BCL6B_HUMAN
ID BCL6B_HUMAN Reviewed; 479 AA.
AC Q8N143; Q6PCB4;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=B-cell CLL/lymphoma 6 member B protein;
DE AltName: Full=Bcl6-associated zinc finger protein;
DE AltName: Full=Zinc finger protein 62;
GN Name=BCL6B; Synonyms=BAZF, ZNF62;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=11855826; DOI=10.1006/bbrc.2002.6481;
RA Sakashita C., Fukuda T., Okabe S., Kobayashi H., Hirosawa S., Tokuhisa T.,
RA Miyasaka N., Miura O., Miki T.;
RT "Cloning and characterization of the human BAZF gene, a homologue of the
RT BCL6 oncogene.";
RL Biochem. Biophys. Res. Commun. 291:567-573(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Acts as a sequence-specific transcriptional repressor in
CC association with BCL6. May function in a narrow stage or be related to
CC some events in the early B-cell development.
CC {ECO:0000269|PubMed:11855826}.
CC -!- SUBUNIT: Associates with BCL6 through the BTB domain. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed with higher expression found
CC in heart and placenta. {ECO:0000269|PubMed:11855826}.
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DR EMBL; AB076580; BAC00962.1; -; mRNA.
DR EMBL; AB076581; BAC00963.1; -; Genomic_DNA.
DR EMBL; AC040977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC059404; AAH59404.1; -; mRNA.
DR CCDS; CCDS42248.1; -.
DR PIR; JC7812; JC7812.
DR RefSeq; NP_862827.1; NM_181844.3.
DR AlphaFoldDB; Q8N143; -.
DR SMR; Q8N143; -.
DR BioGRID; 129125; 33.
DR IntAct; Q8N143; 2.
DR STRING; 9606.ENSP00000293805; -.
DR iPTMnet; Q8N143; -.
DR PhosphoSitePlus; Q8N143; -.
DR BioMuta; BCL6B; -.
DR DMDM; 296434409; -.
DR jPOST; Q8N143; -.
DR MassIVE; Q8N143; -.
DR PaxDb; Q8N143; -.
DR PeptideAtlas; Q8N143; -.
DR PRIDE; Q8N143; -.
DR ProteomicsDB; 71552; -.
DR TopDownProteomics; Q8N143; -.
DR Antibodypedia; 23875; 82 antibodies from 23 providers.
DR DNASU; 255877; -.
DR Ensembl; ENST00000293805.10; ENSP00000293805.5; ENSG00000161940.11.
DR GeneID; 255877; -.
DR KEGG; hsa:255877; -.
DR MANE-Select; ENST00000293805.10; ENSP00000293805.5; NM_181844.4; NP_862827.2.
DR UCSC; uc010clt.2; human.
DR CTD; 255877; -.
DR DisGeNET; 255877; -.
DR GeneCards; BCL6B; -.
DR HGNC; HGNC:1002; BCL6B.
DR HPA; ENSG00000161940; Low tissue specificity.
DR MIM; 608992; gene.
DR neXtProt; NX_Q8N143; -.
DR OpenTargets; ENSG00000161940; -.
DR PharmGKB; PA25313; -.
DR VEuPathDB; HostDB:ENSG00000161940; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000159844; -.
DR HOGENOM; CLU_024196_2_0_1; -.
DR InParanoid; Q8N143; -.
DR OMA; VCGARFN; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8N143; -.
DR TreeFam; TF330912; -.
DR PathwayCommons; Q8N143; -.
DR SignaLink; Q8N143; -.
DR BioGRID-ORCS; 255877; 10 hits in 1136 CRISPR screens.
DR GenomeRNAi; 255877; -.
DR Pharos; Q8N143; Tbio.
DR PRO; PR:Q8N143; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8N143; protein.
DR Bgee; ENSG00000161940; Expressed in upper lobe of left lung and 146 other tissues.
DR ExpressionAtlas; Q8N143; baseline and differential.
DR Genevisible; Q8N143; HS.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045595; P:regulation of cell differentiation; IBA:GO_Central.
DR GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR GO; GO:0002682; P:regulation of immune system process; IBA:GO_Central.
DR GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0042092; P:type 2 immune response; IBA:GO_Central.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..479
FT /note="B-cell CLL/lymphoma 6 member B protein"
FT /id="PRO_0000047100"
FT DOMAIN 38..105
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT ZN_FING 328..350
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 356..378
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 384..406
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 412..434
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 440..463
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 143..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..165
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 244
FT /note="S -> SS (in Ref. 1; BAC00962/BAC00963 and 3;
FT AAH59404)"
FT /evidence="ECO:0000305"
FT CONFLICT 306
FT /note="C -> S (in Ref. 3; AAH59404)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 479 AA; 51531 MW; AB04E3331A7DB8E6 CRC64;
MGSPAAPEGA LGYVREFTRH SSDVLGNLNE LRLRGILTDV TLLVGGQPLR AHKAVLIACS
GFFYSIFRGR AGVGVDVLSL PGGPEARGFA PLLDFMYTSR LRLSPATAPA VLAAATYLQM
EHVVQACHRF IQASYEPLGI SLRPLEAEPP TPPTAPPPGS PRRSEGHPDP PTESRSCSQG
PPSPASPDPK ACNWKKYKYI VLNSQASQAG SLVGERSSGQ PCPQARLPSG DEASSSSSSS
SSSSEEGPIP GPQSRLSPTA ATVQFKCGAP ASTPYLLTSQ AQDTSGSPSE RARPLPGSEF
FSCQNCEAVA GCSSGLDSLV PGDEDKPYKC QLCRSSFRYK GNLASHRTVH TGEKPYHCSI
CGARFNRPAN LKTHSRIHSG EKPYKCETCG SRFVQVAHLR AHVLIHTGEK PYPCPTCGTR
FRHLQTLKSH VRIHTGEKPY HCDPCGLHFR HKSQLRLHLR QKHGAATNTK VHYHILGGP
