ID   BCL9_PIG                Reviewed;         130 AA.
AC   Q95KQ6;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=B-cell CLL/lymphoma 9 protein;
DE            Short=B-cell lymphoma 9 protein;
DE            Short=Bcl-9;
DE   Flags: Fragment;
GN   Name=BCL9;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12047235; DOI=10.1046/j.1365-2052.2002.0831e.x;
RA   Knoll A., Dvorak J., Rohrer G.A., Cepica S.;
RT   "Linkage and cytogenetic mapping of the BCL9 gene to porcine chromosome
RT   4.";
RL   Anim. Genet. 33:162-163(2002).
CC   -!- FUNCTION: Involved in signal transduction through the Wnt pathway.
CC       Promotes beta-catenin's transcriptional activity (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds to beta-catenin (CTNNB1), PYGO1 and PYGO2; the
CC       interaction with PYGO1 increases PYGO1 affinity to histone H3
CC       methylated at 'Lys 4'. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BCL9 family. {ECO:0000305}.
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DR   EMBL; AJ416471; CAC94924.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q95KQ6; -.
DR   STRING; 9823.ENSSSCP00000007142; -.
DR   PaxDb; Q95KQ6; -.
DR   eggNOG; ENOG502QREN; Eukaryota.
DR   HOGENOM; CLU_004930_1_0_1; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   Genevisible; Q95KQ6; SS.
DR   GO; GO:1990907; C:beta-catenin-TCF complex; IBA:GO_Central.
DR   GO; GO:0008013; F:beta-catenin binding; IBA:GO_Central.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:InterPro.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR015668; Bcl-9/Bcl-9l.
DR   PANTHER; PTHR15185; PTHR15185; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Wnt signaling pathway.
FT   CHAIN           <1..>130
FT                   /note="B-cell CLL/lymphoma 9 protein"
FT                   /id="PRO_0000064887"
FT   REGION          1..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         130
SQ   SEQUENCE   130 AA;  13069 MW;  E3C8383F34404DA3 CRC64;
     PMGMTQPLSH SNQMPSPNAM GPNIPPHGVP MGPGLMSHNP IMGHGSQEPP MVPQGRMGFP
     QGFPPVQSPP QQVPFPHNGP SGGQGNFPGG MGFPGEGPLG RPSNLPQSSA DAALCKPGGP
     GGPDSFAVLG