RT106_ASHGO
ID RT106_ASHGO Reviewed; 421 AA.
AC Q75E35;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Histone chaperone RTT106;
GN Name=RTT106; OrderedLocusNames=ABL165C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Histones H3 and H4 chaperone involved in the nucleosome
CC formation and heterochromatin silencing. Required for the deposition of
CC H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role
CC in the transcriptional regulation of the cell-cycle dependent histone
CC genes by creating a repressive structure at the core histone gene
CC promoter (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with histones H3 and H4. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RTT106 family. {ECO:0000305}.
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DR EMBL; AE016815; AAS50606.1; -; Genomic_DNA.
DR RefSeq; NP_982782.1; NM_208135.1.
DR AlphaFoldDB; Q75E35; -.
DR SMR; Q75E35; -.
DR STRING; 33169.AAS50606; -.
DR EnsemblFungi; AAS50606; AAS50606; AGOS_ABL165C.
DR GeneID; 4618862; -.
DR KEGG; ago:AGOS_ABL165C; -.
DR eggNOG; ENOG502R9PE; Eukaryota.
DR HOGENOM; CLU_040939_1_0_1; -.
DR InParanoid; Q75E35; -.
DR OMA; TRLTFNV; -.
DR Proteomes; UP000000591; Chromosome II.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:EnsemblFungi.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR GO; GO:0006335; P:DNA replication-dependent chromatin assembly; IEA:EnsemblFungi.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IEA:EnsemblFungi.
DR GO; GO:0031507; P:heterochromatin assembly; IEA:EnsemblFungi.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR CDD; cd11604; RTT106_N; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR013719; DUF1747.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR040993; Rtt106_N.
DR InterPro; IPR040770; Rtt106_PH.
DR Pfam; PF18469; PH_18; 1.
DR Pfam; PF08512; Rtt106; 1.
DR SMART; SM01287; Rtt106; 1.
PE 3: Inferred from homology;
KW Chaperone; Chromosome; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..421
FT /note="Histone chaperone RTT106"
FT /id="PRO_0000320481"
FT REGION 286..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..368
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 421 AA; 47178 MW; 1F33BF5281CAE549 CRC64;
MPEFLERLPH AVKQKVLQIS NNDAKILGVF EQVFQCGQEN QDARRKAVKT GVSERLEDSE
LIFELRDVSF LSPIRKKLNL AITIGSDGKP ALLFNKDRVP EMAIPNLQES VKFAAFLPFP
EKKNLLYLFI VYRTASDEAP DPVLLTMNKE GVLKQFKDKG LIPVDSSNFG ECVDYMRKQA
ILTGFRIGDP FSNSQGPPAF HVECHRGTKE GTLYFLPDHI IFGFKKPILV FESNEIESIT
YSSITRLTFN VTLITKNQEK YEFSMIDQSE FANIDEYVKR NQVKDKSMSD ELKAKPMVKA
HQVGEQSALK EAQQQLRENR PTGGVPIDSD DEEADGNFES ESELSDGSGS DSEADSDEDA
DDTDDSDGTN DTHDVLQHEE IQIAAADAED EVLPDFDQAE AGIDIVIEED DEEEGSGVEY
D