BCL9L_DANRE
ID BCL9L_DANRE Reviewed; 1530 AA.
AC Q67FY3;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=B-cell CLL/lymphoma 9-like protein;
DE Short=B-cell lymphoma 9-like protein;
DE Short=BCL9-like protein;
DE AltName: Full=Protein BCL9-2;
GN Name=bcl9l;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=15371335; DOI=10.1101/gad.317604;
RA Brembeck F.H., Schwarz-Romond T., Bakkers J., Wilhelm S., Hammerschmidt M.,
RA Birchmeier W.;
RT "Essential role of BCL9-2 in the switch between beta-catenin's adhesive and
RT transcriptional functions.";
RL Genes Dev. 18:2225-2230(2004).
CC -!- FUNCTION: Transcriptional regulator that may act as an activator (By
CC similarity). Plays a role for mesoderm patterning in early
CC embryogenesis. {ECO:0000250, ECO:0000269|PubMed:15371335}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Highly expressed during gastrulation.
CC {ECO:0000269|PubMed:15371335}.
CC -!- DISRUPTION PHENOTYPE: Severe defects of trunk and tail development.
CC {ECO:0000269|PubMed:15371335}.
CC -!- SIMILARITY: Belongs to the BCL9 family. {ECO:0000305}.
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DR EMBL; AY296057; AAQ62695.1; -; mRNA.
DR RefSeq; NP_001005575.1; NM_001005575.1.
DR AlphaFoldDB; Q67FY3; -.
DR SMR; Q67FY3; -.
DR STRING; 7955.ENSDARP00000123831; -.
DR PaxDb; Q67FY3; -.
DR GeneID; 449532; -.
DR KEGG; dre:449532; -.
DR CTD; 283149; -.
DR ZFIN; ZDB-GENE-040927-29; bcl9l.
DR eggNOG; ENOG502QR2B; Eukaryota.
DR InParanoid; Q67FY3; -.
DR Reactome; R-DRE-201722; Formation of the beta-catenin:TCF transactivating complex.
DR PRO; PR:Q67FY3; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:1990907; C:beta-catenin-TCF complex; IBA:GO_Central.
DR GO; GO:0008013; F:beta-catenin binding; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:InterPro.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0048368; P:lateral mesoderm development; IMP:ZFIN.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0036342; P:post-anal tail morphogenesis; IMP:ZFIN.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR015668; Bcl-9/Bcl-9l.
DR InterPro; IPR024670; BCL9_beta-catenin-bd_dom.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR15185; PTHR15185; 1.
DR Pfam; PF11502; BCL9; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..1530
FT /note="B-cell CLL/lymphoma 9-like protein"
FT /id="PRO_0000314081"
FT REGION 1..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..1076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1250..1279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1310..1331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..889
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 918..949
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..983
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1063
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1530 AA; 159872 MW; C29FEC9433ED28C0 CRC64;
MHSENKLSNH GKQVTSGAQS QLPNVNQAQQ QAPAGIQGSK GSVSGNHGVK ANQISPGNPG
LKSLNQTGGG GGMMKTKAKR ERSVSIDTGD QRESLTPVLE PDAKVEGVMR SKRRCVLERK
QPYSGDEWCS GAETEEEDEK PLSATHREHV MCPSQGHSGS STTGHVSDPG GPGLGSGHGP
GIRTDLHSRP PQQVVYVFTT SLANSAAEAV MHGHTDSILL YHQQNVPRTK LDQSTGVGKV
SNLAEHISSS HSPPIGTPKS QSGTPRPASV GGVGHLPGTS TPSSTGHPDS EPAQTHRGGG
TSSNNGRSAV HTLGLGNSGP QSVGVSGTEG VDRPGAIPHH GAGVSPSTSP SVLSALRQSE
LGQRVGPGNT DGLSKEQLEH RERSLQTLRD IERLLLRSGT GVAQEDPRGP NGNPNGTNVN
NNNSNDGGRG LEDGEIGGGI PGNCHINNAG MPGMPPVGGM KKYEEPLQSI ISQTQNLGGP
GLDDSLMGPH HGMPPHSHHL SSPSGLDMGP LLGPEGVTPE QLAWRKLQEE YYQEKRRQHD
MNPHQHPQHF RIMPEMGMPG GPPMLMRGPP PPYHSKPGDQ QWGPGPMVGG GMGGNARMMD
MNQEGPRGPR FLGQMRGPSG GGGYPESPGG VLGVEGLGPQ RPPRPGMGWL EEIPPNMGGG
GPFHGCCPPG GPGGPPQHFQ GDLDRPMTRE EIYRRIHRLD LQQMSRQQQQ AGLGGPRMMD
NPGGPGFPNP GMAGGPPSRG DPMDFPVSRT IMGSPIGGVG GDGGPTMRDI VDSPLGGNLN
MNMGMNINQQ QQLLAQKLRG GPGVLGEMLN AEDISRIRAS QNGRGGANKA MIPGPEGPLQ
FPNQSSFPGG QVDGPYLQQP GPDMYGPDQP GPPHLSSTSR LSHIPMNTGS RVTDLGARHP
PDLPISVNPM GSPAIPPSHQ LKSPSLSQEP SPLMPSPSAA GLKSPSQLPQ SGPTHPPLPA
ASGAGTPSST SIKSPQVMGP SLGLRSPSGS PGHLKSPSMP VASPGWTASP KAAMPSPGGP
PSVKVTGNGG SSSTDTGMSL PPRSSNSTPI SQPSNSINPS MPFTSSPDAP PSQNPLSLIM
SQMSKYAMPS STPLYHDAIK TIATSDDEML PDRPLQPGTN MSVGGMGNHQ SAQMLLSSQG
AMGPHSGPQS PMGMVLQGGP PLSHDHPGPM LPSPNPMGIP GMPSEIMGGG GGPPDGIGPC
NVSPMHTQNQ MGGFPRIQGP LHSPIGGMGQ QFPPRPDDVL PPQQMHLLSK GMSHQRPPHQ
PDSFPPMPMG DGPDLSEVIR PTHRGIPEFD LSRIIPADKP SSTLQYFPKS ETMSQPQQNP
HQGQPPPQVS SAQLLKQLSS SGPPHSNIPS SNPHIANLQN MMAEQQLPLH PSHCGMRPGM
GMPQIGSRGM GSGGGMGPMC HPGHMMGRTG MSPQQQLQQQ HHHQQQQAMM ANNLLQHPSH
PPRGMLSPQQ HPHNLIAQQN LMMMQAKQRG MALPGEHFGQ QGALMSPQGP MMGPPHSQTG
MMGPQSLRQR SMSLDSPLGY GPGSMANMPF
