human.
DR GeneWiki; ABCF2; -.
DR GenomeRNAi; 10061; -.
DR Pharos; Q9UG63; Tbio.
DR PRO; PR:Q9UG63; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9UG63; protein.
DR Bgee; ENSG00000033050; Expressed in sural nerve and 176 other tissues.
DR ExpressionAtlas; Q9UG63; baseline and differential.
DR Genevisible; Q9UG63; HS.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR032781; ABC_tran_Xtn.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF12848; ABC_tran_Xtn; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; ATP-binding; Nucleotide-binding;
KW Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..623
FT /note="ATP-binding cassette sub-family F member 2"
FT /id="PRO_0000093323"
FT DOMAIN 86..325
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 396..613
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 118..125
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 430..437
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT MOD_RES 218
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 304
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:19608861"
FT MOD_RES 512
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 623
FT /note="V -> VCTLTLASLPRP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_054715"
FT CONFLICT 39
FT /note="V -> A (in Ref. 1; AAG13902/AAG13903)"
FT /evidence="ECO:0000305"
FT CONFLICT 74
FT /note="T -> A (in Ref. 7; CAA06290)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 623 AA; 71290 MW; 702A968BCF8061AE CRC64;
MPSDLAKKKA AKKKEAAKAR QRPRKGHEEN GDVVTEPQVA EKNEANGRET TEVDLLTKEL
EDFEMKKAAA RAVTGVLASH PNSTDVHIIN LSLTFHGQEL LSDTKLELNS GRRYGLIGLN
GIGKSMLLSA IGKREVPIPE HIDIYHLTRE MPPSDKTPLH CVMEVDTERA MLEKEAERLA
HEDAECEKLM ELYERLEELD ADKAEMRASR ILHGLGFTPA MQRKKLKDFS GGWRMRVALA
RALFIRPFML LLDEPTNHLD LDACVWLEEE LKTFKRILVL VSHSQDFLNG VCTNIIHMHN
KKLKYYTGNY DQYVKTRLEL EENQMKRFHW EQDQIAHMKN YIARFGHGSA KLARQAQSKE
KTLQKMMASG LTERVVSDKT LSFYFPPCGK IPPPVIMVQN VSFKYTKDGP CIYNNLEFGI
DLDTRVALVG PNGAGKSTLL KLLTGELLPT DGMIRKHSHV KIGRYHQHLQ EQLDLDLSPL
EYMMKCYPEI KEKEEMRKII GRYGLTGKQQ VSPIRNLSDG QKCRVCLAWL AWQNPHMLFL
DEPTNHLDIE TIDALADAIN EFEGGMMLVS HDFRLIQQVA QEIWVCEKQT ITKWPGDILA
YKEHLKSKLV DEEPQLTKRT HNV
