ABCF2_MOUSE
ID ABCF2_MOUSE Reviewed; 628 AA.
AC Q99LE6; Q3UA24; Q8C1S5; Q9JL48;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=ATP-binding cassette sub-family F member 2;
GN Name=Abcf2 {ECO:0000312|MGI:MGI:1351657};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Bone marrow, Brain, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2] {ECO:0000312|EMBL:AAH03300.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N {ECO:0000312|EMBL:AAH03300.1};
RC TISSUE=Mammary gland {ECO:0000312|EMBL:AAH03300.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAF31422.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 376-628.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAF31422.1};
RX PubMed=10708515; DOI=10.1006/geno.1999.6102;
RA Schriml L.M., Dean M.;
RT "Identification of 18 mouse ABC genes and characterization of the ABC
RT superfamily in Mus musculus.";
RL Genomics 64:24-31(2000).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCF family.
CC EF3 subfamily. {ECO:0000305}.
CC -!- CAUTION: Lacks transmembrane domains and is probably not involved in
CC transport. {ECO:0000305}.
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DR EMBL; AK003005; BAC25016.1; -; mRNA.
DR EMBL; AK087990; BAC40079.1; -; mRNA.
DR EMBL; AK147937; BAE28242.1; -; mRNA.
DR EMBL; AK151545; BAE30491.1; -; mRNA.
DR EMBL; BC003300; AAH03300.1; -; mRNA.
DR EMBL; AF213382; AAF31422.1; -; mRNA.
DR CCDS; CCDS19125.1; -.
DR RefSeq; NP_001177372.1; NM_001190443.1.
DR RefSeq; NP_038881.1; NM_013853.2.
DR RefSeq; XP_006535789.1; XM_006535726.3.
DR RefSeq; XP_006535790.1; XM_006535727.3.
DR AlphaFoldDB; Q99LE6; -.
DR SMR; Q99LE6; -.
DR BioGRID; 205214; 20.
DR IntAct; Q99LE6; 2.
DR STRING; 10090.ENSMUSP00000030795; -.
DR iPTMnet; Q99LE6; -.
DR PhosphoSitePlus; Q99LE6; -.
DR EPD; Q99LE6; -.
DR MaxQB; Q99LE6; -.
DR PaxDb; Q99LE6; -.
DR PeptideAtlas; Q99LE6; -.
DR PRIDE; Q99LE6; -.
DR ProteomicsDB; 285957; -.
DR DNASU; 27407; -.
DR Ensembl; ENSMUST00000030795; ENSMUSP00000030795; ENSMUSG00000028953.
DR GeneID; 27407; -.
DR KEGG; mmu:27407; -.
DR UCSC; uc008wsb.2; mouse.
DR CTD; 10061; -.
DR MGI; MGI:1351657; Abcf2.
DR VEuPathDB; HostDB:ENSMUSG00000028953; -.
DR eggNOG; KOG0927; Eukaryota.
DR GeneTree; ENSGT00630000089910; -.
DR HOGENOM; CLU_000604_36_6_1; -.
DR InParanoid; Q99LE6; -.
DR OMA; DKMFLDN; -.
DR OrthoDB; 580544at2759; -.
DR PhylomeDB; Q99LE6; -.
DR TreeFam; TF105208; -.
DR BioGRID-ORCS; 27407; 5 hits in 73 CRISPR screens.
DR ChiTaRS; Abcf2; mouse.
DR PRO; PR:Q99LE6; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q99LE6; protein.
DR Bgee; ENSMUSG00000028953; Expressed in hindlimb stylopod muscle and 250 other tissues.
DR Genevisible; Q99LE6; MM.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR032781; ABC_tran_Xtn.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF12848; ABC_tran_Xtn; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 1: Evidence at protein level;
KW Acetylation; ATP-binding; Nucleotide-binding; Phosphoprotein;
KW Reference proteome; Repeat.
FT CHAIN 1..628
FT /note="ATP-binding cassette sub-family F member 2"
FT /id="PRO_0000093324"
FT DOMAIN 91..330
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 401..618
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 123..130
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 435..442
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT MOD_RES 223
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UG63"
FT MOD_RES 309
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9UG63"
FT MOD_RES 517
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UG63"
FT CONFLICT 537
FT /note="W -> R (in Ref. 3; AAF31422)"
FT /evidence="ECO:0000305"
FT CONFLICT 579
FT /note="R -> I (in Ref. 3; AAF31422)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 628 AA; 71782 MW; 66E0C76F29A82BD8 CRC64;
MPSDLAKKKA AKKKEAAKAR QRPRKGHEEN GDAVTEPQVA EEKIEEANGR ETTGDGEVDL
LTKELEDFEM KKAAARAVTG VLASHPNSTD VHIINLSLTF HGQELLSDTK LELNSGRRYG
LIGLNGIGKS MLLSAIGKRE VPIPEHIDIY HLTREMPPSE KTPLQCVMEV DTERAMLERE
AERLAHEDAE CEKLMELYER LEELDADKAE MRASRILHGL GFTPAMQRKK LKDFSGGWRM
RVALARALFI RPFMLLLDEP TNHLDLDACV WLEEELKTFK RILVLVSHSQ DFLNGVCTNI
IHMHNKKLKY YTGNYDQYVK TRLELEENQM KRFHWEQDQI AHMKNYIARF GHGSAKLARQ
AQSKEKTLQK MMASGLTERV VSDKTLSFYF PPCGKIPPPV IMVQNVSFKY TKDGPCIYNN
LEFGIDLDTR VALVGPNGAG KSTLLKLLTG ELLPTDGMIR KHSHVKIGRY HQHLQEQLDL
DLSPLEYMMK CYPEIKEKEE MRKIIGRYGL TGKQQVSPIR NLSDGQKCRV CLAWLAWQNP
HMLFLDEPTN HLDIETIDAL ADAINEFEGG MMLVSHDFRL IQQVAQEIWV CEKQTITKWP
GDILAYKEHL KSKLVDEEPQ LTKRTHNV
