RT05_BOVIN
ID RT05_BOVIN Reviewed; 430 AA.
AC Q2KID9; P82674;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=28S ribosomal protein S5, mitochondrial;
DE Short=MRP-S5;
DE Short=S5mt;
GN Name=MRPS5;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PROTEIN SEQUENCE OF 93-100 AND 396-405, SUBUNIT, AND SUBCELLULAR LOCATION.
RC TISSUE=Liver;
RX PubMed=11344316; DOI=10.1110/ps.35301;
RA Koc E.C., Burkhart W., Blackburn K., Koc H., Moseley A., Spremulli L.L.;
RT "Identification of four proteins from the small subunit of the mammalian
RT mitochondrial ribosome using a proteomics approach.";
RL Protein Sci. 10:471-481(2001).
RN [3]
RP STRUCTURE BY ELECTRON MICROSCOPY (7.00 ANGSTROMS), SUBCELLULAR LOCATION,
RP AND SUBUNIT.
RX PubMed=24799711; DOI=10.1073/pnas.1401657111;
RA Kaushal P.S., Sharma M.R., Booth T.M., Haque E.M., Tung C.S.,
RA Sanbonmatsu K.Y., Spremulli L.L., Agrawal R.K.;
RT "Cryo-EM structure of the small subunit of the mammalian mitochondrial
RT ribosome.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:7284-7289(2014).
CC -!- SUBUNIT: Component of the mitochondrial ribosome small subunit (28S)
CC which comprises a 12S rRNA and about 30 distinct proteins.
CC {ECO:0000269|PubMed:11344316, ECO:0000269|PubMed:24799711}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11344316,
CC ECO:0000269|PubMed:24799711}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS5 family.
CC {ECO:0000305}.
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DR EMBL; BC112674; AAI12675.1; -; mRNA.
DR RefSeq; NP_001039588.1; NM_001046123.2.
DR PDB; 3JD5; EM; 7.00 A; E=1-430.
DR PDB; 6NEQ; EM; 3.32 A; E=1-430.
DR PDB; 6NF8; EM; 3.48 A; E=1-430.
DR PDBsum; 3JD5; -.
DR PDBsum; 6NEQ; -.
DR PDBsum; 6NF8; -.
DR AlphaFoldDB; Q2KID9; -.
DR SMR; Q2KID9; -.
DR CORUM; Q2KID9; -.
DR IntAct; Q2KID9; 1.
DR STRING; 9913.ENSBTAP00000010843; -.
DR PaxDb; Q2KID9; -.
DR PRIDE; Q2KID9; -.
DR Ensembl; ENSBTAT00000070203; ENSBTAP00000069289; ENSBTAG00000008241.
DR GeneID; 512469; -.
DR KEGG; bta:512469; -.
DR CTD; 64969; -.
DR VEuPathDB; HostDB:ENSBTAG00000008241; -.
DR VGNC; VGNC:31675; MRPS5.
DR eggNOG; KOG2646; Eukaryota.
DR GeneTree; ENSGT00390000001878; -.
DR HOGENOM; CLU_050434_0_0_1; -.
DR InParanoid; Q2KID9; -.
DR OMA; NTVNFFM; -.
DR OrthoDB; 1262134at2759; -.
DR TreeFam; TF313823; -.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000008241; Expressed in corpus luteum and 105 other tissues.
DR ExpressionAtlas; Q2KID9; baseline and differential.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; HDA:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; HDA:UniProtKB.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR Gene3D; 3.30.230.10; -; 1.
DR InterPro; IPR000851; Ribosomal_S5.
DR InterPro; IPR005324; Ribosomal_S5_C.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR InterPro; IPR013810; Ribosomal_S5_N.
DR InterPro; IPR018192; Ribosomal_S5_N_CS.
DR PANTHER; PTHR13718; PTHR13718; 1.
DR Pfam; PF00333; Ribosomal_S5; 1.
DR Pfam; PF03719; Ribosomal_S5_C; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR PROSITE; PS00585; RIBOSOMAL_S5; 1.
DR PROSITE; PS50881; S5_DSRBD; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Mitochondrion; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..430
FT /note="28S ribosomal protein S5, mitochondrial"
FT /id="PRO_0000240302"
FT DOMAIN 218..282
FT /note="S5 DRBM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00268"
FT REGION 108..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 405
FT /note="K -> Q (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT TURN 127..129
FT /evidence="ECO:0007829|PDB:6NEQ"
FT STRAND 142..146
FT /evidence="ECO:0007829|PDB:6NEQ"
FT STRAND 150..153
FT /evidence="ECO:0007829|PDB:6NEQ"
FT STRAND 162..164
FT /evidence="ECO:0007829|PDB:6NF8"
FT HELIX 165..184
FT /evidence="ECO:0007829|PDB:6NEQ"
FT STRAND 192..194
FT /evidence="ECO:0007829|PDB:6NEQ"
FT STRAND 210..212
FT /evidence="ECO:0007829|PDB:6NF8"
FT STRAND 221..228
FT /evidence="ECO:0007829|PDB:6NEQ"
FT STRAND 233..235
FT /evidence="ECO:0007829|PDB:6NEQ"
FT STRAND 240..246
FT /evidence="ECO:0007829|PDB:6NEQ"
FT STRAND 250..254
FT /evidence="ECO:0007829|PDB:6NEQ"
FT STRAND 256..263
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 264..275
FT /evidence="ECO:0007829|PDB:6NEQ"
FT TURN 286..288
FT /evidence="ECO:0007829|PDB:6NEQ"
FT STRAND 294..298
FT /evidence="ECO:0007829|PDB:6NF8"
FT STRAND 304..306
FT /evidence="ECO:0007829|PDB:6NEQ"
FT STRAND 310..312
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 318..327
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 342..354
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 359..366
FT /evidence="ECO:0007829|PDB:6NEQ"
FT STRAND 368..373
FT /evidence="ECO:0007829|PDB:6NEQ"
FT STRAND 375..377
FT /evidence="ECO:0007829|PDB:6NEQ"
FT STRAND 382..385
FT /evidence="ECO:0007829|PDB:6NEQ"
FT HELIX 409..413
FT /evidence="ECO:0007829|PDB:6NEQ"
FT TURN 414..416
FT /evidence="ECO:0007829|PDB:6NEQ"
SQ SEQUENCE 430 AA; 47872 MW; 5E379D33F4DA493F CRC64;
MAAAVRAAGF LPALCGASAG RLWSRQLYLN TFPTASIWAL KAVPSNGPSS SAGARGRCRS
THLGPALQTQ CCTPAPGNVT AQQYRSYSFF TKLTADELWK GALAETGAGA RKGRGKRTKR
KRRKDLNRGQ IIGEGRRGFL WPGLNAPLMK SGAIQTITQR SKEEQEKVEA DMVQQREEWD
RKRKMKVKRE RGWSGNSWGG ISLGPPDPGP NGETYDDFDT RILEVRNVFN MTAKEGRKRS
VRVLVAVGNG RGAAGFAIGK ATERADAFRK AKNRAVHYLH YIERYEDHTI YHDISLTFKR
THIKMKKQPR GYGLRCHRAI TTICRLIGIK DMYAKVSGSV NMLSLTRGLF QGLSRQETHQ
QLADKKSLHV VEFREECGPL PIVVASPQGA LRKDPEPEDE VPDIKLDWDD VKAVQGMKRS
VWSGLKRAAT
