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BCL7A_HUMAN
ID   BCL7A_HUMAN             Reviewed;         210 AA.
AC   Q4VC05; B4DJN6; B7ZB21; Q13843; Q14CT7;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=B-cell CLL/lymphoma 7 protein family member A;
GN   Name=BCL7A;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND CHROMOSOMAL TRANSLOCATION.
RC   TISSUE=Brain;
RX   PubMed=8605326;
RA   Zani V.J., Asou N., Jadayel D., Heward J.M., Shipley J., Nacheva E.,
RA   Takasuki K., Catovsky D., Dyer M.J.S.;
RT   "Molecular cloning of complex chromosomal translocation
RT   t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new
RT   gene (BCL7A) with homology to caldesmon.";
RL   Blood 87:3124-3134(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Kidney, and Thalamus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203 AND SER-207, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Embryonic kidney;
RX   PubMed=17525332; DOI=10.1126/science.1140321;
RA   Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E.,
RA   Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA   Gygi S.P., Elledge S.J.;
RT   "ATM and ATR substrate analysis reveals extensive protein networks
RT   responsive to DNA damage.";
RL   Science 316:1160-1166(2007).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA   Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT   "System-wide temporal characterization of the proteome and phosphoproteome
RT   of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:RS3-RS3(2011).
RN   [8]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [9]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [10]
RP   SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-199, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25218447; DOI=10.1038/nsmb.2890;
RA   Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M.,
RA   Vertegaal A.C.;
RT   "Uncovering global SUMOylation signaling networks in a site-specific
RT   manner.";
RL   Nat. Struct. Mol. Biol. 21:927-936(2014).
CC   -!- INTERACTION:
CC       Q4VC05; P13196: ALAS1; NbExp=3; IntAct=EBI-359917, EBI-3905054;
CC       Q4VC05-2; Q92624: APPBP2; NbExp=3; IntAct=EBI-12065992, EBI-743771;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=Isoform b;
CC         IsoId=Q4VC05-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q4VC05-2; Sequence=VSP_019271;
CC   -!- DISEASE: Note=Chromosomal aberrations involving BCL7A may be a cause of
CC       B-cell non-Hodgkin lymphoma. Three-way translocation
CC       t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene
CC       regions. {ECO:0000269|PubMed:8605326}.
CC   -!- SIMILARITY: Belongs to the BCL7 family. {ECO:0000305}.
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DR   EMBL; X89984; CAA62011.1; -; mRNA.
DR   EMBL; AK296159; BAG58898.1; -; mRNA.
DR   EMBL; AK316486; BAH14857.1; -; mRNA.
DR   EMBL; CH471054; EAW98302.1; -; Genomic_DNA.
DR   EMBL; BC094723; AAH94723.1; -; mRNA.
DR   EMBL; BC113627; AAI13628.1; -; mRNA.
DR   CCDS; CCDS53841.1; -. [Q4VC05-1]
DR   CCDS; CCDS9226.1; -. [Q4VC05-2]
DR   PIR; S58237; S58245.
DR   RefSeq; NP_001019979.1; NM_001024808.2. [Q4VC05-1]
DR   RefSeq; NP_066273.1; NM_020993.4. [Q4VC05-2]
DR   AlphaFoldDB; Q4VC05; -.
DR   BioGRID; 107077; 109.
DR   ComplexPortal; CPX-1195; Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex.
DR   ComplexPortal; CPX-4084; GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA2 variant.
DR   ComplexPortal; CPX-4203; GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA2 variant.
DR   ComplexPortal; CPX-4206; GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA4 variant.
DR   ComplexPortal; CPX-4207; GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA4 variant.
DR   ComplexPortal; CPX-4223; GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA2 variant.
DR   ComplexPortal; CPX-4224; GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRAL-SMARCA2 variant.
DR   ComplexPortal; CPX-4225; GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA4 variant.
DR   ComplexPortal; CPX-4226; GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRAL-SMARCA4 variant.
DR   DIP; DIP-27608N; -.
DR   IntAct; Q4VC05; 99.
DR   MINT; Q4VC05; -.
DR   STRING; 9606.ENSP00000445868; -.
DR   ChEMBL; CHEMBL4630829; -.
DR   GlyGen; Q4VC05; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q4VC05; -.
DR   MetOSite; Q4VC05; -.
DR   PhosphoSitePlus; Q4VC05; -.
DR   BioMuta; BCL7A; -.
DR   DMDM; 74754614; -.
DR   EPD; Q4VC05; -.
DR   jPOST; Q4VC05; -.
DR   MassIVE; Q4VC05; -.
DR   MaxQB; Q4VC05; -.
DR   PeptideAtlas; Q4VC05; -.
DR   PRIDE; Q4VC05; -.
DR   ProteomicsDB; 62295; -. [Q4VC05-1]
DR   ProteomicsDB; 62296; -. [Q4VC05-2]
DR   Antibodypedia; 31614; 196 antibodies from 33 providers.
DR   DNASU; 605; -.
DR   Ensembl; ENST00000261822.5; ENSP00000261822.5; ENSG00000110987.9. [Q4VC05-1]
DR   Ensembl; ENST00000538010.5; ENSP00000445868.1; ENSG00000110987.9. [Q4VC05-2]
DR   Ensembl; ENST00000635191.1; ENSP00000489010.1; ENSG00000282873.3. [Q4VC05-2]
DR   Ensembl; ENST00000635403.3; ENSP00000489305.1; ENSG00000282873.3. [Q4VC05-1]
DR   GeneID; 605; -.
DR   KEGG; hsa:605; -.
DR   MANE-Select; ENST00000261822.5; ENSP00000261822.5; NM_001024808.3; NP_001019979.1.
DR   UCSC; uc001ubo.4; human. [Q4VC05-1]
DR   CTD; 605; -.
DR   DisGeNET; 605; -.
DR   GeneCards; BCL7A; -.
DR   HGNC; HGNC:1004; BCL7A.
DR   HPA; ENSG00000110987; Low tissue specificity.
DR   MIM; 601406; gene.
DR   neXtProt; NX_Q4VC05; -.
DR   OpenTargets; ENSG00000110987; -.
DR   PharmGKB; PA25314; -.
DR   VEuPathDB; HostDB:ENSG00000110987; -.
DR   eggNOG; KOG4095; Eukaryota.
DR   GeneTree; ENSGT00390000002172; -.
DR   HOGENOM; CLU_110835_0_0_1; -.
DR   InParanoid; Q4VC05; -.
DR   OMA; CNDNVAV; -.
DR   OrthoDB; 1517597at2759; -.
DR   PhylomeDB; Q4VC05; -.
DR   TreeFam; TF317441; -.
DR   PathwayCommons; Q4VC05; -.
DR   SignaLink; Q4VC05; -.
DR   BioGRID-ORCS; 605; 13 hits in 1079 CRISPR screens.
DR   ChiTaRS; BCL7A; human.
DR   GenomeRNAi; 605; -.
DR   Pharos; Q4VC05; Tbio.
DR   PRO; PR:Q4VC05; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q4VC05; protein.
DR   Bgee; ENSG00000110987; Expressed in cortical plate and 107 other tissues.
DR   Genevisible; Q4VC05; HS.
DR   GO; GO:0000785; C:chromatin; IC:ComplexPortal.
DR   GO; GO:0140288; C:GBAF complex; IC:ComplexPortal.
DR   GO; GO:0016514; C:SWI/SNF complex; IDA:UniProtKB.
DR   GO; GO:0006338; P:chromatin remodeling; IC:ComplexPortal.
DR   GO; GO:0045596; P:negative regulation of cell differentiation; IC:ComplexPortal.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; NAS:UniProtKB.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IC:ComplexPortal.
DR   GO; GO:2000781; P:positive regulation of double-strand break repair; IC:ComplexPortal.
DR   GO; GO:1902459; P:positive regulation of stem cell population maintenance; IC:ComplexPortal.
DR   GO; GO:0070316; P:regulation of G0 to G1 transition; IC:ComplexPortal.
DR   GO; GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IC:ComplexPortal.
DR   GO; GO:0030071; P:regulation of mitotic metaphase/anaphase transition; IC:ComplexPortal.
DR   GO; GO:2000819; P:regulation of nucleotide-excision repair; IC:ComplexPortal.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IC:ComplexPortal.
DR   InterPro; IPR006804; BCL7.
DR   PANTHER; PTHR12767; PTHR12767; 1.
DR   Pfam; PF04714; BCL_N; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Chromosomal rearrangement; Isopeptide bond;
KW   Phosphoprotein; Reference proteome; Ubl conjugation.
FT   CHAIN           1..210
FT                   /note="B-cell CLL/lymphoma 7 protein family member A"
FT                   /id="PRO_0000239823"
FT   REGION          48..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..74
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..121
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..148
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..183
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         203
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:17525332"
FT   MOD_RES         207
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:17525332"
FT   CROSSLNK        199
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0007744|PubMed:25218447"
FT   VAR_SEQ         187
FT                   /note="Q -> QVPRSRSQRGSQIGREPIGLSG (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:8605326"
FT                   /id="VSP_019271"
FT   VARIANT         120
FT                   /note="N -> T (in dbSNP:rs34821485)"
FT                   /id="VAR_033539"
SQ   SEQUENCE   210 AA;  22810 MW;  4AB4AC3B309ADDB8 CRC64;
     MSGRSVRAET RSRAKDDIKR VMAAIEKVRK WEKKWVTVGD TSLRIYKWVP VTEPKVDDKN
     KNKKKGKDEK CGSEVTTPEN SSSPGMMDMH DDNSNQSSIA DASPIKQENS SNSSPAPEPN
     SAVPSDGTEA KVDEAQADGK EHPGAEDASD EQNSQSSMEH SMNSSEKVDR QPSGDSGLAA
     ETSAISQDLE GVPPSKKMKL EASQQNSEEM
 
 
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