RT06_HUMAN
ID RT06_HUMAN Reviewed; 125 AA.
AC P82932; B2R573; Q96Q64; Q9BSK8; Q9BW89;
DT 04-MAY-2001, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 186.
DE RecName: Full=28S ribosomal protein S6, mitochondrial;
DE Short=MRP-S6;
DE Short=S6mt;
DE AltName: Full=Mitochondrial small ribosomal subunit protein bS6m {ECO:0000303|PubMed:25838379};
GN Name=MRPS6; Synonyms=C21orf101, RPMS6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11402041; DOI=10.1074/jbc.m103236200;
RA Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A.,
RA Watanabe K.;
RT "Proteomic analysis of the mammalian mitochondrial ribosome. Identification
RT of protein components in the 28S small subunit.";
RL J. Biol. Chem. 276:33181-33195(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12036297; DOI=10.1006/geno.2002.6781;
RA Reymond A., Camargo A.A., Deutsch S., Stevenson B.J., Parmigiani R.B.,
RA Ucla C., Bettoni F., Rossier C., Lyle R., Guipponi M., de Souza S.,
RA Iseli C., Jongeneel C.V., Bucher P., Simpson A.J.G., Antonarakis S.E.;
RT "Nineteen additional unpredicted transcripts from human chromosome 21.";
RL Genomics 79:824-832(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=B-cell, Brain, Kidney, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE OF 28-62.
RX PubMed=11543634; DOI=10.1006/geno.2001.6622;
RA Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S.,
RA Watanabe K., Tanaka T.;
RT "The human mitochondrial ribosomal protein genes: mapping of 54 genes to
RT the chromosomes and implications for human disorders.";
RL Genomics 77:65-70(2001).
RN [8]
RP IDENTIFICATION.
RX PubMed=11279123; DOI=10.1074/jbc.m100727200;
RA Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.;
RT "The small subunit of the mammalian mitochondrial ribosome: identification
RT of the full complement of ribosomal proteins present.";
RL J. Biol. Chem. 276:19363-19374(2001).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [11] {ECO:0007744|PDB:3J9M}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS), SUBCELLULAR LOCATION,
RP AND SUBUNIT.
RX PubMed=25838379; DOI=10.1126/science.aaa1193;
RA Amunts A., Brown A., Toots J., Scheres S.H., Ramakrishnan V.;
RT "Ribosome. The structure of the human mitochondrial ribosome.";
RL Science 348:95-98(2015).
CC -!- SUBUNIT: Component of the mitochondrial small ribosomal subunit (mt-
CC SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small
CC (28S) and a large (39S) subunit. The 28S small subunit contains a 12S
CC ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large
CC subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial
CC valine transfer RNA (mt-tRNA(Val)), which plays an integral structural
CC role, and 52 different proteins. {ECO:0000269|PubMed:25838379}.
CC -!- INTERACTION:
CC P82932; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-716172, EBI-739832;
CC P82932; Q13064: MKRN3; NbExp=3; IntAct=EBI-716172, EBI-2340269;
CC P82932; P51692: STAT5B; NbExp=3; IntAct=EBI-716172, EBI-1186119;
CC P82932; P03410: tax; Xeno; NbExp=3; IntAct=EBI-716172, EBI-9676218;
CC P82932; P14079: tax; Xeno; NbExp=3; IntAct=EBI-716172, EBI-9675698;
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
CC -!- SIMILARITY: Belongs to the bacterial ribosomal protein bS6 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB40995.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB049942; BAB40995.1; ALT_INIT; mRNA.
DR EMBL; AY061855; AAL35739.1; -; mRNA.
DR EMBL; AK312084; BAG35020.1; -; mRNA.
DR EMBL; AP001719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471079; EAX09798.1; -; Genomic_DNA.
DR EMBL; BC000547; AAH00547.2; -; mRNA.
DR EMBL; BC004976; AAH04976.2; -; mRNA.
DR EMBL; BC010076; AAH10076.1; -; mRNA.
DR EMBL; BC051302; AAH51302.1; -; mRNA.
DR EMBL; AB051347; BAB54937.1; -; Genomic_DNA.
DR CCDS; CCDS33548.1; -.
DR RefSeq; NP_115865.1; NM_032476.3.
DR PDB; 3J9M; EM; 3.50 A; AE=1-125.
DR PDB; 6NU2; EM; 3.90 A; AE=2-123.
DR PDB; 6NU3; EM; 4.40 A; AE=1-125.
DR PDB; 6RW4; EM; 2.97 A; E=1-125.
DR PDB; 6RW5; EM; 3.14 A; E=1-125.
DR PDB; 6VLZ; EM; 2.97 A; AE=1-125.
DR PDB; 6VMI; EM; 2.96 A; AE=1-125.
DR PDB; 6ZM5; EM; 2.89 A; AE=1-125.
DR PDB; 6ZM6; EM; 2.59 A; AE=1-125.
DR PDB; 6ZS9; EM; 4.00 A; AE=1-125.
DR PDB; 6ZSA; EM; 4.00 A; AE=1-125.
DR PDB; 6ZSB; EM; 4.50 A; AE=1-125.
DR PDB; 6ZSC; EM; 3.50 A; AE=1-125.
DR PDB; 6ZSD; EM; 3.70 A; AE=1-125.
DR PDB; 6ZSE; EM; 5.00 A; AE=1-125.
DR PDB; 6ZSG; EM; 4.00 A; AE=1-125.
DR PDB; 7A5F; EM; 4.40 A; E6=1-125.
DR PDB; 7A5G; EM; 4.33 A; E6=1-125.
DR PDB; 7A5I; EM; 3.70 A; E6=1-125.
DR PDB; 7A5K; EM; 3.70 A; E6=1-125.
DR PDB; 7L08; EM; 3.49 A; AE=1-125.
DR PDB; 7OG4; EM; 3.80 A; AE=1-125.
DR PDBsum; 3J9M; -.
DR PDBsum; 6NU2; -.
DR PDBsum; 6NU3; -.
DR PDBsum; 6RW4; -.
DR PDBsum; 6RW5; -.
DR PDBsum; 6VLZ; -.
DR PDBsum; 6VMI; -.
DR PDBsum; 6ZM5; -.
DR PDBsum; 6ZM6; -.
DR PDBsum; 6ZS9; -.
DR PDBsum; 6ZSA; -.
DR PDBsum; 6ZSB; -.
DR PDBsum; 6ZSC; -.
DR PDBsum; 6ZSD; -.
DR PDBsum; 6ZSE; -.
DR PDBsum; 6ZSG; -.
DR PDBsum; 7A5F; -.
DR PDBsum; 7A5G; -.
DR PDBsum; 7A5I; -.
DR PDBsum; 7A5K; -.
DR PDBsum; 7L08; -.
DR PDBsum; 7OG4; -.
DR AlphaFoldDB; P82932; -.
DR SMR; P82932; -.
DR BioGRID; 122361; 162.
DR ComplexPortal; CPX-5225; 28S mitochondrial small ribosomal subunit.
DR CORUM; P82932; -.
DR IntAct; P82932; 49.
DR MINT; P82932; -.
DR STRING; 9606.ENSP00000382250; -.
DR GlyGen; P82932; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; P82932; -.
DR MetOSite; P82932; -.
DR PhosphoSitePlus; P82932; -.
DR BioMuta; MRPS6; -.
DR DMDM; 13959558; -.
DR EPD; P82932; -.
DR jPOST; P82932; -.
DR MassIVE; P82932; -.
DR MaxQB; P82932; -.
DR PaxDb; P82932; -.
DR PeptideAtlas; P82932; -.
DR PRIDE; P82932; -.
DR ProteomicsDB; 57723; -.
DR TopDownProteomics; P82932; -.
DR Antibodypedia; 35213; 71 antibodies from 17 providers.
DR DNASU; 64968; -.
DR Ensembl; ENST00000399312.3; ENSP00000382250.2; ENSG00000243927.6.
DR GeneID; 64968; -.
DR KEGG; hsa:64968; -.
DR MANE-Select; ENST00000399312.3; ENSP00000382250.2; NM_032476.4; NP_115865.1.
DR UCSC; uc002ytp.2; human.
DR CTD; 64968; -.
DR DisGeNET; 64968; -.
DR GeneCards; MRPS6; -.
DR HGNC; HGNC:14051; MRPS6.
DR HPA; ENSG00000243927; Low tissue specificity.
DR MIM; 611973; gene.
DR neXtProt; NX_P82932; -.
DR OpenTargets; ENSG00000243927; -.
DR PharmGKB; PA31025; -.
DR VEuPathDB; HostDB:ENSG00000243927; -.
DR eggNOG; KOG4708; Eukaryota.
DR GeneTree; ENSGT00390000014606; -.
DR HOGENOM; CLU_126331_4_2_1; -.
DR InParanoid; P82932; -.
DR OMA; MTKHNQR; -.
DR PhylomeDB; P82932; -.
DR TreeFam; TF314045; -.
DR PathwayCommons; P82932; -.
DR Reactome; R-HSA-5368286; Mitochondrial translation initiation.
DR Reactome; R-HSA-5389840; Mitochondrial translation elongation.
DR Reactome; R-HSA-5419276; Mitochondrial translation termination.
DR SignaLink; P82932; -.
DR SIGNOR; P82932; -.
DR BioGRID-ORCS; 64968; 430 hits in 1078 CRISPR screens.
DR ChiTaRS; MRPS6; human.
DR GeneWiki; MRPS6; -.
DR GenomeRNAi; 64968; -.
DR Pharos; P82932; Tbio.
DR PRO; PR:P82932; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; P82932; protein.
DR Bgee; ENSG00000243927; Expressed in renal medulla and 183 other tissues.
DR Genevisible; P82932; HS.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0015935; C:small ribosomal subunit; NAS:UniProtKB.
DR GO; GO:0070181; F:small ribosomal subunit rRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; ISS:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; ISS:UniProtKB.
DR GO; GO:0006412; P:translation; NAS:UniProtKB.
DR Gene3D; 3.30.70.60; -; 1.
DR InterPro; IPR000529; Ribosomal_S6.
DR InterPro; IPR035980; Ribosomal_S6_sf.
DR InterPro; IPR014717; Transl_elong_EF1B/ribosomal_S6.
DR PANTHER; PTHR21011; PTHR21011; 1.
DR Pfam; PF01250; Ribosomal_S6; 1.
DR SUPFAM; SSF54995; SSF54995; 1.
DR TIGRFAMs; TIGR00166; S6; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Mitochondrion; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT CHAIN 1..125
FT /note="28S ribosomal protein S6, mitochondrial"
FT /id="PRO_0000176892"
SQ SEQUENCE 125 AA; 14227 MW; 65995BB83B76F127 CRC64;
MPRYELALIL KAMQRPETAA TLKRTIEALM DRGAIVRDLE NLGERALPYR ISAHSQQHNR
GGYFLVDFYA PTAAVESMVE HLSRDIDVIR GNIVKHPLTQ ELKECEGIVP VPLAEKLYST
KKRKK
