ID   RT106_ASPOR             Reviewed;         515 AA.
AC   Q2UMB1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Histone chaperone rtt106;
GN   Name=rtt106; ORFNames=AO090003000069;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Histones H3 and H4 chaperone involved in the nucleosome
CC       formation and heterochromatin silencing. Required for the deposition of
CC       H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role
CC       in the transcriptional regulation of the cell-cycle dependent histone
CC       genes by creating a repressive structure at the core histone gene
CC       promoter (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with histones H3 and H4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RTT106 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE57304.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AP007155; BAE57304.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; Q2UMB1; -.
DR   SMR; Q2UMB1; -.
DR   STRING; 510516.Q2UMB1; -.
DR   Proteomes; UP000006564; Chromosome 2.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR013719; DUF1747.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   Pfam; PF08512; Rtt106; 1.
DR   SMART; SM01287; Rtt106; 1.
PE   3: Inferred from homology;
KW   Chaperone; Chromosome; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..515
FT                   /note="Histone chaperone rtt106"
FT                   /id="PRO_0000320485"
FT   REGION          62..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          362..439
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        391..432
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   515 AA;  56765 MW;  50ECFEB15E3D4DF5 CRC64;
     MAFAAINLSA TKKIPAIEDA FAAEPSLKKR VYDAIGTTPQ YIPLFEDIAK YTSSLLVRNA
     SAPVQPVETP TDGPAAKKRK LQNGDTAGQA QSPGDLKADA PLQFYMQDIS FALPQRKKLT
     LEITAGRGFL RARNQTSKAV EFGIHVDKIQ HVLCLPVPEK NQKQFNFCII PQYGDGINSP
     PEGETAPEAM VWTVNDGPPR AAFSGNGQQM GSNDGQTAEN VVRQMLNENL SQTKVVRPDE
     REFVSAMPEA HRKGEKAYHV KAFRGSKEGY LFFLSTGILF GFKKPLVFFA FENIDSISYT
     SVLQRTLNLN IVARPTSSDE TQELEFSMID QADFAGIDAY IKKHGLQDAS LAEARRAKRY
     NINGAKTGEE GAMDADGPVE EESELQKAQR ELDDEEDEDE EDYDPGSDDS NDGSGSSSEE
     DSDEDGDEDE EPFQGGMVCG FQPPGSAPLP YKKIHARAVW WVTYVSGGAF QCFGWLFNCI
     CRLLLCISPS AIHYALTVSP KTPRFVVTRI CILRR