ID   BCL7_CAEEL              Reviewed;         146 AA.
AC   Q09242;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=BCL7-like protein {ECO:0000305};
GN   Name=bcl-7 {ECO:0000312|WormBase:C28H8.1};
GN   ORFNames=C28H8.1 {ECO:0000312|WormBase:C28H8.1};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP   AND DISRUPTION PHENOTYPE.
RX   PubMed=25569233; DOI=10.1371/journal.pgen.1004921;
RA   Uehara T., Kage-Nakadai E., Yoshina S., Imae R., Mitani S.;
RT   "The tumor suppressor BCL7B functions in the Wnt signaling pathway.";
RL   PLoS Genet. 11:E1004921-E1004921(2015).
CC   -!- FUNCTION: Required for the terminal differentiation of seam cells, and
CC       the differentiation of distal tip cells important for normal somatic
CC       gonad and germ cell development. Plays a role in the Wnt signaling
CC       pathway, regulating the expression of beta-catenin homologs wrm-1, bar-
CC       1 and sys-1, and the localization of wrm-1 and the wnt signaling
CC       pathway component pop-1 during asymmetric cell division of seam cells
CC       and the Z-cell lineage of the somatic gonad, respectively. May have a
CC       pro-apoptotic role, possibly linked to the negative regulation of
CC       expression of anti-apoptotic factor ced-9.
CC       {ECO:0000269|PubMed:25569233}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25569233}.
CC   -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:25569233}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the hypodermis from embryogenesis to
CC       adulthood. {ECO:0000269|PubMed:25569233}.
CC   -!- DISRUPTION PHENOTYPE: Animals are sterile producing no oocytes, display
CC       a protruding vulva phenotype past the young adult stage of development,
CC       and have disrupted or no alae formation. Fewer seam cells in larval
CC       stages post the L1 larval stage of development and impaired seam cell
CC       differentiation with large and irregularly shaped nuclei in seam cell-
CC       derived hyp7 cells. Defective gonadal growth and proliferation whereby
CC       gonads are thin and shortened probably due to decreased mitosis, and
CC       abnormal germ cell nuclei which are irregularly shaped and enlargened.
CC       Mis-localization of the beta-catenin homolog wrm-1 in the daughter
CC       cells of seam cells following cell division with expression equal to or
CC       stronger in the anterior daughter cells as opposed to the posterior
CC       daughter cells in 50% of mutants. Aberrant asymmetric localization of
CC       the wnt signaling component pop-1 in the nuclei of Z1 and Z4 somatic
CC       gonadal precursor cells. Increased expression of anti-apoptotic factor
CC       ced-9. RNAi-mediated knockdown results in egg-laying defective and
CC       burst vulva phenotypes. {ECO:0000269|PubMed:25569233}.
CC   -!- SIMILARITY: Belongs to the BCL7 family. {ECO:0000305}.
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DR   EMBL; FO080703; CCD65961.1; -; Genomic_DNA.
DR   PIR; E88470; E88470.
DR   RefSeq; NP_498287.1; NM_065886.3.
DR   AlphaFoldDB; Q09242; -.
DR   IntAct; Q09242; 1.
DR   STRING; 6239.C28H8.1; -.
DR   EPD; Q09242; -.
DR   PaxDb; Q09242; -.
DR   PeptideAtlas; Q09242; -.
DR   EnsemblMetazoa; C28H8.1.1; C28H8.1.1; WBGene00016192.
DR   GeneID; 175838; -.
DR   KEGG; cel:CELE_C28H8.1; -.
DR   UCSC; C28H8.1; c. elegans.
DR   CTD; 175838; -.
DR   WormBase; C28H8.1; CE01820; WBGene00016192; bcl-7.
DR   eggNOG; KOG4095; Eukaryota.
DR   GeneTree; ENSGT00390000002172; -.
DR   HOGENOM; CLU_110835_2_1_1; -.
DR   InParanoid; Q09242; -.
DR   OMA; WEKKWIV; -.
DR   OrthoDB; 1517597at2759; -.
DR   PhylomeDB; Q09242; -.
DR   PRO; PR:Q09242; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00016192; Expressed in embryo and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR006804; BCL7.
DR   PANTHER; PTHR12767; PTHR12767; 1.
DR   Pfam; PF04714; BCL_N; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Differentiation; Nucleus; Reference proteome;
KW   Wnt signaling pathway.
FT   CHAIN           1..146
FT                   /note="BCL7-like protein"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000065197"
FT   REGION          59..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..146
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   146 AA;  16668 MW;  54B54148DE88A5E3 CRC64;
     MYSANRSHRA ETRNRSKDEL RKVINSLEKV RRWEKKLVLI KDTNIRIYKW VPVSAQNIMA
     PPKIKEVKEV DEESNQVPSA ENSQDSTSVT QPPPQFDINE DSNFSTGDHF DSDSNQTFEP
     QNYQGGATGS TDFSSMRDAE MTSKQP